Team:ULB-Brussels/Safety
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he main concerns raised by <i>Mighty Coli</i> depend more of the protein that we chose to produce than of <i>Mighty Coli</i> in itself. However, <i>Mighty Coli</i> could compel an escaped recombinant bacterium to produce an industrial protein in the environment, when a bacterium without the <i>Mighty Coli</i> system would quickly degenerate to stop producing the protein of industrial interest. The risk seems thin, since such an overproducing bacterium would suffer from a clear competitive disadvantage in a wild environment, but it is not excluded that the plasmid containing the <i>Mighty Coli</i> system maintains itself anyway through Horizontal Gene transfer (HGT), at the expend of the wild bacteria it infects, benefiting of the proprieties of the TA system.</p> | he main concerns raised by <i>Mighty Coli</i> depend more of the protein that we chose to produce than of <i>Mighty Coli</i> in itself. However, <i>Mighty Coli</i> could compel an escaped recombinant bacterium to produce an industrial protein in the environment, when a bacterium without the <i>Mighty Coli</i> system would quickly degenerate to stop producing the protein of industrial interest. The risk seems thin, since such an overproducing bacterium would suffer from a clear competitive disadvantage in a wild environment, but it is not excluded that the plasmid containing the <i>Mighty Coli</i> system maintains itself anyway through Horizontal Gene transfer (HGT), at the expend of the wild bacteria it infects, benefiting of the proprieties of the TA system.</p> | ||
Revision as of 07:11, 11 September 2014
$~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ \newcommand{\MyColi}{{\small Mighty\hspace{0.12cm}Coli}} \newcommand{\Stabi}{\small Stabi}$ $\newcommand{\EColi}{\small E.coli} \newcommand{\SCere}{\small S.cerevisae}\\[0cm] ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ \newcommand{\PI}{\small PI}$ $\newcommand{\Igo}{\Large\mathcal{I}} \newcommand{\Tgo}{\Large\mathcal{T}} \newcommand{\Ogo}{\Large\mathcal{O}} ~$
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