Talk:Team:UMayor-Chile/Modeling

From 2014.igem.org

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       </div>
       </div>
       <img src="https://static.igem.org/mediawiki/2014/e/e9/Imagen1eng.png" class="gwd-img-3217 gwd-group-nq40" data-gwd-style="" data-gwd-override-style="" style="">
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       <div class="gwd-div-blee">
-
         <p class="MsoNormal"><span lang="EN-US" class="gwd-span-1esd">One of the
+
         <div><span class="gwd-span-8mg1">One of the main pathogens found in an infection of the lungs are the Pseudomonas aeruginosa. When it colonize the airway, initiates the production of biofilm, a barrier that protect it of a lot of antimicrobial substances and gave best environment for it develop.</span>
-
main pathogens found in an infection of the lungs are the Pseudomonas
+
         </div>
-
aeruginosa. When it colonize the airway, initiates the production of biofilm, a
+
         <div><span class="gwd-span-jzb2"><br></span>
-
barrier that protect it of a lot of antimicrobial substances and gave best environment
+
        </div>
-
for it develop.<o:p></o:p></span>
+
        <div><span class="gwd-span-p2cw">&nbsp;The actual treatments for controlling the symptoms consist in maintain controlled the pathogens, clear the airway of the sticky mucus, administrate complementary enzymes and regulate the function of the CFTR channel.&nbsp;</span>
-
 
+
        </div>
-
         </p>
+
      </div>
-
         <p class="MsoNormal"><span lang="EN-US"><span class="gwd-span-4ix6">&nbsp;The actual treatments for controlling the symptoms
+
    </div>
-
consist in maintain controlled the pathogens, clear the airway of the sticky
+
    <div class="gwd-div-fpj0"></div>
-
mucus, administrate complementary enzymes and regulate the function of the CFTR
+
    <div class="gwd-div-dv2k">
-
channel.&nbsp;</span>
+
      <div>Say goodbye everybody, the antibiotics are now available:</div>
-
 
+
      <div>
-
          <o:p></o:p>
+
        <br>
-
          </span>
+
      </div>
-
         </p>
+
      <div>&nbsp;There’s no protection of the biofilm. Both P. aeruginosa and our E. coli Troyhorse are exposed to the final cut… a massive antibiotic attack!!!</div>
 +
    </div>
 +
    <div class="gwd-div-9nzr gwd-div-s608">
 +
      <p class="MsoNormal gwd-p-80ei"><span lang="EN-US" class="gwd-span-vr7b gwd-span-ub7k gwd-span-8o5j">Well, here
 +
we are… it’s time to start the part II:<o:p></o:p></span>
 +
      </p>
 +
      <p class="MsoNormal"><span lang="EN-US"><span class="gwd-span-0kuj">&nbsp; Our E. coli tryhorse now know they are in the
 +
zone. It’s time to start the attack. Our enemy are protected by his thick barrier
 +
and our warriors know his weak point.&nbsp;</span>
 +
         <o:p></o:p>
 +
        </span>
 +
      </p>
 +
    </div>
 +
    <div class="gwd-div-30v9">
 +
      <p class="MsoNormal gwd-p-rn6j"><span lang="EN-US"><strong>Our
 +
troyhorse warriors have a plan!!</strong><o:p></o:p></span>
 +
      </p>
 +
    </div>
 +
    <div class="gwd-div-hc77">
 +
      <p class="MsoNormal"><span lang="EN-US" class="gwd-span-k5x7">&nbsp;The first part of the plan is simple: looking
 +
for the Biofilm fortress.<o:p></o:p></span>
 +
      </p>
 +
      <p class="MsoNormal"><span lang="EN-US"><span class="gwd-span-dkqs">&nbsp;&nbsp; We have to find our enemy. Our warriors will
 +
to enter to the fortress been guide by the clues left by our enemies, the
 +
Pseudomonas aeruguinosa.</span>
 +
        <o:p></o:p>
 +
        </span>
 +
      </p>
 +
    </div>
 +
    <div class="gwd-div-09ev">
 +
      <div><span class="gwd-span-bmgn">They are under attack!!! Pseudomonas are communicating themselves for rebuild the biofilm:</span>
 +
      </div>
 +
      <div><span class="gwd-span-t4xf"><br></span>
 +
      </div>
 +
      <div><span class="gwd-span-7ci1">&nbsp; We have to cut the communications between the Pseudomonas as an intelligent strategy. The biofilm it’s a community work. If they can´t send signals, they won’t work in community.</span>
 +
      </div>
 +
    </div>
 +
    <div class="gwd-div-1trz">
 +
      <div>Our troyhorse warriors have a plan!!</div>
 +
      <div>
 +
        <br>
       </div>
       </div>
 +
      <div>We propose smart warriors E. coli for the battle against the P. aeruginosa. We are training them now, teaching the action plan!!! Pay attention...</div>
     </div>
     </div>
   </body>
   </body>

Revision as of 23:07, 17 October 2014



asd2
The Cystic fibrosis
(CF)

70,000 people with CF worldwide, a lifespan depending of the resources (in USA the lifespan it’s about 40 years old, while in Chile the average lifespan it’s about 18 years old)

Scene from Patient Assistance Resource Center video (Youtube). Cystic Fibrosis Foundation.
It’s a disease caused by the expression of a deficient transmembrane protein called CFTR. This affects different kind of cells, mainly the epithelial cells from the airway and pancreas, causing the production of a defective mucus.

 In the lungs, this defective mucus leads that several opportunistic pathogens enter to the lower airway and initiate an infection, with a consecutively progressive lung dysfunction.
One of the main pathogens found in an infection of the lungs are the Pseudomonas aeruginosa. When it colonize the airway, initiates the production of biofilm, a barrier that protect it of a lot of antimicrobial substances and gave best environment for it develop.

 The actual treatments for controlling the symptoms consist in maintain controlled the pathogens, clear the airway of the sticky mucus, administrate complementary enzymes and regulate the function of the CFTR channel. 
Say goodbye everybody, the antibiotics are now available:

 There’s no protection of the biofilm. Both P. aeruginosa and our E. coli Troyhorse are exposed to the final cut… a massive antibiotic attack!!!

Well, here we are… it’s time to start the part II:

  Our E. coli tryhorse now know they are in the zone. It’s time to start the attack. Our enemy are protected by his thick barrier and our warriors know his weak point. 

Our troyhorse warriors have a plan!!

 The first part of the plan is simple: looking for the Biofilm fortress.

   We have to find our enemy. Our warriors will to enter to the fortress been guide by the clues left by our enemies, the Pseudomonas aeruguinosa.

They are under attack!!! Pseudomonas are communicating themselves for rebuild the biofilm:

  We have to cut the communications between the Pseudomonas as an intelligent strategy. The biofilm it’s a community work. If they can´t send signals, they won’t work in community.
Our troyhorse warriors have a plan!!

We propose smart warriors E. coli for the battle against the P. aeruginosa. We are training them now, teaching the action plan!!! Pay attention...

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