User:Yovaluflo

From 2014.igem.org

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<div class="subpanel1">
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    <div class="cont"><p style="font-size:32px;line-height:34px;">THE REPROGRAMMATOR PROJECT</p></div>
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    <div class="cont"><p style="font-size:32px;line-height:34px;">FIGHT TUBERCULOSIS WITH MODERN WEAPONS </p></div>
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In order to be capable of controlling transformed bacteria and reprogram its function as many times as would be required, we designed a system consisting of a bacteriophage that infects just one specific strain of bacteria and has on its genome the information to codify a <b>TALEN/ZFN</b> enzyme and a reporter gene. With this tools <b>(TALEN/ZFN)</b> we can target a specific sequence of the host's plasmids to degrade them. The bacteriophages will replace the plasmids, giving it a new function or characteristic that could be a totally new one.
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Tuberculosis (TB) is an infectious disease caused by <i>Mycobacterium tuberculosis</i> (Mtb) that affects nearly two billion people around the world. On this website we present four new ways to use the power of synthetic biology in the fight against TB: from gene detection, to drug targeting, to infiltrating macrophages, to sabotaging the synthesis of proteins. Hover over these panels to see the project overview.
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       <a href="https://2014.igem.org/Team:UANL_Mty-Mexico/Project/Results" title="Results">
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       <a href="https://2013.igem.org/Team:Paris_Bettencourt/Results" title="Results">
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  <img width="70px" style="margin-left:80px;margin-right:15px;position:relative;bottom:1px" src="https://static.igem.org/mediawiki/2013/d/d5/PB_handresults.gif"/>GO TO RESULTS
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  <img width="70px" style="margin-left:80px;margin-right:15px;position:relative;bottom:1px" src="https://static.igem.org/mediawiki/2013/d/d5/PB_handresults.gif"/>Jump to Results
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Revision as of 13:11, 14 October 2014

FIGHT TUBERCULOSIS WITH MODERN WEAPONS

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb) that affects nearly two billion people around the world. On this website we present four new ways to use the power of synthetic biology in the fight against TB: from gene detection, to drug targeting, to infiltrating macrophages, to sabotaging the synthesis of proteins. Hover over these panels to see the project overview.

A biosensor that detects the presence of sequence specific antibiotic resistance genes.

A safe and specific high-throughput drug screening method that targets essential mycobacterial metabolic proteins.

A phage system with low fitness cost producing sRNA, which inhibits the synthesis of antibiotic resistance proteins.

Infiltrate macrophages with an E.coli producing TDMH, an enzyme that will lyse the Mycobacteria cell wall.
Detect
Target
Infiltrate
Sabotage
Jump to Results
TB Facts
TB in France
TB Gallery
Gender Study
Technology Transfer

Team:Paris Bettencourt/footer

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