Team:UT-Tokyo/CTCD/Content

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<p>EpCAM is a trans membrane glycoprotein which is expressed in epithelial cells and shows high level expression in various type of human epithelial carcinomas[2].Using this promoter, reporter genes can be expressed only in cancer cells.</p>
<p>EpCAM is a trans membrane glycoprotein which is expressed in epithelial cells and shows high level expression in various type of human epithelial carcinomas[2].Using this promoter, reporter genes can be expressed only in cancer cells.</p>
<h3>miRNA-142</h3>
<h3>miRNA-142</h3>
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<p>MiRNA is a class of non-coding RNA.MiRNA binds the miRNA-recognition element in the 3' untranslated region of the target gene. MiRNA shows the tissue-specific expression pattern. In our project, we use miRNA-142, which is expressed only in hematopoietic cells[3].Adding the recognition element of miRNA-142 in the 3' untranslated region of the reporter genes, leaky expression in non-carcinoma hematopoietic cells can be reduced.</p> </div>
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<p>MiRNA is a class of non-coding RNA.MiRNA binds the miRNA-recognition element in the 3' untranslated region of the target gene. MiRNA shows the tissue-specific expression pattern. In our project, we use miRNA-142, which is expressed only in hematopoietic cells[3].Adding the recognition element of miRNA-142 in the 3' untranslated region of the reporter genes, leaky expression in non-carcinoma hematopoietic cells can be reduced.</p>
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<img src="https://static.igem.org/mediawiki/2014/6/64/Kobari_pegp2.png" class = "figure" />
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<img src="https://static.igem.org/mediawiki/2014/4/44/Kobari_hematopoietic_cell.png" class = "figure" />
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<img src="https://static.igem.org/mediawiki/2014/9/94/Kobari_CTC.png" class = "figure" />
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</div>
<!-- Project application -->
<!-- Project application -->
<div id = "Project-2">
<div id = "Project-2">

Revision as of 05:51, 12 October 2014

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