Team:KAIT JAPAN

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Project:Abstract

Hay fever curE.coli ~revenge~

I looked back at the failure of last year. I think it tries to complete this plan this year. Japanese on of six people is troubled now by hay fever. These people take a medicine for its. But, If they take it , they become sleepy. So we are working on a project to relive hay fever by E.Coli to improve these. Mechanism of hay fever When an allergen invades it in the living body, naïve T cell differentiates in Th2. There is more Th2 than Th1, and the mast cell and others that is humoral immunity become active, and inflammation is in this way caused. We perform following four this time. ①Expression of IL-10 receptor to E.coli. ②Phosphorylation of STAT3. ③Preparation of gene array with HlyA and L-12 promoter and receiving the STAT3. ④Preparation of gene array with TolC and HlyB and HlyD promoter and to receive the STAT3.

1. Expression of IL-10 receptor to E.coli.

2. Phosphorylation of STAT3.

3. Preparation of gene array with HlyA and L-12 promoter and receiving the STAT3.

4. Preparation of gene array with TolC and HlyB and HlyD promoter and to receive the STAT3.