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Team:UMaryland/project/overview
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class="yjm_title">Meet Our Team Members</span></span></a></span></li><li class="item116 level1"><span class="mymarg"><a class="yjanchor " href="https://igem.org/Team.cgi?id=1489"><span class="yjm_has_none"><span class="yjm_title">iGEM Page</span></span></a></span></li><li class="item117 level1"><span class="mymarg"><a class="yjanchor " href="https://2014.igem.org/Team:UMaryland/team/attributions"><span class="yjm_has_none"><span class="yjm_title">Attributions</span></span></a></span></li><li class="item300 level1 lilast"><span class="mymarg"><a class="yjanchor last" href="https://2014.igem.org/Team:UMaryland/team/sponsors"><span class="yjm_has_none"><span class="yjm_title">Sponsors</span></span></a></span></li><li class="right"></li><li class="br"></li></ul></li><li class=" active haschild item112 level0"><span class="child"><a class="yjanchor activepath yjscroll" href="https://2014.igem.org/Team:UMaryland/project/overview"><span class="yjm_has_none"><span class="yjm_title">Project</span></span></a></span><ul class="subul_main level1"><li class="bl"></li><li class="tl"></li><li class="tr"></li><li id="current" class=" active item138 level1 first"><span class="mymarg"><a class="yjanchor first activepath " href="https://2014.igem.org/Team:UMaryland/project/overview"><span class="yjm_has_none"><span class="yjm_title">Overview</span></span></a></span></li><li class="item145 level1"><span class="mymarg"><a class="yjanchor " href="https://2014.igem.org/Team:UMaryland/project/background"><span class="yjm_has_none"><span class="yjm_title">Background</span></span></a></span></li><li class="item144 level1"><span class="mymarg"><a class="yjanchor " href="https://2014.igem.org/Team:UMaryland/project/biobricks"><span class="yjm_has_none"><span class="yjm_title">parts (BioBricks)</span></span></a></span></li><li class="item102 level1"><a class="yjanchor " href="https://2014.igem.org/Team:UMaryland/project/results" target="_blank" ><span class="yjm_has_none"><span class="yjm_title">Results</span></span></a></li><li class="item254 level1"><span class="mymarg"><a class="yjanchor " href="https://2014.igem.org/Team:UMaryland/project/futureapplications"><span class="yjm_has_none"><span class="yjm_title">future applications</span></span></a></span></li><li class="item301 level1 lilast"><span class="mymarg"><a class="yjanchor last" href="https://igem.org/Safety/Safety_Form?team_id=1489"><span class="yjm_has_none"><span class="yjm_title">Safety</span></span></a></span></li><li class="right"></li><li class="br"></li></ul></li><li class="haschild item234 level0"><span class="child"><a class="yjanchor " href="https://2014.igem.org/Team:UMaryland/notebook"><span class="yjm_has_none"><span class="yjm_title">Notebook</span></span></a></span><ul class="subul_main level1"><li class="bl"></li><li class="tl"></li><li class="tr"></li><li class="item303 level1 first lilast"><span class="mymarg"><a class="yjanchor firstlast" href="https://2014.igem.org/Team:UMaryland/notebook"><span class="yjm_has_none"><span class="yjm_title">Wetlab Notebook</span></span></a></span></li><li class="right"></li><li class="br"></li></ul></li><li class="haschild item123 level0"><span class="child"><a class="yjanchor " href="https://2014.igem.org/Team:UMaryland/humanprac/overview"><span class="yjm_has_none"><span class="yjm_title">Human Practices</span></span></a></span><ul class="subul_main level1"><li class="bl"></li><li class="tl"></li><li class="tr"></li><li class="item106 level1 first"><span class="mymarg"><a class="yjanchor first" href="https://2014.igem.org/Team:UMaryland/humanprac/overview"><span class="yjm_has_none"><span class="yjm_title">Overview | Mission Statement</span></span></a></span></li><li class="haschild item129 level1"><span class="child subparent"><a class="yjanchor grouptitle" href="https://2014.igem.org/Team:UMaryland/humanprac/publicschool"><span class="yjm_has_none"><span class="yjm_title">Public School Outreach</span></span></a></span><ul class="subul_main level2"><li class="bl"></li><li class="tl"></li><li class="tr"></li><li class="item134 level2 