Team:Uppsala/Modeling PopulationLevel
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- | document.getElementById("tab1").innerHTML = '<h2>Introduction</h2><p>We wanted to evaluate the effectiveness of our system in the real intestine of a human. Since it requires a lot of ethical consideration and animal trials to test on real humans we decided to construct a model instead. The model will also give us insight into what parameters are most important when improving our system. Since the thought out medicine is thought of as a pill, see Policy & Practise, this is the premiss we will evaluate our modeling around.<br><br>Our final model is able to produce both a “density map” showing the small intestine as a two dimensional landscape and graphs of the total amount of cells and molecules over time. The first model is more heavy to run and can therefore only run at limited time intervals, while the later model is able to run at much longer intervals. The density map is good for analysing movement of molecules and cells in the domain, while the graphs are nice to show total effect of the system.</p><h2>Design</h2><p>To create our model we created a set of PDE:s to represent our system, see figure 1. The change of state is determined via a set of heaviside step functions(noted as theta) that are controlled by threshold concentrations noted as K_i, where i indicates which density is related to the threshold. Y.enterocolitica have been found to be immobile at 37 degrees celsius and do therefore not have a diffusion term. All parameters are defined in figure 2. You can read more about our design under the design page.</p>'; | + | document.getElementById("tab1").innerHTML = '<h2>Introduction</h2><p>We wanted to evaluate the effectiveness of our system in the real intestine of a human. Since it requires a lot of ethical consideration and animal trials to test on real humans we decided to construct a model instead. The model will also give us insight into what parameters are most important when improving our system. Since the thought out medicine is thought of as a pill, see Policy & Practise, this is the premiss we will evaluate our modeling around.<br><br>Our final model is able to produce both a “density map” showing the small intestine as a two dimensional landscape and graphs of the total amount of cells and molecules over time. The first model is more heavy to run and can therefore only run at limited time intervals, while the later model is able to run at much longer intervals. The density map is good for analysing movement of molecules and cells in the domain, while the graphs are nice to show total effect of the system.</p><h2>Design</h2><p>To create our model we created a set of PDE:s to represent our system, see figure 1. The change of state is determined via a set of heaviside step functions(noted as theta) that are controlled by threshold concentrations noted as K_i, where i indicates which density is related to the threshold. Y.enterocolitica have been found to be immobile at 37 degrees celsius and do therefore not have a diffusion term. All parameters are defined in figure 2. You can read more about our design under the design page.</p><br><table id="partsT"><tr><th>Parameter</th><th>Value</th><th>Source</th></tr><tr><td>D_b</td><td>3*10^-4 mm^2/s</td><td>5</td></tr><tr><td>D_c</td><td>4.2*10^-5 mm^2/s</td><td>1</td></tr><tr><td>D_o</td><td>4.9*10^-6 mm^2/s</td><td>2</td></tr><tr><td>K_c</td><td>2.25*10^-7 molecules/mL</td><td>3</td></tr><tr><td>K_a</td><td>10^-8 molecules/mL</td><td>est.</td></tr><tr><td>beta_c</td><td>15.625 s^-1</td><td>1</td></tr><tr><td>beta_o</td><td>1 s^-1</td><td>est.</td></tr><tr><td>etac</td><td>1/1200</td><td>ets.</td></tr><tr><td>eta_o</td><td>1/1200</td><td>4</td></tr></table><p><i>Figure 2: Table of parameter values</i></p>'; |
Revision as of 22:10, 16 October 2014
Stephanie Herman
Teresa Reinli
Joakim Hellner
Alexander Virtanen
Jennifer Rosenius
Marcus Hong
Miranda Stiernborg
Tim Hagelby Edström
Viktor Blomkvist
Megha Biradar
Niklas Handin
Jonas Mattisson
Arina Gromov
Nils Anlind
Eric Sandström
Gunta Celma
Oliver Possnert
Martin Friberg
Kira Karlsson
Christoffer Andersson
Laura Pacoste
Andries Willem Boers
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