Team:Georgia State

From 2014.igem.org

(Difference between revisions)
Line 204: Line 204:
                             <div class="service-content">
                             <div class="service-content">
                                 <h4>Mambalgin Synthesis</h4>
                                 <h4>Mambalgin Synthesis</h4>
-
                                 <p><img src="" width="320" height="240" /></p>
+
                                 <p><img src="https://static.igem.org/mediawiki/2014/5/5d/Step3.gif" width="320" height="240" /></p>
                                 <p><a href="https://2014.igem.org/Team:Georgia_State/Project_Summary/">Read more...</a></p>
                                 <p><a href="https://2014.igem.org/Team:Georgia_State/Project_Summary/">Read more...</a></p>
                             </div>
                             </div>
Line 219: Line 219:
                             <div class="service-content">
                             <div class="service-content">
                                 <h4>The Applications</h4>
                                 <h4>The Applications</h4>
-
                                 <p>Our research is far reaching and has the potential to completely transform the medical industry with non-addictive pain management.</p>
+
                                 <p>Mambalgin binds to the Acid Sensing Ion Channel (ASIC) in order to block pain signals. Mambalgin is as effective as opiate pain killers but is non-addictive.</p>
                                 <p><a href="https://2014.igem.org/Team:Georgia_State/Project_Summary/">Read more...</a></p>
                                 <p><a href="https://2014.igem.org/Team:Georgia_State/Project_Summary/">Read more...</a></p>
                             </div>
                             </div>

Revision as of 23:58, 17 October 2014

Mamba | Georgia State University

  • slidebg1
    A Solution
    that we need!
    This is a subheadline text sentence
    Sed ut perspiciatis unde omnis iste natus error sit voluptatem
    accusantium doloremque laudantium, totam rem aperiam.
    Button Text
  • slidebg1
    A Solution
    that we need!
    This is a subheadline text sentence
    Sed ut perspiciatis unde omnis iste natus error sit voluptatem
    accusantium doloremque laudantium, totam rem aperiam.
    Button Text

Building an Expression Vector

Read more...

Transforming Linearized Mambalgin into P. pastoris

Read more...

Mambalgin Synthesis

Read more...

The Applications

Mambalgin binds to the Acid Sensing Ion Channel (ASIC) in order to block pain signals. Mambalgin is as effective as opiate pain killers but is non-addictive.

Read more...

Mamba: An entry into iGEM 2014

Our team from Georgia State University has been working to successfully insert and purify mambalgin, a protein component of the venom of Dendroaspis Polylepis, better known as the Black Mamba. The mambalgin peptide is a powerful analgesic that directly blocks pain transmission in the peripheral nervous system (Diochot et al, 2012) by targeting acid sensing ion channels within nociceptors beneath the epidermis. Furthermore, recombinant purification of mambalgin could assist in developing anti-venom without the attendant risk of harvesting venom directly from snakes.

Read More

From the Lab

Video Highlights

Partners & Sponsors

Retrieved from "http://2014.igem.org/Team:Georgia_State"