Team:MIT

From 2014.igem.org

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<td width=33.3%><img src="https://static.igem.org/mediawiki/2014/6/6b/MIT_homepage_dying_neuron.png"><br>Neurodegenerative Disease</td>
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<td width=33.3%><img src="https://static.igem.org/mediawiki/2014/6/6b/MIT_homepage_dying_neuron.png"></td>
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<td width=33.3%><img src="https://static.igem.org/mediawiki/2014/e/e4/MIT_homepage_sixth.png"><br>Leading cause of death in the US</td>
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<td width=33.3%><img src="https://static.igem.org/mediawiki/2014/e/e4/MIT_homepage_sixth.png"></td>
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<td width=33.3%><img src="https://static.igem.org/mediawiki/2014/4/44/MIT_hompage_vaccine.png"><br>Current diagnosis and therapeutics are not effective</td>
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<td width=33.3%><img src="https://static.igem.org/mediawiki/2014/4/44/MIT_hompage_vaccine.png"></td>
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<td width=33.3%><p style="font-size:15px; color:black" align=top> Neurodegenerative disease</p></td>
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<td width=33.3%><p style="font-size:15px; color:black"> Sixth leading cause of death in the US</p></td>
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<td width=33.3%><p style="font-size:15px; color:black"> Current diagnostics and therapeutics <br> are ineffective</p></td>
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Revision as of 21:11, 16 October 2014

 


Image Map



Improving the Diagnosis and Treatment of

ALZHEIMER'S DISEASE


Neurodegenerative disease

Sixth leading cause of death in the US

Current diagnostics and therapeutics
are ineffective

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by memory loss, behavioral problems… There is currently no cure for this disease, and existing diagnosis methods leave much to be desired. MIT iGEM 2014 has set out to change this. By detecting molecular biomarkers for AD, such as miRNAs and neurotoxic beta-amyloid plaques, and by regulating the production of beta-amyloid plaques, MIT iGEM hopes to create a dynamic solution for patients with Alzheimer’s disease. Looking ahead, … delivery.


DETECTION → TREATMENT → DELIVERY


DETECTION


Native beta-amyloid receptor


Engineered B-cell receptor


miRNA sensors for Alzheimer’s state


TREATMENT

DELIVERY

Regulating beta-amyloid production
and degradation

Delivering our circuit