Team:Uppsala/Project Killing
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- | document.getElementById("tab1").innerHTML = '<img class="assembly_plan" src="https://static.igem.org/mediawiki/2014/2/25/Uppsala-igem2014Killingsystem.png"><h2>Bacteriocin</h2><p>With the growing problems of antibiotics we decided to use bacteriocincs as our antimicrobial. A bacteriocin is a peptide that is produced naturally by certain bacteria. It target close relatives to the producing bacteria. Unlike antibiotics the targets of bacteriocins are very specifc. The bacteriocin, colicin Fy is produced from y. frederiksenii and it will only target other yersinia species. Bacteriocins will either attack the cellmembrane or within the cell such as gene expression or protein production. One of colicins Fy main target is the y.enterocolitica. It kills y. enterocolitica by creating pores in its cellmembrane. Y. enterocolitica is also one of the more common pathogens in the gut and it causes some serious symptoms. That is why we choose colicin as the bacteriocin we want to express.</p>'; | + | document.getElementById("tab1").innerHTML = '<img class="assembly_plan" src="https://static.igem.org/mediawiki/2014/2/25/Uppsala-igem2014Killingsystem.png"><p>Figure 1. The assembly plan of the killing construct. The green arrow is the promotor, the red circle is the RBS and the yellow box is the gene which consist of an export tag, USP45 and the bacteriocin, colicin FyA fused together.</p><h2>Bacteriocin</h2><p>With the growing problems of antibiotics we decided to use bacteriocincs as our antimicrobial. A bacteriocin is a peptide that is produced naturally by certain bacteria. It target close relatives to the producing bacteria. Unlike antibiotics the targets of bacteriocins are very specifc. The bacteriocin, colicin Fy is produced from y. frederiksenii and it will only target other yersinia species. Bacteriocins will either attack the cellmembrane or within the cell such as gene expression or protein production. One of colicins Fy main target is the y.enterocolitica. It kills y. enterocolitica by creating pores in its cellmembrane. Y. enterocolitica is also one of the more common pathogens in the gut and it causes some serious symptoms. That is why we choose colicin as the bacteriocin we want to express.</p>'; |
Revision as of 16:19, 21 September 2014
Stephanie Herman
Teresa Reinli
Joakim Hellner
Alexander Virtanen
Jennifer Rosenius
Marcus Hong
Miranda Stiernborg
Tim Hagelby Edström
Viktor Blomkvist
Megha Biradar
Niklas Handin
Jonas Mattisson
Arina Gromov
Nils Anlind
Eric Sandström
Gunta Celma
Oliver Possnert
Martin Friberg
Kira Karlsson
Christoffer Andersson
Laura Pacoste
Andries Willem Boers
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