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Revision as of 13:09, 14 October 2014
Team:UANL Mty-Mexico/Wiki Team:UANL Mty-Mexico/Menu
THE REPROGRAMMATOR PROJECT
In order to be capable of controlling transformed bacteria and reprogram its function as many times as would be required, we designed a system consisting of a bacteriophage that infects just one specific strain of bacteria and has on its genome the information to codify a TALEN/ZFN enzyme and a reporter gene. With this tools (TALEN/ZFN) we can target a specific sequence of the host's plasmids to degrade them. The bacteriophages will replace the plasmids, giving it a new function or characteristic that could be a totally new one.
A biosensor that detects the presence of sequence specific antibiotic resistance genes.
A safe and specific high-throughput drug screening method that targets essential mycobacterial metabolic proteins.
A phage system with low fitness cost producing sRNA, which inhibits the synthesis of antibiotic resistance proteins.
Infiltrate macrophages with an E.coli producing TDMH, an enzyme that will lyse the Mycobacteria cell wall.
GO TO RESULTS
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