Team:HUST-Innovators

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<p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p>
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<!--<p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p>-->
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<li>State your accomplishments! Tell people what you have achieved from the start. </li>
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<li>You have a global audience! Consider the different backgrounds that your users come from.</li>
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<h style="font-size:30px; top:300px;" align="right">While the start of Synthetic Biology is the sequenced data from databases, if there are some new species whose genetic information is unknown, how can we continue the synthesis? Therefore, we decided to expand the definition and add modules of Synthetic Biology...<a style="font-weight:bold; font-style:oblique;" href="#" onclick="change('SeqevolutionforSB')">more</a></h><a style="font-weight:bold; font-style:oblique;" href="#" onclick="change('SeqevolutionforSB')">
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<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="">iGEM 2013 calendar</a> </li>
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<h3>Overture(IGS and Bioinformatics)</h3>
<h3>Overture(IGS and Bioinformatics)</h3>
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In 1977 Sanger and colleagues introduced the "dideoxy" chain-termination method for sequencing DNA molecules, also known as the "Sanger method".This was a major breakthrough and allowed long stretches of DNA to be rapidly and accurately sequenced. It earned him his second Nobel prize in Chemistry in 1980, which he shared with Walter Gilbert and Paul Berg.The new method was used by Sanger and colleagues to sequence human mitochondrial DNA (16,569 base pairs) and bacteriophage λ (48,502 base pairs).The dideoxy method was eventually used to sequence the entire human genome.
In 1977 Sanger and colleagues introduced the "dideoxy" chain-termination method for sequencing DNA molecules, also known as the "Sanger method".This was a major breakthrough and allowed long stretches of DNA to be rapidly and accurately sequenced. It earned him his second Nobel prize in Chemistry in 1980, which he shared with Walter Gilbert and Paul Berg.The new method was used by Sanger and colleagues to sequence human mitochondrial DNA (16,569 base pairs) and bacteriophage λ (48,502 base pairs).The dideoxy method was eventually used to sequence the entire human genome.
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As the accumulation of sequence data, databases formed, which announced the birth of the bioinformatics.
As the accumulation of sequence data, databases formed, which announced the birth of the bioinformatics.
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<h3>Sonata(NGS and Synthetic Biology)</h3>
<h3>Sonata(NGS and Synthetic Biology)</h3>
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In short, the First GS has some fatal drawbacks such as high cost and low throughput. This is why it was replaced by NGS, such as 454, Solexa, Hiseq, etc.  The NGS has distinct effects on cost-reduction and time-saving with high accuracy. For instance, it took only one week to finish the human genome project by NGS, while the time using by First GS is 3 years.
In short, the First GS has some fatal drawbacks such as high cost and low throughput. This is why it was replaced by NGS, such as 454, Solexa, Hiseq, etc.  The NGS has distinct effects on cost-reduction and time-saving with high accuracy. For instance, it took only one week to finish the human genome project by NGS, while the time using by First GS is 3 years.
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As more and more species were sequenced, the size of genomic data is enlarged. As is known, the sequence of species is the major prerequisite of the SB. So the conclusion is drawn that the emergence of the NGS indicated the naissance of SB.
As more and more species were sequenced, the size of genomic data is enlarged. As is known, the sequence of species is the major prerequisite of the SB. So the conclusion is drawn that the emergence of the NGS indicated the naissance of SB.
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<h3>cadenza (III GS and ???)</h3>
<h3>cadenza (III GS and ???)</h3>
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That is why we start our project this year.
That is why we start our project this year.
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<h4>Docosahexaenoic Acid</h4>
<h4>Docosahexaenoic Acid</h4>
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Docosahexaenoic acid (DHA) is an omega-3 fatty acid that is a primary structural component of the human brain, cerebral cortex, skin, sperm, testicles and retina. It can be synthesized from alpha-linolenic acid or obtained directly from maternal milk or fish oil. DHA's structure is a carboxylic acid with a 22-carbon chain and six  cis double bonds; with the first double bond located at the third carbon from the omega end. Its trivial name is cervonic acid, its systematic name is all-cis-docosa-4,7,10,13,16,19-hexa-enoic acid, and its shorthand name is 22:6(n-3) in the nomenclature of fatty acids.
Docosahexaenoic acid (DHA) is an omega-3 fatty acid that is a primary structural component of the human brain, cerebral cortex, skin, sperm, testicles and retina. It can be synthesized from alpha-linolenic acid or obtained directly from maternal milk or fish oil. DHA's structure is a carboxylic acid with a 22-carbon chain and six  cis double bonds; with the first double bond located at the third carbon from the omega end. Its trivial name is cervonic acid, its systematic name is all-cis-docosa-4,7,10,13,16,19-hexa-enoic acid, and its shorthand name is 22:6(n-3) in the nomenclature of fatty acids.
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Cold-water oceanic fish oils are rich in DHA. Most of the DHA in fish and multi-cellular organisms with access to cold-water oceanic foods originates from photosynthetic and heterotrophic microalgae, and becomes increasingly concentrated in organisms the further they are up the food chain. DHA is also commercially manufactured from microalgae: Crypthecodinium cohnii and another of the genus Schizochytrium. DHA manufactured using microalgae is vegetarian.  
Cold-water oceanic fish oils are rich in DHA. Most of the DHA in fish and multi-cellular organisms with access to cold-water oceanic foods originates from photosynthetic and heterotrophic microalgae, and becomes increasingly concentrated in organisms the further they are up the food chain. DHA is also commercially manufactured from microalgae: Crypthecodinium cohnii and another of the genus Schizochytrium. DHA manufactured using microalgae is vegetarian.  
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<h4> Thraustochytrids</h4>
<h4> Thraustochytrids</h4>
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Thraustochytrids is rich in oceanic environment. And they can produce large amount of DHA. However our strain T-roseum ATCC28210 was still not sequenced yet. It means our project was blocked if we used the traditional Synthetic Biology Methods. To achieve our goal, we need to do something before the Traditional Process.
Thraustochytrids is rich in oceanic environment. And they can produce large amount of DHA. However our strain T-roseum ATCC28210 was still not sequenced yet. It means our project was blocked if we used the traditional Synthetic Biology Methods. To achieve our goal, we need to do something before the Traditional Process.
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Revision as of 03:43, 17 October 2014






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While the start of Synthetic Biology is the sequenced data from databases, if there are some new species whose genetic information is unknown, how can we continue the synthesis? Therefore, we decided to expand the definition and add modules of Synthetic Biology...more