Team:Warwick/Parts/Aptazyme

From 2014.igem.org

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             <h1> APTAZYME </h1> <br> <br>-->
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             <h1> APTAZYME </h1> <br> <br>
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<h2> Click <a href="https://2014.igem.org/Team:Warwick/Parts">here</a> to learn about our Aptazyme. </h2> <br><br>
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<h2> Click <a href="http://parts.igem.org/Part:BBa_K1442006">here</a> to learn about our Aptazyme. </h2> <br><br>
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<!--<p>An aptazyme is an allosteric ribozyme acting as a regulatory riboswitch. It self-splices in response to theophylline, a drug used to treat asthma and other chronic obstructive pulmonary diseases acting as a bronchodilator. This differs from caffeine by one methyl group and a nitrogen atom creating the structure seen below. This is not endogenous to the body therefore we used this element as a "kill switch" for our system.</p>-->
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    <p>This is an RNA enzyme which self-
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cleaves in the presence of
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theophylline. Theophylline is not  
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endogenous to mammalian cells
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hence acts as a selective “off-switch”
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in an instance such as, Hepatitis C
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infection or tumour formation which
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is exacerbated by lack of DPP-IV.</p>

Revision as of 23:26, 16 October 2014

APTAZYME



Click here to learn about our Aptazyme.



This is an RNA enzyme which self- cleaves in the presence of theophylline. Theophylline is not endogenous to mammalian cells hence acts as a selective “off-switch” in an instance such as, Hepatitis C infection or tumour formation which is exacerbated by lack of DPP-IV.

Retrieved from "http://2014.igem.org/Team:Warwick/Parts/Aptazyme"