Team:Warwick/Team2

From 2014.igem.org

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Revision as of 11:55, 1 August 2014

Welcome to the official Wiki of the first University of Warwick 2014 iGEM team. Our team consists of members from different disciplines all having a common interest in the area of Synthetic biology coming together to compete, collaborate and contribute! Small interfering RNAs (siRNAs) represent a diverse family of biological regulators that are able to bind specifically to mRNA and prevent translation. siRNAs have been used in reverse genetics to understand the function of genes in gene knock-out studies. It has become apparent from a clinical viewpoint that siRNAs represent one type of therapeutic against diseases which have abberant gene expression profilessuch as alzheimers and cancer. siRNAs work through a conserved evolutionariy mechanism, specific to eukaryotes that utilizes the enzyme RNAse type 3 enzyme Dicer, that is able to dice a siRNA

Our project involves the production of a self-replicating RNA system, utilizing the well characterized Hepatitis C virus subtype 1b RNA dependent RNA polymerase (RdRp). By using a number of different biological components, We wish to develop a system whereby small interfering RNAs (siRNAs) are produced intermittently; without having the need to systematically introduce siRNAs through injectable delievery into patients. As we circumvent the biological flow of information at the level of mRNA, our system overcomes the limitation of gene therapeutic methods which utilize vectors that routinely integrate into the host genome and can downregulate, or activate genes

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 <td style="border:1px solid black;" align="center" height ="60px" onMouseOver="this.bgColor='#d3d3d3'" onMouseOut="this.bgColor='#e7e7e7'" bgColor=#0174DF>
-<a href="https://2014.igem.org/Team:Warwick"style="color:#000000"> <b> Home </b> </a> </td>
+<a href="https://2014.igem.org/Team:Warwick"style="color:#000000"> <b>  </b> </a> <a href=https://2014.igem.org/Team:Warwick><img src="https://static.igem.org/mediawiki/2014/9/9a/Home.png" border="20" align=20px" height ="20px" alt="Image and video hosting by TinyPic">
+</h2></td></tr>
+<tr></td>
-<td style="border:1px solid black;" align="center" height ="60px" onMouseOver="this.bgColor='#d3d3d3'" onMouseOut="this.bgColor='#e7e7e7'" bgColor=#0174DF>
+<td style="border:1px solid black;" align="right" height ="60px" onMouseOver="this.bgColor='#d3d3d3'" onMouseOut="this.bgColor='#e7e7e7'" bgColor=#0174DF>
-<a href="https://2014.igem.org/Team:Warwick/Team"style="color:#000000"> <b> Team </b> </a> </td>
+<a href="https://2014.igem.org/Team:Warwick/Team"style="color:#000000"> <b>  </b> </a> <a href=https://2014.igem.org/Team:Warwick/Team><img src="https://static.igem.org/mediawiki/2014/0/01/Agents.png" border="20" align=20px" height ="20px" alt="Image and video hosting by TinyPic">
+</h2></td></tr>
+<tr></td>
-<td style="border:1px solid black;" align="center"  height ="60px"  onMouseOver="this.bgColor='#d3d3d3'" onMouseOut="this.bgColor='#e7e7e7'" bgColor=#0174DF>
+<td style="border:1px solid black;" align="right" height ="60px" onMouseOver="this.bgColor='#d3d3d3'" onMouseOut="this.bgColor='#e7e7e7'" bgColor=#0174DF>
-<a href="https://igem.org/Team.cgi?year=2014&team_name=Warwick"style="color:#000000"> <b> Official Team Profile </b> </a></td>
+<a href="https://2014.igem.org/Team:Warwick/Project"style="color:#000000"> <b>  </b> </a> <a href=https://2014.igem.org/Team:Warwick/Project><img src="https://static.igem.org/mediawiki/2014/9/92/Project.png" border="20" align=20px" height ="20px" alt="Image and video hosting by TinyPic">
