Team:ATOMS-Turkiye/asoMain

From 2014.igem.org

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   <li><img src="https://static.igem.org/mediawiki/2014/thumb/3/33/ATOMS-main-1.jpg/800px-ATOMS-main-1.jpg" title= "This is a test caption. For more info click this caption."></li>
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   <li><img src="https://static.igem.org/mediawiki/2014/thumb/3/33/ATOMS-main-1.jpg/800px-ATOMS-main-1.jpg" title= "Our vessel tissue consists of three layers mainly: endothelium, muscular layer and outer layer. Nutrients and oxygen can pass through these layer to reach in other tissues."></li>
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  <li><img src="https://static.igem.org/mediawiki/2014/thumb/6/6c/ATOMS-main-2.jpg/800px-ATOMS-main-2.jpg" title= "This is a test caption. For more info click this caption."></li>
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  <li><img src="https://static.igem.org/mediawiki/2014/thumb/6/6c/ATOMS-main-2.jpg/800px-ATOMS-main-2.jpg" title= "In some cases such as excessive body weight or diabetes, fat accumulation may occur onto the endothelium which forms "plaques" in time. "></li>
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  <li><img src="https://static.igem.org/mediawiki/2014/thumb/8/84/ATOMS-main-3.jpg/800px-ATOMS-main-3.jpg" title= "This is a test caption. For more info click this caption."></li>
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  <li><img src="https://static.igem.org/mediawiki/2014/thumb/8/84/ATOMS-main-3.jpg/800px-ATOMS-main-3.jpg" title= "This plaques may continue to grow and widen which ends up with narrowing of the lumen of vessel that decreases blood flow into the tissues and increases the tension.
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  <li><img src="https://static.igem.org/mediawiki/2014/thumb/2/2a/ATOMS-main-4.jpg/800px-ATOMS-main-4.jpg" title= "This is a test caption. For more info click this caption."></li>
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"></li>
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  <li><img src="https://static.igem.org/mediawiki/2014/thumb/d/d7/ATOMS-main-5.jpg/800px-ATOMS-main-5.jpg" title= "This is a test caption. For more info click this caption."></li>
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  <li><img src="https://static.igem.org/mediawiki/2014/thumb/2/2a/ATOMS-main-4.jpg/800px-ATOMS-main-4.jpg" title= "This tension and other factors can result with the rupture of the plaques. This rupture then activates the coagulation cascade inside the blood."></li>
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  <li><img src="https://static.igem.org/mediawiki/2014/thumb/1/1b/ATOMS-main-6.jpg/800px-ATOMS-main-6.jpg" title= "This is a test caption. For more info click this caption."></li>
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  <li><img src="https://static.igem.org/mediawiki/2014/thumb/d/d7/ATOMS-main-5.jpg/800px-ATOMS-main-5.jpg" title= "Coagulation process ends with the formation of a clot. Due to other factors related with plaque formation, this clot tends to grow larger."></li>
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   <li><img src="https://static.igem.org/mediawiki/2014/thumb/1/15/ATOMS-main-7.jpg/800px-ATOMS-main-7.jpg" title= "This is a test caption. For more info click this caption."></li>
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  <li><img src="https://static.igem.org/mediawiki/2014/thumb/1/1b/ATOMS-main-6.jpg/800px-ATOMS-main-6.jpg" title= "Sometimes this clot may block the bloodstream completely. This results with the disruption of blood supply to the distal tissue."></li>
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   <li><img src="https://static.igem.org/mediawiki/2014/thumb/c/ca/ATOMS-main-8.jpg/800px-ATOMS-main-8.jpg" title= "This is a test caption. For more info click this caption."></li>
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   <li><img src="https://static.igem.org/mediawiki/2014/thumb/1/15/ATOMS-main-7.jpg/800px-ATOMS-main-7.jpg" title= "As blood contains oxygen and nutrient which are essential for energy production, tissue becomes depleted of energy and oxygen, which is called hypoxia. This may end with tissue death if it longs further."></li>
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<li><img src="https://static.igem.org/mediawiki/2014/thumb/f/fe/ATOMS-main-8a.jpg/800px-ATOMS-main-8a.jpg" title= "This is a test caption. For more info click this caption."></li>
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   <li><img src="https://static.igem.org/mediawiki/2014/thumb/c/ca/ATOMS-main-8.jpg/800px-ATOMS-main-8.jpg" title= "In our project, our engineered endothelial cells can sense this hypoxia in early stages and become activated to solve the problem."></li>
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   <li><img src="https://static.igem.org/mediawiki/2014/thumb/a/aa/ATOMS-main-9.jpg/800px-ATOMS-main-9.jpg" title= "This is a test caption. For more info click this caption."></li>
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<li><img src="https://static.igem.org/mediawiki/2014/thumb/f/fe/ATOMS-main-8a.jpg/800px-ATOMS-main-8a.jpg" title= "Engineered cells start to secrete clot dissolving factors into bloodstream to restore the blood supply to the tissue. Meanwhile they prepare for additonal damage to the oxidative burst after the restoration of oxygen."></li>
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   <li><img src="https://static.igem.org/mediawiki/2014/thumb/7/78/ATOMS-main-10.jpg/800px-ATOMS-main-10.jpg" title= "This is a test caption. For more info click this caption."></li>
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   <li><img src="https://static.igem.org/mediawiki/2014/thumb/a/aa/ATOMS-main-9.jpg/800px-ATOMS-main-9.jpg" title= "As clot becomes dissolved gradually, partial blood supply can be established which may cause oxidative burst. This effect is also prevented by our cells."></li>
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   <li><img src="https://static.igem.org/mediawiki/2014/thumb/7/78/ATOMS-main-10.jpg/800px-ATOMS-main-10.jpg" title= "With these sensing and protective systems, hypoxic conditions can be treated without the evaluation of clinical presence. "></li>
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Revision as of 00:47, 16 October 2014


Abstract

Tissue hypoxia, or ischemia, is the condition that describes the poor conveyance of oxygen and other vital products to body tissues and organs which consequently results tissue death. Up to now, the number one cause of death worldwide is caused by ischemia and related conditions such as heart attack or stroke. It is needed to regard the big picture of the condition in order to solve the problem. In our project, our will is to build two different devices, which work synergistically, to fix these two distinct situations. We decided to use ‘’hypoxia inducible systems” and ‘’reactive oxygen species (ROS) sensitive gene fragments’’. These two receptors will hopefully regulate the release of clot dissolving factors and antioxidant peptides synthesized by our engineered vessel cells. We hope to bring encouraging results in vitro to pave the way of this promising system into the lifesaving remedy method.

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