Team:Paris Bettencourt

From 2014.igem.org

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<div id=sweat><a class=layout href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Eliminate_Smell"><p class=descript2>Bacteria processing sweat is the primary cause of body odor. Our project aims to study the bacteria involved in the creation of malodorant compounds and try to find natural variant that are odorless. The final goal would be to create a probiotic cosmetic. </p></a></div>
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<div id=sweat><a class=layout href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Eliminate_Smell"><p class=descript2>Armpit odor comes mainly from aminoacylase enzymes expressed in the genus Corynebacteria. This project is developing CRISPR technology to isolate natural bacterial mutants that lack these enzymes.</p></a></div>
<a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Eliminate_Smell"><img src="https://static.igem.org/mediawiki/2014/e/e1/Dontsweatit.png" class=nameimg></a>
<a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Eliminate_Smell"><img src="https://static.igem.org/mediawiki/2014/e/e1/Dontsweatit.png" class=nameimg></a>
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<div id=smell><a class=layout href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Odor_Library"><p class=descript2>Here we present the design of an odour palette. It is composed of BioBricks containing coding sequences for different enzymes known to catalyse reactions that yield volatile compounds with characteristic smells. We included smells with different tonalities such in order to explore the resulting aromas from different combinations of smelly units. </p></a></div>
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<div id=smell><a class=layout href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Odor_Library"><p class=descript2>Here we present a genetic odor palette. It is built of BioBricks to express enzymes to produce volatile compounds with characteristic smells. We included smells with different tonalities to allow exploration of the "odor space" resulting from combinations of smelly units.</p></a></div>
<a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Odor_Library"><img src="https://static.igem.org/mediawiki/2014/b/b1/Smelltheroses.png" class=nameimg></a>
<a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Odor_Library"><img src="https://static.igem.org/mediawiki/2014/b/b1/Smelltheroses.png" class=nameimg></a>
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<div id=teen><a class=layout href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Old_People_Smell"><p class=descript2>2-nonenal is a compound, with very specific strong odor perceived as iris, fat, and cucumber, which rate increases with age. Our goal is to study relationship between human skin bacteria and 2-nonenal.</p></a></div>
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<div id=teen><a class=layout href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Old_People_Smell"><p class=descript2>2-nonenal is "old people smell," a component of sweat that increases with age. Here we isolate and characterize bacterial species that metabolize 2-nonenal and attenuate its characteristic odor.</p></a></div>
<a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Old_People_Smell"><img src="https://static.igem.org/mediawiki/2014/6/6f/Teenspirit.png" class=nameimgts></a>
<a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Old_People_Smell"><img src="https://static.igem.org/mediawiki/2014/6/6f/Teenspirit.png" class=nameimgts></a>
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<div id=fish><a class=layout href="https://2014.igem.org/Team:Paris_Bettencourt/Project/TMAU"><p class=descript2>Trimethylaminuria (TMAU) is a rare genetic disease causing a strong fish odor. Our project aims at engineering skin bacteria to degrade trimethylamine, the odor causing molecule, by the enzyme TMM (trimethylamine monooxygenase).</p></a></div>
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<div id=fish><a class=layout href="https://2014.igem.org/Team:Paris_Bettencourt/Project/TMAU"><p class=descript2>Trimethylaminuria (TMAU) is a rare genetic disease causing a strong fish odor to appear in the sweat. Here we engineer skin bacteria to degrade trimethylamine, the odor causing molecule, with the enzyme TMM (trimethylamine monooxygenase).</p></a></div>
<a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/TMAU"><img src="https://static.igem.org/mediawiki/2014/b/b9/Somethingfishy.png" class=nameimgsf></a>
<a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/TMAU"><img src="https://static.igem.org/mediawiki/2014/b/b9/Somethingfishy.png" class=nameimgsf></a>
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<div id=shoes><a class=layout href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Foot_Odor"><p class=descript2>Isovaleric acid is a compound produced by B. subtilis through leucine
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<div id=shoes><a class=layout href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Foot_Odor"><p class=descript2>Isovaleric acid, the cheesy component of foot odor, is produced by B. subtilis through the leucine degradation pathway. We characterize B. subtilis mutants in this pathway, in vitro and in situ (on socks).</p></a></div>
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degradation pathway, which is hypothesized to be responsible for the
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foot odor (cheese smell.) Our project aims at validating this
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hypothesis with the aid of both invitro and insitu experimentation's.</p></a></div>
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<a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Foot_Odor"><img src="https://static.igem.org/mediawiki/2014/3/3a/Goodytwoshoes.png" class=nameimg></a>
<a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Foot_Odor"><img src="https://static.igem.org/mediawiki/2014/3/3a/Goodytwoshoes.png" class=nameimg></a>

Revision as of 08:32, 17 October 2014


Body odor is caused by the metabolic action of bacteria on human sweat. Existing deodorants are antibiotic - they kill all skin bacteria including neutral and beneficial species. Where body odor carries a social stigma, alternatives to deodorant are few.

The iGEM Paris Bettencourt 2014 project explores new ways to control body odors through precise modifications of the living microbiome. We target common odors of the armpit and foot, as well as odors specific to old age or genetic disease. We present a BioBrick smell library for mixing genetic perfumes and a CRISPR-mediated technology for isolating naturally odorless bacterial strains.

Our work represents a probiotic and body-positive approach to body odor that will someday help people to smell just like themselves.

Centre for Research and Interdisciplinarity (CRI)
Faculty of Medicine Cochin Port-Royal, South wing, 2nd floor
Paris Descartes University
24, rue du Faubourg Saint Jacques
75014 Paris, France
+33 1 44 41 25 22/25
paris-bettencourt-igem@googlegroups.com
Copyright (c) 2014 igem.org. All rights reserved.

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