Team:Groningen/Template/MODULE/Project/secretion/part4

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The anti-<i>staphylococcus aureus</i> secretion system:  
The anti-<i>staphylococcus aureus</i> secretion system:  
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</html>{{:Team:Groningen/Template/MODULE/newfigure|Figure 1|f/f2/Gen_constuct_5.art.png|The DspB and nisin construct}}<html>
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</html>{{:Team:Groningen/Template/MODULE/newfigure|Figure 2|f/f2/Gen_constuct_5.art.png|The DspB and nisin construct}}<html>
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Revision as of 03:14, 18 October 2014

The construct
In order to synchronize the secretion of infection preventing molecules with the detection of the certain pathogens, a few conditions must been set.

  • The construct should be regulated through detection.
  • It must secrete DspB when L. lactis senses both P. aeruginosa and S. aureus
  • It must secrete Aiia when it detect P. aeruginosa
  • It must secrete Nisin when it detects S. aureus

After designing the systems, two constructs came out: The anti-Pseudomonas aeruginosa system:
Figure 1
 
Figure 1: The DspB and AiiA construct
 
 
The anti-staphylococcus aureus secretion system:
Figure 2
 
Figure 2: The DspB and nisin construct