Your team has been approved and you are ready to start the iGEM season!
On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world!
By harnessing the inherent ability of facultative anaerobic bacteria to colonize and grow in tumoral environments, this project aims to develop a bacterial cancer therapy. A genetically modified E. coli strain will have knockouts in the lpp and msbB genes, which encode for the Braun’s lipoprotein and for the myristic acid moiety transporter of the lipopolysaccharide, respectively. These genes are known to trigger an immune response in the human body; by deleting them, the impact originating from a bacterial intravenous administration will be reduced. Furthermore, these bacteria will produce M13-modified bacteriophages under the control of a quorum sensing system. The resulting phages will be capable of binding to the GRP78 receptor, which is usually overexpressed in cancerous cells. Subsequently, they will internalize and transfect the cancerous cells with two different genes: apoptin, responsible for an apoptotic protein specific for cancerous cells which will be regulated by a constitutive promoter and a survivin siRNA. The latter will inhibit the uncontrollable growth characteristic of cancer cells, making them more vulnerable to apoptosis.
Requirements
Please be sure to keep these links, your audience will want to find your:
All pages must be created under the team’s name space.
As part of your documentation, keep the links from the menu to the left.
Do not use flash in wiki code.
The iGEM logo should be placed on the upper part of every page and should link to 2014.igem.org.
Visit the Wiki How To page for a complete list of requirements, tips and other useful information.
Tips
We are currently working on providing teams with some easy to use design templates.
In the meantime you can also view other team wikis for inspiration! Here are some very good examples
This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started:
State your accomplishments! Tell people what you have achieved from the start.
Be clear about what you are doing and what you plan to do.
You have a global audience! Consider the different backgrounds that your users come from.
Make sure information is easy to find; nothing should be more than 3 clicks away.
Avoid using very small fonts and low contrast colors; information should be easy to read.
Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the iGEM 2013 calendar
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