Team:MIT

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Improving the Diagnosis and Treatment of

ALZHEIMER'S DISEASE

[Dying Neuron]
Neurodegenerative Disease

[6th]
Leading cause of death in the US

[Vaccine]
Current diagnosis and therapeutics are not effective

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by memory loss, behavioral problems… There is currently no cure for this disease, and existing diagnosis methods leave much to be desired. MIT iGEM 2014 has set out to change this. By detecting molecular biomarkers for AD, such as miRNAs and neurotoxic beta-amyloid plaques, and by regulating the production of beta-amyloid plaques, MIT iGEM hopes to create a dynamic solution for patients with Alzheimer’s disease. Looking ahead, … delivery.
DETECT → TREAT → DELIVER

DETECTION
Natural AB receptor	Engineered AB receptor	Sensors for Alzheimer’s state

TREATMENT	DELIVERY

Regulate AB production and degradation	Ways to deliver our circuit

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