Team:MIT

From 2014.igem.org

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Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by memory loss, behavioral problems…  There is currently no cure for this disease, and existing diagnosis methods leave much to be desired.  MIT iGEM 2014 has set out to change this.  By detecting molecular biomarkers for AD, such as miRNAs and neurotoxic beta-amyloid plaques, and by regulating the production of beta-amyloid plaques, MIT iGEM hopes to create a dynamic solution for patients with Alzheimer’s disease.  Looking ahead, … delivery.<br>
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by memory loss, behavioral problems…  There is currently no cure for this disease, and existing diagnosis methods leave much to be desired.  MIT iGEM 2014 has set out to change this.  By detecting molecular biomarkers for AD, such as miRNAs and neurotoxic beta-amyloid plaques, and by regulating the production of beta-amyloid plaques, MIT iGEM hopes to create a dynamic solution for patients with Alzheimer’s disease.  Looking ahead, … delivery.<br>
DETECT → TREAT → DELIVER
DETECT → TREAT → DELIVER
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<table width=100%>
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<tr><td colspan=3>Detection</td>
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<table width=95% align=center>
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<tr><td colspan=3><h3>DETECTION</h3></td>
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</tr>
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</table>
</table>
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TREATMENT<br>
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</table>
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<img src="https://static.igem.org/mediawiki/2014/1/19/MIT_treatment_homepage.png"><br>
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Regulate AB production<br>
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<table width=75% align=center>
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and degredation<br>
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<tr><td><h3>TREATMENT</h3></td>
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<table width=100%>
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<td><h3>DELIVERY</h3></td>
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<tr><td colspan=2>Future</td>
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</tr>
</tr>
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<td width=50%><img src="https://static.igem.org/mediawiki/2014/1/19/MIT_treatment_homepage.png"><br>Regulate AB production<br>
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and degredation<br></td>
<td width=50%><img src="https://static.igem.org/mediawiki/2014/0/06/MIT_future_homepage.png"><br>Ways to deliver our circuit</td>
<td width=50%><img src="https://static.igem.org/mediawiki/2014/0/06/MIT_future_homepage.png"><br>Ways to deliver our circuit</td>
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<td width=50%>[Survey]<br>Public Opinion Survey</td>
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</table>
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Revision as of 06:07, 15 October 2014

 


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[Dying Neuron]
Neurodegenerative Disease		 [6th]
Leading cause of death in the US		 [Vaccine]
Current diagnosis and therapeutics are not effective
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by memory loss, behavioral problems… There is currently no cure for this disease, and existing diagnosis methods leave much to be desired. MIT iGEM 2014 has set out to change this. By detecting molecular biomarkers for AD, such as miRNAs and neurotoxic beta-amyloid plaques, and by regulating the production of beta-amyloid plaques, MIT iGEM hopes to create a dynamic solution for patients with Alzheimer’s disease. Looking ahead, … delivery.
DETECT → TREAT → DELIVER

DETECTION

Natural AB receptor
Engineered AB receptor
Sensors for Alzheimer’s state

TREATMENT

DELIVERY

Regulate AB production
and degredation
Ways to deliver our circuit

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