Talk:Team:UMayor-Chile/Modeling

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<h1 >WELCOME TO iGEM 2014! </h1>
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<p>Your team has been approved and you are ready to start the iGEM season!
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<br>On this page you can document your project, introduce your team members, document your progress <br> and share your iGEM experience with the rest of the world! </p>
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<p style="color:#E7E7E7"> <a href="https://2014.igem.org/wiki/index.php?title=Team:UMayor-Chile/Modeling&action=edit"style="color:#FFFFFF"> Click here  to edit this page!</a> </p>
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      <div class="gwd-div-613s"><span class="gwd-span-29s7">The Cystic fibrosis</span>
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      <div class="gwd-div-r143"><span class="gwd-span-w7i9">(CF)</span>
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      <p class="MsoNormal"><span lang="EN-US"><span class="gwd-span-qyko">70,000
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people with CF worldwide, a lifespan depending of the resources (in USA the
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lifespan it’s about 40 years old, while in Chile the average lifespan it’s
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about 18 years old)</span>
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        <o:p></o:p>
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      <header><span class="gwd-span-dpni"><span class="gwd-span-oil2">Scene from Patient Assistance Resource Center video (Youtube). Cystic Fibrosis Foundation.</span></span>
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      <div class="gwd-div-oqkz"><span class="gwd-span-18v6">It’s a disease caused by the expression of a deficient transmembrane protein called CFTR. This affects different kind of cells, mainly the epithelial cells from the airway and pancreas, causing the production of a defective mucus.</span>
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      <div class="gwd-div-5qz9"><span class="gwd-span-28a8">&nbsp;In the lungs, this defective mucus leads that several opportunistic pathogens enter to the lower airway and initiate an infection, with a consecutively progressive lung dysfunction.</span>
 
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<a href="https://2014.igem.org/Team:UMayor-Chile"style="color:#000000">Home </a> </td>
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      <div class="gwd-div-blee">
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        <div><span class="gwd-span-8mg1">One of the main pathogens found in an infection of the lungs are the Pseudomonas aeruginosa. When it colonize the airway, initiates the production of biofilm, a barrier that protect it of a lot of antimicrobial substances and gave best environment for it develop.</span>
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        <div><span class="gwd-span-jzb2"><br></span>
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        <div><span class="gwd-span-p2cw">&nbsp;The actual treatments for controlling the symptoms consist in maintain controlled the pathogens, clear the airway of the sticky mucus, administrate complementary enzymes and regulate the function of the CFTR channel.&nbsp;</span>
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    <div class="gwd-div-fpj0"></div>
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    <div class="gwd-div-dv2k">
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      <div>Say goodbye everybody, the antibiotics are now available:</div>
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      <div>
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        <br>
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      </div>
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      <div>&nbsp;There’s no protection of the biofilm. Both P. aeruginosa and our E. coli Troyhorse are exposed to the final cut… a massive antibiotic attack!!!</div>
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    </div>
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    <div class="gwd-div-9nzr gwd-div-s608">
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      <p class="MsoNormal gwd-p-80ei"><span lang="EN-US" class="gwd-span-vr7b gwd-span-ub7k gwd-span-8o5j">Well, here
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we are… it’s time to start the part II:<o:p></o:p></span>
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      </p>
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      <p class="MsoNormal"><span lang="EN-US"><span class="gwd-span-0kuj">&nbsp; Our E. coli tryhorse now know they are in the
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zone. It’s time to start the attack. Our enemy are protected by his thick barrier
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and our warriors know his weak point.&nbsp;</span>
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        <o:p></o:p>
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      <p class="MsoNormal gwd-p-rn6j"><span lang="EN-US"><strong>Our
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troyhorse warriors have a plan!!</strong><o:p></o:p></span>
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    <div class="gwd-div-hc77">
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      <p class="MsoNormal"><span lang="EN-US" class="gwd-span-k5x7">&nbsp;The first part of the plan is simple: looking
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for the Biofilm fortress.<o:p></o:p></span>
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      </p>
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      <p class="MsoNormal"><span lang="EN-US"><span class="gwd-span-dkqs">&nbsp;&nbsp; We have to find our enemy. Our warriors will
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to enter to the fortress been guide by the clues left by our enemies, the
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Pseudomonas aeruguinosa.</span>
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        <o:p></o:p>
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    <div class="gwd-div-09ev">
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      <div><span class="gwd-span-bmgn">They are under attack!!! Pseudomonas are communicating themselves for rebuild the biofilm:</span>
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      <div><span class="gwd-span-t4xf"><br></span>
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      <div><span class="gwd-span-7ci1">&nbsp; We have to cut the communications between the Pseudomonas as an intelligent strategy. The biofilm it’s a community work. If they can´t send signals, they won’t work in community.</span>
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      </div>
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    </div>
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    <div class="gwd-div-1trz">
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      <div>Our troyhorse warriors have a plan!!</div>
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      <div>
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        <br>
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      <div>We propose smart warriors E. coli for the battle against the P. aeruginosa. We are training them now, teaching the action plan!!! Pay attention...</div>
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<a href="https://2014.igem.org/Team:UMayor-Chile/Team"style="color:#000000"> Team </a> </td>
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<a href="https://igem.org/Team.cgi?year=2014&team_name=UMayor-Chile"style="color:#000000"> Official Team Profile </a></td>
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<td style="border:1px solid black" align="center"  height ="45px" onMouseOver="this.bgColor='#d3d3d3'" onMouseOut="this.bgColor='#e7e7e7'" bgColor=#e7e7e7> 
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<a href="https://2014.igem.org/Team:UMayor-Chile/Project"style="color:#000000"> Project</a></td>
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<a href="https://2014.igem.org/Team:UMayor-Chile/Parts"style="color:#000000"> Parts</a></td>
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<a href="https://2014.igem.org/Team:UMayor-Chile/Modeling"style="color:#000000"> Modeling</a></td>
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<a href="https://2014.igem.org/Team:UMayor-Chile/Notebook"style="color:#000000"> Notebook</a></td>
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<a href="https://2014.igem.org/Team:UMayor-Chile/Safety"style=" color:#000000"> Safety </a></td>
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<a href="https://2014.igem.org/Team:UMayor-Chile/Attributions"style="color:#000000"> Attributions </a></td>
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<td align ="center"> <a href="https://2014.igem.org/Main_Page"> <img src="https://static.igem.org/mediawiki/igem.org/6/60/Igemlogo_300px.png" width="55px"></a> </td>
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<!--modeling content -->
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<tr><td colspan="3"> <h3>Modeling</h3></td></tr>
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<td width="45%"  valign="top">
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<p>If you choose to create a model during your project, please write about it here. Modeling is not an essential part of iGEM, but we encourage any and all teams to model some aspect of their project. See previous "Best Model" awards for more information.</p>
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Latest revision as of 23:09, 17 October 2014



WELCOME TO iGEM 2014!

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and share your iGEM experience with the rest of the world!


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Home Team Official Team Profile Project Parts Modeling Notebook Safety Attributions

Modeling

If you choose to create a model during your project, please write about it here. Modeling is not an essential part of iGEM, but we encourage any and all teams to model some aspect of their project. See previous "Best Model" awards for more information.

Retrieved from "http://2014.igem.org/Talk:Team:UMayor-Chile/Modeling"