Team:UCSF UCB

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Abstract

Cells in a local population have a wide range of responses to a given stimulus. This noisiness may be due to differences in extracelluar environment, or intracellular molecular makeup. Yet these cells often need to coordinate and respond in a concerted way. For example, all T cells in a lymph node respond to an antigen, yet only those with a strong initial reaction proliferate and effect an immune response. In another example, V. fischeri sense local population levels and require quorum to express bioluminesence. Our project seeks to understand the complex intercellular interactions that must happen to produce such a specific community phenotype. Our goal is to investigate how a group of cells coordinate their behaviors using extracellular signaling by engineering essential coordination motifs.

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