Revision as of 14:04, 3 October 2014

Home

Failed to load tracking. JS is probably not enabled

Back to Top

@@ Line 3: / Line 3: @@
 <script>
-document.getElementById("tab1").innerHTML = '<h2>Background</h2><p>To facilitate the understanding of our multi-part system, a simulation for cell-cell interaction was coded in Java. Realistic data on movement and reproduction were applied so that our new introduced functions could be evaluated in this environment.  This resulted in a two dimensional program where bacteria can interact with each other in real time, as if looked at in a microscope. By emitting signals, bacteria can change movement pattern of, or kill, other species in their vicinity. The program can be easily changed and applied to similar systems, hopefully making it a useful tool for understanding and evaluating future projects as well. <br><br>The new function we invoke in our host-bacteria includes many different parts. Since it might be difficult to grasp how they will work as a unit we decided to make an intuitive simulation on micro level to visualize this. In this scenario we consider our probiotic moving around on the small intestinal wall and reaching the outer surface of a Yersinia enterocolitica colony. By inferring data on movement and duplication as well as our introduced features we can simulate a realistic model of how our bacteria would act, if looked at in a microscope, in real time. This also gives us a measure of how effective our introduced systems will be and add insight to how the systems can be improved. In the simulation you are, for example, given the option to remove the Targeting system to see how it affects our main purpose.</p><ul class="reference"><li>[1]Aswathy Sreedharan, C.J., 2012. Preventing Foodborne Illness: Yersiniosis [WWW Document]. URL http://edis.ifas.ufl.edu/fs193 (accessed 8.24.14).</li><li>[2]De Berardis, B., Torresini, G., Brucchi, M., Marinelli, S., Mattucci, S., Schietroma, M., Vecchio, L., Carlei, F., 2004. Yersinia enterocolitica intestinal infection with ileum perforation: report of a clinical observation. Acta Biomed 75, 77–81.</li><li>[3]77–81. H. C. Berg, 2004. E. coli in motion. Biological and medical physics series.	(Springer, NewYork)</li><li>[4]Schwartz, S.A., Helinski, D.R., 1971. Purification and characterization of colicin E1. J. Biol. Chem. 246, 6318–6327.</li><li>[5]Spangler, R., Zhang, S.P., Krueger, J., Zubay, G., 1985. Colicin synthesis and cell death. J Bacteriol 163, 167–173.</li></ul></p><ul class="launchlist"><li><a href="#" id="launchDemo"> Launch </a></li><li><a href="#" id="downloadDemo">Download</a></li></ul>';
+document.getElementById("tab1").innerHTML = '<h2>Introduction</h2><p>To facilitate the understanding of our multi-part system, a simulation for cell-cell interaction was coded in Java. Realistic data on movement and reproduction were applied so that our new introduced functions could be evaluated in this environment.  This resulted in a two dimensional program where bacteria can interact with each other in real time, as if looked at in a microscope. By emitting signals, bacteria can change movement pattern of, or kill, other species in their vicinity. The program can be easily changed and applied to similar systems, hopefully making it a useful tool for understanding and evaluating future projects as well. <br><br>The new function we invoke in our host-bacteria includes many different parts. Since it might be difficult to grasp how they will work as a unit we decided to make an intuitive simulation on micro level to visualize this. In this scenario we consider our probiotic moving around on the small intestinal wall and reaching the outer surface of a Yersinia enterocolitica colony. By inferring data on movement and duplication as well as our introduced features we can simulate a realistic model of how our bacteria would act, if looked at in a microscope, in real time. This also gives us a measure of how effective our introduced systems will be and add insight to how the systems can be improved. In the simulation you are, for example, given the option to remove the Targeting system to see how it affects our main purpose.<h2>Why Java?<2</p><ul class="reference"><li>[1]Aswathy Sreedharan, C.J., 2012. Preventing Foodborne Illness: Yersiniosis [WWW Document]. URL http://edis.ifas.ufl.edu/fs193 (accessed 8.24.14).</li><li>[2]De Berardis, B., Torresini, G., Brucchi, M., Marinelli, S., Mattucci, S., Schietroma, M., Vecchio, L., Carlei, F., 2004. Yersinia enterocolitica intestinal infection with ileum perforation: report of a clinical observation. Acta Biomed 75, 77–81.</li><li>[3]77–81. H. C. Berg, 2004. E. coli in motion. Biological and medical physics series.	(Springer, NewYork)</li><li>[4]Schwartz, S.A., Helinski, D.R., 1971. Purification and characterization of colicin E1. J. Biol. Chem. 246, 6318–6327.</li><li>[5]Spangler, R., Zhang, S.P., Krueger, J., Zubay, G., 1985. Colicin synthesis and cell death. J Bacteriol 163, 167–173.</li></ul></p><ul class="launchlist"><li><a href="#" id="launchDemo"> Launch </a></li><li><a href="#" id="downloadDemo">Download</a></li></ul>';
 document.getElementById("tab2").innerHTML = '<p>Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat.Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat.</p>';

Team:Uppsala/Modeling CellCellInteraction

From 2014.igem.org

Revision as of 14:04, 3 October 2014

Home