RAD52
The RAD52 gene is a DNA recombinase that allows for cells with shortened telomeres to use homologous recombination to re-extend their telomeres. It is involved in repairing DNA double strand breaks by working with RAD51. In cells with a single EST2 deletion, the RAD52 gene codes for an alternate pathway of recovery. In cells with a double deletion for both EST2 and RAD52, they will reach senescence and not recover.
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