+</h2></td></tr>
+<tr></td>
-<td style="border:1px solid black" align="center"  height ="60px" onMouseOver="this.bgColor='#d3d3d3'" onMouseOut="this.bgColor='#e7e7e7'" bgColor=#0174DF>
-<a href="https://2014.igem.org/Team:Warwick/Project"style="color:#000000"> <b> Project </b> </a></td>
-<td style="border:1px solid black;" align="center"  height ="60px" onMouseOver="this.bgColor='#d3d3d3'" onMouseOut="this.bgColor='#e7e7e7'" bgColor=#0174DF>
-<a href="https://2014.igem.org/Team:Warwick/Parts"style="color:#000000"> <b> Parts </b> </a></td>
-<td style="border:1px solid black;" align="center" height ="60px" onMouseOver="this.bgColor='#d3d3d3'" onMouseOut="this.bgColor='#e7e7e7'" bgColor=#0174DF>
+<td style="border:1px solid black;" align="right" height ="60px" onMouseOver="this.bgColor='#d3d3d3'" onMouseOut="this.bgColor='#e7e7e7'" bgColor=#0174DF>
-<a href="https://2014.igem.org/Team:Warwick/Modeling"style="color:#000000"> <b> Modeling </b> </a></td>
+<a href="https://2014.igem.org/Team:Warwick/Project"style="color:#000000"> <b>  </b> </a> <a href=https://2014.igem.org/Team:Warwick/Project><img src="https://static.igem.org/mediawiki/2014/7/79/Parts.png" border="20" align=20px" height ="20px" alt="Image and video hosting by TinyPic">
+</h2></td></tr>
+<tr></td>
-<td style="border:1px solid black;" align="center" height ="60px" onMouseOver="this.bgColor='#d3d3d3'" onMouseOut="this.bgColor='#e7e7e7'" bgColor=#0174DF>
-<a href="https://2014.igem.org/Team:Warwick/Notebook"style="color:#000000"> <b> Notebook </b> </a></td>
-<td style="border:1px solid black;" align="center"  height ="60px" onMouseOver="this.bgColor='#d3d3d3'" onMouseOut="this.bgColor='#e7e7e7'" bgColor=#0174DF>
+<td style="border:1px solid black;" align="right" height ="60px" onMouseOver="this.bgColor='#d3d3d3'" onMouseOut="this.bgColor='#e7e7e7'" bgColor=#0174DF>
-<a href="https://2014.igem.org/Team:Warwick/Safety"style=" color:#000000"> <b> Safety </b> </a></td>
+<a href="https://2014.igem.org/Team:Warwick/Project"style="color:#000000"> <b>  </b> </a> <a href=https://2014.igem.org/Team:Warwick/Modeling><img src="https://static.igem.org/mediawiki/2014/3/3c/Modeling.png" border="20" align=20px" height ="20px" alt="Image and video hosting by TinyPic">
+</h2></td></tr>
+<tr></td>
-<td style="border:1px solid black;" align="center"  height ="60px" onMouseOver="this.bgColor='#d3d3d3'" onMouseOut="this.bgColor='#e7e7e7'" bgColor=#0174DF>
-<a href="https://2014.igem.org/Team:Warwick/Attributions"style="color:#000000"> <b> Attributions </b> </a></td>
-<td style="border:1px solid black;" align="center"  height ="60px" onMouseOver="this.bgColor='#d3d3d3'" onMouseOut="this.bgColor='#e7e7e7'" bgColor=#0174DF>
-<a href="https://2014.igem.org/Team:Warwick/Measurements"style="color:#000000"> <b> Measurements </b> </a></td>
-<td align ="center"> <a href="https://2014.igem.org/Main_Page"> <img src="http://i57.tinypic.com/dnd4rb.jpg" width="55px"></a> </td>
+<td style="border:1px solid black;" align="right" height ="60px" onMouseOver="this.bgColor='#d3d3d3'" onMouseOut="this.bgColor='#e7e7e7'" bgColor=#0174DF>
+<a href="https://2014.igem.org/Team:Warwick/Project"style="color:#000000"> <b>  </b> </a> <a href=https://2014.igem.org/Team:Warwick/Notebook><img src="https://static.igem.org/mediawiki/2014/9/95/Notebook.png
+" border="20" align=20px" height ="20px" alt="Image and video hosting by TinyPic">
+</h2></td></tr>
+<tr></td>
+<td style="border:1px solid black;" align="right" height ="60px" onMouseOver="this.bgColor='#d3d3d3'" onMouseOut="this.bgColor='#e7e7e7'" bgColor=#0174DF>
+<a href=https://2014.igem.org/Team:Warwick/Safety><img src="https://static.igem.org/mediawiki/2014/8/84/Safety.png
