Which are your personal concerns about safety in synthetic biology? To what extent have scientists to think about biosafety?

To answer this in detail we will have to wait into which direction research develops and which fields of application are exploited. But broadly speaking the high intrusion depth of synthetic biology into the genomes of organisms poses new safety questions.

Why does especially synthetic biology evoke the necessity to address biosafety questions in addition to the ongoing genetic engineering -safety-debate?

This is something which correlates with the depth of intrusion. This means the distance to the original organism is even bigger in synbio than in genetic engineering (größer als wir das von der gentechnik kennen). In genetic engineering there is always the an organism which can be compared (vergleichsorganismus) which is known very well so that it is possible to say the genetically engineered version of this organism will behave in the same ways and only differ in in some minor respects. But when synthetic biology has the realistic vision of a whole new genome being redesigned (am reißbrett entwerfen) and inserted into a bacterial cell the question arises how we can evaluate how this organisms will behave and develop. Here we are lacking reference values and that is a difference to conventional genetic engineering. This is a new level in the respect of biosafety questions.