Intercellular Coordination Through Community Signaling

Cells in a local population have a wide range of responses to a given stimulus. This noisiness may be due to differences in extracelluar environment, or intracellular molecular makeup. Yet these cells often need to coordinate and respond in a concerted way. Our project seeks to understand the complex intercellular interactions that must happen to produce such a specific community phenotype.

Our goal is to create a synthetic framework that uses cellular communities to model collective behaviors emergent from individual autonomous rules.