+" border="20" align=20px" height ="20px" alt="Image and video hosting by TinyPic">
+</h2></td></tr>
+<tr></td>
+<td style="border:1px solid black;" align="right" height ="60px" onMouseOver="this.bgColor='#d3d3d3'" onMouseOut="this.bgColor='#e7e7e7'" bgColor=#0174DF>
+<a href=https://2014.igem.org/Team:Warwick/Attributions><img src="https://static.igem.org/mediawiki/2014/1/16/Sponsors.png
+" border="20" align=20px" height ="20px" alt="Image and video hosting by TinyPic">
+</h2></td></tr>
+<tr></td>
+<td style="border:1px solid black;" align="right" height ="60px" onMouseOver="this.bgColor='#d3d3d3'" onMouseOut="this.bgColor='#e7e7e7'" bgColor=#0174DF>
+<a href=https://2014.igem.org/Team:Warwick/Measurements><img src="https://static.igem.org/mediawiki/2014/b/b4/Measurements.png
+" border="20" align=20px" height ="20px" alt="Image and video hosting by TinyPic">
+</h2></td></tr>
+<tr></td>
+<td align ="center"> <a href="https://2014.igem.org/Main_Page"> <img src="http://i57.tinypic.com/dnd4rb.jpg" width="200px"></a> </td>
 </head>
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 <!--requirements section -->
 <tr><td colspan="3"> <h2>
-<a href="https://static.igem.org/mediawiki/2014/a/af/The_mission_font.png" target="_blank"><img src="https://static.igem.org/mediawiki/2014/a/af/The_mission_font.png" border="30" align=50px" height ="50px" alt="Image and video hosting by TinyPic">
+<a href="https://static.igem.org/mediawiki/2014/a/af/The_mission_font.png" target="_blank"><img src="https://static.igem.org/mediawiki/2014/4/42/Welcome.png" border="30" align=50px" height ="50px" alt="Image and video hosting by TinyPic">
 </h2></td></tr>
 <tr>
 <td width="45%"  valign="top">
-<p> Please be sure to keep these links, your audience will want to find your: </p>
-<!-- Links to other team pages -->
-<ul>
-<li><a href="https://2014.igem.org/Team:Warwick">Home</a> </li>
-<li><a href="https://2014.igem.org/Team:Warwick/Team">Team</a> </li>
-<li><a href="https://igem.org/Team.cgi?year=2013&team_name=Warwick">Official Team Profile</a> </li>
-<li><a href="https://2014.igem.org/Team:Warwick/Project">Project</a> </li>
-<li><a href="https://2014.igem.org/Team:Warwick/Parts">Parts</a> </li>
-<li><a href="https://2014.igem.org/Team:Warwick/Modeling">Modeling</a> </li>
-<li><a href="https://2014.igem.org/Team:Warwick/Notebook">Notebook</a> </li>
-<li><a href="https://2014.igem.org/Team:Warwick/Safety">Safety</a> </li>
-<li><a href="https://2014.igem.org/Team:Warwick/Attributions">Attributions</a> </li>
-</ul>
 </td>
@@ Line 111: / Line 125: @@
 <td width="45%">
-<p>There are a few wiki requirements teams must follow:</p>
+<tr>
-<ul>
+<td width="45%"  valign="top">
-<li>All pages, images and files must be hosted on the <a href ="https://2014.igem.org/Special:Upload">  2014.igem.org server</a>. </li>
-<li>All pages must be created under the team’s name space.</li>
-<li>As part of your documentation, keep the links from the menu to the left. </li>
-<li>Do not use flash in wiki code. </li>
- <li>The <a href="https://static.igem.org/mediawiki/igem.org/6/60/Igemlogo_300px.png"> iGEM logo </a> should be placed on the upper part of every page and should link to <a href="https://2014.igem.org/Main_Page">2014.igem.org</a>.</li>
-</ul>
-<p>Visit the <a href="https://2014.igem.org/Wiki_How-To"> Wiki How To page </a> for a complete list of requirements, tips and other useful information. </p>
-</td>
-</tr>
+<center>
-<tr> <td colspan="3"  height="15px"> </td></tr>
+Welcome to the official Wiki of the first University of Warwick 2014 iGEM team. Our team consists of members from different disciplines all having a common interest in the area of Synthetic biology coming together to compete, collaborate and contribute!
