Team:MIT

From 2014.igem.org

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<td width=33.3%>[Dying Neuron]<br>Neurodegenerative Disease</td>
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Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by memory loss, behavioral problems…  There is currently no cure for this disease, and existing diagnosis methods leave much to be desired.  MIT iGEM 2014 has set out to change this.  By detecting molecular biomarkers for AD, such as miRNAs and neurotoxic beta-amyloid plaques, and by regulating the production of beta-amyloid plaques, MIT iGEM hopes to create a dynamic solution for patients with Alzheimer’s disease.  Looking ahead, … delivery.<br>
 
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DETECT → TREAT → DELIVER
 
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<tr><td><p align=left>Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by memory loss, behavioral problems…  There is currently no cure for this disease, and existing diagnosis methods leave much to be desired.  MIT iGEM 2014 has set out to change this.  By detecting molecular biomarkers for AD, such as miRNAs and neurotoxic beta-amyloid plaques, and by regulating the production of beta-amyloid plaques, MIT iGEM hopes to create a dynamic solution for patients with Alzheimer’s disease.  Looking ahead, … delivery.<br>
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DETECT → TREAT → DELIVER</p></tr></td>
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Revision as of 06:15, 15 October 2014

 


Image Map


[Dying Neuron]
Neurodegenerative Disease
[6th]
Leading cause of death in the US
[Vaccine]
Current diagnosis and therapeutics are not effective

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by memory loss, behavioral problems… There is currently no cure for this disease, and existing diagnosis methods leave much to be desired. MIT iGEM 2014 has set out to change this. By detecting molecular biomarkers for AD, such as miRNAs and neurotoxic beta-amyloid plaques, and by regulating the production of beta-amyloid plaques, MIT iGEM hopes to create a dynamic solution for patients with Alzheimer’s disease. Looking ahead, … delivery.
DETECT → TREAT → DELIVER

DETECTION


Natural AB receptor

Engineered AB receptor

Sensors for Alzheimer’s state

TREATMENT

DELIVERY

Regulate AB production
and degradation
Ways to deliver our circuit