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Team:TU Eindhoven/Modeling/Cell Encapsulation Modeling
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<h2>Cell Encapsulation Modeling</h2> | <h2>Cell Encapsulation Modeling</h2> | ||
| - | + | <p>The modeling group focused on the microfluidics. With microfluidics the cells are separated into a single droplet. This process however is not very accurate. Sometimes the droplets do not contain the desired number of cells. This can be modelled using a Poisson distribution. In this model you can define an average number of cells per droplet, lambda. Lambda was varied to choose a suitable average number of cells per droplet for our microfluidic device.</p> | |
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| - | <p>The modeling group focused on the microfluidics. With microfluidics the cells are separated into a single droplet. This process however is not very accurate. Sometimes the droplets do not contain the desired number of cells. This can be modelled using a Poisson distribution. In this model you can define an average number of cells per droplet, lambda. Lambda was varied to choose a suitable average number of cells per droplet for our microfluidic device.</p> | + | |
<img id='Fig1' src="https://static.igem.org/mediawiki/2014/f/fc/TU_Eindhoven_Modeling1.jpg" class="image_wrapper image_fr" width="1085"> | <img id='Fig1' src="https://static.igem.org/mediawiki/2014/f/fc/TU_Eindhoven_Modeling1.jpg" class="image_wrapper image_fr" width="1085"> | ||
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<img id='Fig3' src="https://static.igem.org/mediawiki/2014/3/33/TU_Eindhoven_Modeling3.jpg" class="image_wrapper image_fr" width="1085"> | <img id='Fig3' src="https://static.igem.org/mediawiki/2014/3/33/TU_Eindhoven_Modeling3.jpg" class="image_wrapper image_fr" width="1085"> | ||
<p style="font-size:18px;color:#CCCCCC;">Figure 3.</p> | <p style="font-size:18px;color:#CCCCCC;">Figure 3.</p> | ||
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| + | <h4>Bibliography</h4> | ||
| + | <p></p> | ||
</div> | </div> | ||
Revision as of 10:04, 11 October 2014
Cell Encapsulation Modeling
The modeling group focused on the microfluidics. With microfluidics the cells are separated into a single droplet. This process however is not very accurate. Sometimes the droplets do not contain the desired number of cells. This can be modelled using a Poisson distribution. In this model you can define an average number of cells per droplet, lambda. Lambda was varied to choose a suitable average number of cells per droplet for our microfluidic device.
Figure 1. Poisson distribution for multiple lambdas.
This allows for the determination of the ratios between one cell/zero cells and one cell/ two or more cells. These both have to be as high as possible for a specific lambda.
Figure 2. Ratio between one cell/ zero cells or more cells
Based on these results a lambda of 0.5 was chosen for the microfluidic device. The Poisson distribution for different number of cells becomes then as follows.
Figure 3.