-<tr><td bgColor="#e7e7e7" colspan="3" height="1"> </tr>
-<!--tips  -->
+Small interfering RNAs (siRNAs) represent a diverse family of biological regulators that are able to bind specifically to mRNA and prevent translation. siRNAs have been used in reverse genetics to understand the function of genes in gene knock-out studies. It has become apparent from a clinical viewpoint that siRNAs represent one type of therapeutic against diseases which have abberant gene expression profilessuch as alzheimers and cancer.
+siRNAs work through a conserved evolutionariy mechanism, specific to eukaryotes that utilizes the enzyme RNAse type 3 enzyme Dicer, that is able to dice a siRNA
+<img style="float: right; margin: 70px 70px 45px 45px;" src="https://static.igem.org/mediawiki/2014/8/8b/RISC.png" width="450" />
+Our project involves the production of a self-replicating RNA system, utilizing the well characterized Hepatitis C virus subtype 1b RNA dependent RNA polymerase (RdRp). By using a number of different biological components, We wish to develop a system whereby small interfering RNAs (siRNAs) are produced intermittently;  without having the need to systematically introduce siRNAs through injectable delievery into patients. As we circumvent the biological flow of information at the level of mRNA, our system overcomes the limitation of gene therapeutic methods which utilize vectors that routinely integrate into the host genome and can downregulate, or activate genes
+</center>
-<tr>
-<td width="45%" valign="top">
-<p>We are currently working on providing teams with some easy to use design templates.
-<br> In the meantime you can also view other team wikis for inspiration! Here are some very good examples</p>
-<ul>
-<li> <a href="https://2013.igem.org/Team:SDU-Denmark/"> 2013 SDU Denmark </a> </li>
-<li> <a href="https://2013.igem.org/Team:SYSU-China">2013 SYSU China</a> </li>
-<li> <a href="https://2013.igem.org/Team:Shenzhen_BGIC_ATCG"> 2013 Shenxhen BGIG ATCG </a></li>
-<li> <a href="https://2013.igem.org/Team:Colombia_Uniandes">2013 Colombia Unianades </a></li>
-<li> <a href="https://2013.igem.org/Team:Lethbridge">2013 Lethbridge</a></li>
-</ul>
-<p>For a full wiki list, you can visit <a href="https://igem.org/Team_Wikis?year=2013">iGEM 2013 web sites </a> and <a href="https://igem.org/Team_Wikis?year=2012">iGEM 2012 web sites</a>  lists. </p>
 </td>
-<td> </td>
+<a href="https://2014.igem.org/Team:Warwick on Make A Gif, Animated Gifs"><img src="http://cdn.makeagif.com/media/7-31-2014/9DG3Sj.gif" alt="9DG3Sj on Make A Gif, Animated Gifs"></a><div style="font-size:11px;"></a> </div>
-<td width="45%">
-<p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p>
-<ul>
-<li>State your accomplishments! Tell people what you have achieved from the start. </li>
-<li>Be clear about what you are doing and what you plan to do.</li>
-<li>You have a global audience! Consider the different backgrounds that your users come from.</li>
-<li>Make sure information is easy to find; nothing should be more than 3 clicks away.  </li>
-<li>Avoid using very small fonts and low contrast colors; information should be easy to read.  </li>
-<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="">iGEM 2013 calendar</a> </li>
-<li>Have lots of fun! </li>
-</ul>
-</br>
 </td>
 </tr>
-</table>
-<td style="border:1px solid black;" align="center" height ="60px" onMouseOver="this.bgColor='#d3d3d3'" onMouseOut="this.bgColor='#e7e7e7'" bgColor=#0174DF>
+<tr> <td colspan="3"  height="15px"> </td></tr>
+<tr><td bgColor="#e7e7e7" colspan="3" height="1"> </tr>
+<!--tips  -->
----
+</table>