first lilast"><span class="mymarg"><a class="yjanchor firstlast" href="https://2014.igem.org/Team:UMaryland/humanprac/publicschool"><span class="yjm_has_none"><span class="yjm_title">HighSchool</span></span></a></span></li><li class="right"></li><li class="br"></li></ul></li><li class="item131 level1"><span class="mymarg"><a class="yjanchor " href="https://2014.igem.org/Team:UMaryland/humanprac/community"><span class="yjm_has_none"><span class="yjm_title">Community Interaction</span></span></a></span></li><li class="item132 level1 lilast"><span class="mymarg"><a class="yjanchor last" href="https://2014.igem.org/Team:UMaryland/humanprac/publicawareness"><span class="yjm_has_none"><span class="yjm_title">Public Awareness</span></span></a></span></li><li class="right"></li><li class="br"></li></ul></li></ul></div> |
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Revision as of 22:19, 16 October 2014
Overview
Overview
The UMaryland iGem team opted for a project that hits close to home; with the Chesapeake Bay in our backyard, we have the potential to make a direct impact on the community. As Maryland’s most important natural landmark, the Chesapeake Bay is an integral part of our state’s identity. The bay is home to a diverse ecosystem, and is an economic boon to the area, supporting both the seafood industry and local tourism. Since the health of the bay is important, we looked into current problems in need of attention. In particular, the predicament of the Chesapeake’s oysters piqued our interest. As oyster populations declined over the years, the absence of this filtration system left a host of problems, including decreased water clarity and rising chemical pollutant levels. If the oyster populations can be maintained, it will improve the overall health of the Chesapeake. One way to combat oyster fatalities is to develop a way to monitor Dermo infestations.
Applications in the lab
It is believed that P. marinus enters oyster hemocytes utilizing a galectin on the cell’s surface, CvGal1, that allows binds preferentially to P. marinus. Our aim is to exploit CvGal1’s ability to bind to P. marinus in order to design a biosensor for the parasite. By expressing the galectin on the surface of E. coli and triggering a signal transduction cascade within the bacterial cell, the E. coli could produce Green Fluorescent Protein. Thus, P. marinus binding to CvGal1 would trigger the expression of GFP within E. coli, creating a visual marker for the parasite. The majority of this project will be accomplished through genetic cloning and bacterial transformation. Although laboratory methods for Dermo detection using Polymerase Chain Reaction exist, they are currently not capable of detecting the disease in real time. In the time needed to conduct a laboratory test, Dermo could have easily spread to new locations. This biosensor would help to accurately pinpoint Dermo infestation levels in real time. If we can pinpoint the location of Dermo, as elucidated in this research proposal, then we can ultimately develop a biosensor that can react to Dermo with targeted destruction.
Brief overview of servicing the community
We having been traveling around Maryland conducting various community outreach efforts by visiting local schools and oyster farms. During each visit, members present our project and spread awareness on the current state of the Chesapeake Bay, as well as ways individuals can help service the Bay. Some presentations are made on synthetic biology to increase student participation and interest in the sciences. We also have a committee dedicated to creating an educational computer game that teaches others about the issues that the Chesapeake Bay currently faces. It is our team’s hope that our research results to be presented at the iGEM jamboree will have a profound and positive impact on the health of the Chesapeake Bay and oyster populations worldwide
About Umaryland
UMaryland2014 is University of Maryland, College Parks, inaugural iGEM team. We are a combined effort of several departments and numerous faculty mentors. Although it is only our first year, believe our hard work and dedication has paid off. We can't wait for this years competition! GO TERPS!
