Team:Harvard BioDesign/Safety

From 2014.igem.org

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<p> Visit the <a href="https://2014.igem.org/Safety" >Safety Hub</a> to see this year's safety requirements. The Safety Hub is the central page for everything related to safety in iGEM. You can also go there to learn about general biosafety topics, and how to think about the future implications of your project.</p>
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  <p>This summer we worked in the Joshi Laboratory at the Wyss institute. It was a BSL-1 laboratory because we were working with non-infectious laboratory strains of E. coli. We work on open benches with latex gloves, often using Bunsen Burners to sterilize the areas around where we are working.</p>
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<h3> Edit this page!</h3>
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Please use this page to write about anything related to safety in your project. <!--Be sure to talk about both
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<li> <a href=" ">Learn about lab Safety for Today</a></li>
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<li> <a href="">Learn about Safety for the future of your project.</a></li>
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<h3> Your Lab </h3>
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<p> Use this section to tell us about your laboratory. Where is it located? What sort of equipment do you use every day? Have you decorated it for the summer? How do you look wearing a lab coat? Take pictures! Show off your space! </p>
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Image:Example2_Lab_1.png|The building our lab is in!
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Image:Example2_Lab_2.png|The inside of our lab!
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Image:Example2_Lab_3.png|Team Member 3 doing an experiment
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Image:Example2_Lab_4.png|Working in biosafety cabinets
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Image:Example2_Lab_5.png|Team all gloved up and ready for work!
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Image:Example2_Lab_6.png|Equipment that we use to do SCIENCE!
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Image:Example2_Lab_7.png|We decorated this part of our lab
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Image:Example2_Lab_8.png|Whatever else you want
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                  <p>We understand that curli is a pyrogenic agent, and can induce a potentially harmful immune response in humans. As such, any deployment or application of our information storage system would have to take precautions necessary to prevent contact between the curli-containing system and any open cuts, sores, or other points of access into the human bloodstream. </p>
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<li> <b>Now :</b>  Read the <a href="https://2014.igem.org/Safety">Safety Hub </a> and learn about safety in iGEM. Ask questions by emailing safety at <i> igem DOT org </i>. </li>
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                  <p>One question our team considered this summer was the potential spread of our transgenic plasmids into an ecosystem in which the system might be deployed. If this system were to be deployed, a number of strategies could be used to prevent the spread of our genetically engineered plasmids into the environment. Given that our system takes advantage of multiple distinct plasmids, we could engineer each plasmid to express a gene product that induces the other plasmids to express products that ensure they are kept in the cell (i.e., various antibiotic-resistance genes). That way, if one of the plasmids escaped from one of our engineered cells into a wild-type cell in the environment, it would find itself without the inducers necessary to allow it to be duplicated and kept by the wild-type cell it had entered. </p>
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<li><b>Now - Jamboree:</b> Complete <b>Check-Ins</b> and receive approval before acquiring and using certain materials in your lab</li>
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                  <h5>&nbsp;</h5>
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<li><b>Now - Wiki Freeze:</b> Edit this Safety page to tell us about what you're doing</li>
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<li><b>June 9: </b>Submit the About Our Lab form.</li>
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<li><b>Let us know by June 25 </b>if you will need an extension on the Preliminary Version, or your Preliminary Version will be significantly incomplete.</li>
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<li><b>June 30: </b>Submit the Preliminary Version of the <b>Safety Form</b>.</li>
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<li>Participate in Virtual Open Office Hours to ask questions and discuss safety topics (exact date to be determined).</li>
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<li><b>September 1:</b> Submit the Final Version of the Safety Form.</li>
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<li><b>October: </b> Wiki freeze (exact date to be determined)</li>
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<li><b>October 30 - November 3: </b>GIANT JAMBOREE!</li>
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Revision as of 23:31, 17 October 2014



HARVARD iGEM 2014!

SAFETY


Click here to edit this page!

Home Team Official Team Profile Project Parts Modeling Notebook Safety Attributions

Safety!

Human Practices

This summer we worked in the Joshi Laboratory at the Wyss institute. It was a BSL-1 laboratory because we were working with non-infectious laboratory strains of E. coli. We work on open benches with latex gloves, often using Bunsen Burners to sterilize the areas around where we are working.

We understand that curli is a pyrogenic agent, and can induce a potentially harmful immune response in humans. As such, any deployment or application of our information storage system would have to take precautions necessary to prevent contact between the curli-containing system and any open cuts, sores, or other points of access into the human bloodstream. 


One question our team considered this summer was the potential spread of our transgenic plasmids into an ecosystem in which the system might be deployed. If this system were to be deployed, a number of strategies could be used to prevent the spread of our genetically engineered plasmids into the environment. Given that our system takes advantage of multiple distinct plasmids, we could engineer each plasmid to express a gene product that induces the other plasmids to express products that ensure they are kept in the cell (i.e., various antibiotic-resistance genes). That way, if one of the plasmids escaped from one of our engineered cells into a wild-type cell in the environment, it would find itself without the inducers necessary to allow it to be duplicated and kept by the wild-type cell it had entered. 

 

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