Anti-Microbial Peptides

The natural tendency for P. acnes to reside in the skin makes P. acnes an ideal candidate for a skin probiotic. Using the transformation protocol optimized by our team, we can insert novel genes for beneficent functions into P. acnes. One such function is the secretion of an anti-microbial peptide, which would reduce inflammation by inhibiting the growth of bacteria in the area.

Cathelicidin is a natural antibiotic produced by the immune cells of many mammals, including humans. The antimicrobial peptide gene will be constructed into the plasmid along with an inducible blue-light promoter. If successful, the bacteria containing the plasmid will produce the cathelicidin when exposed to blue light and in turn suppress the P. acnes population when it becomes elevated.

Methods

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Timeline

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Results

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Conclusions

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