SilverSURF Environmental pollution with harmful quantities of heavy metal ions has become an urgent problem.SilverSURF makes use of the flagellar filament that represents one of the largest scaffolds in nature, and combines it with the unique potential of high-affinity metal-binding domains.
CancerSURF Lung cancer is one of the most malignant cancers with poor prognosis.CancerSURF combines the scaffold of a tetrameric Streptavidin to increase the specificity of a DARPin to detect a prominent tumor marker of lung cancer cells, called EpCAM (epithelial cell adhesion molecule). This system can find several approaches in medical treatment, for example serving as an inhaled alternative to (aerosolized) chemotherapy or as a diagnostic tool via surgery, indicating remaining tumor cells.
RiboSURF Ribosomes synthesize proteins from amino acids using mRNA as blueprint and tRNAs delivering amino acids. However, the natural ability of ribosomes is limited to 20 L-amino acids. Non-ribosomal peptide synthetases (NRPSs) synthesize only small peptides, however, from a large number of natural and non-proteinogenic amino acids. with non-proteinogenic amino acids.
SURFkiller The work with genetically modified organisms (GMOs) harbours the risk of their release into nature. Therefore, it is necessary to make their survival in nature impossible.We developed a security system for Bacillus subtilis which based on one of the cells essential compartment the ribosome.
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