Project Description

With increasing antibiotic resistance in most of the pathogens, it becomes a critical problem to tackle in order to save the people of tomorrow. If we do not find an alternative to the antibiotics now, WHO estimates that the world will be thrown back to the hospital situation of the 1800’s.Considering this problem, the Uppsala iGEM team tries to combat it using the pathogen’s own quorum sensing system to help probiotic bacteria find and kill that specific pathogen. By acquiring the quorum sensing system from Yersinia enterocolitica, we can sense their presence and use it to control the movement and the expression of a specific bacteriocin in our probiotic. This bacteriocin produced will eliminate the Yersinia enterocolitica, leaving the gut flora intact.