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Team:UIUC Illinois/Modeling
From 2014.igem.org
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| + | <center><p style="font-size: 400% ">Modeling</p></center> | ||
| + | <center><p style="font-size: 150% "><i>"The art of research [is] the art of making difficult problems soluble by devising means of getting at them. "</i></p></center> | ||
| + | <br><center>- Sir Peter Medawar</br></center> | ||
<h2>Mathematical Modeling of Caffeine Degradation Pathway</h2> | <h2>Mathematical Modeling of Caffeine Degradation Pathway</h2> | ||
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Revision as of 03:03, 18 October 2014
Modeling
"The art of research [is] the art of making difficult problems soluble by devising means of getting at them. "
Mathematical Modeling of Caffeine Degradation Pathway
Overview: To predict the result of bioreactor, we used mathematica to solve differential using Michaelis-Menton equation. The strength of utilizing mathematica rather than matlab was that it allowed us to set up the value of several constants as varying rather than setting it as invariant. Kcat & Km values were obtained through research papers by Swati & Sathyanarayana (2006), and Ryan M.Summers (2010).
This is caffeine demehtlyation pathway by demethlyase. It goes from Caffeine to theobromine to 7-methylxanthine to xanthine. The other pathway is caffeine dehydrogenase. It goes from Caffeine to Trimethyl Uric acid.
Parameters
| Name | Description |
|---|---|
| Vm | Maximum rate of system |
| Kcat | Maximum number of substrate molecules converted into products |
| Km | Substrate concentration where the reaction rate is half of maximum (depend on both enzyme and substrate) |
Fig1. Caffeine Demethylation Pathway
Fig2. Caffeine Dehydrogenase Pathway
Modeling Dog's intestine
Description:
Fig3. Dog's Intestine & Blood Model
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