"
Team:UT-Tokyo
From 2014.igem.org
Pineappler (Talk | contribs) |
Pineappler (Talk | contribs) |
||
| Line 23: | Line 23: | ||
<div id = "index-body"> | <div id = "index-body"> | ||
<div class = "content-box"> | <div class = "content-box"> | ||
| - | <h2>Project Description</h2> | + | <h2>Project Description</h2> |
| - | <p>In the field of synthetic biology, Genetic memory devices have been constructed and applied widely from Biocomputing to biomedical technologies as a crucial component. Such memory devices include a cellular counter; a fundamental device which memorizes the number of induction events. Recent efforts have resulted in a cellular counter that can count up to three events. However, this counter cannot be reset to its initial state. Here, we propose a resettable cellular counter called “sigma recounter”. This counter utilizes the regulation system of sigma factor and anti-sigma factor as the key of its resetting mechanism. In this system a set of sigma factors are designed to update and maintain a count that responds to each inducted event. By the other stimulus, the system initiates a genetic circuit that can express a suitable set of anti-sigma factors and erases the existing memory, which will enable our device to restart the count from any state.</p> | + | <p>In the field of synthetic biology, Genetic memory devices have been constructed and applied widely from Biocomputing to biomedical technologies as a crucial component. Such memory devices include a cellular counter; a fundamental device which memorizes the number of induction events. Recent efforts have resulted in a cellular counter that can count up to three events. However, this counter cannot be reset to its initial state. Here, we propose a resettable cellular counter called “sigma recounter”. This counter utilizes the regulation system of sigma factor and anti-sigma factor as the key of its resetting mechanism. In this system a set of sigma factors are designed to update and maintain a count that responds to each inducted event. By the other stimulus, the system initiates a genetic circuit that can express a suitable set of anti-sigma factors and erases the existing memory, which will enable our device to restart the count from any state.</p> |
| + | </div> | ||
| + | <div class = "content-box"> | ||
| + | <div id = "box-left"> | ||
| + | <h2>Our Team</h2> | ||
| + | </div> | ||
| + | <div id = "box-right"> | ||
| + | <h2>Address</h2> | ||
| + | </div> | ||
</div> | </div> | ||
</div> | </div> | ||
</body> | </body> | ||
</html> | </html> | ||
Revision as of 13:29, 13 September 2014
Project Description
In the field of synthetic biology, Genetic memory devices have been constructed and applied widely from Biocomputing to biomedical technologies as a crucial component. Such memory devices include a cellular counter; a fundamental device which memorizes the number of induction events. Recent efforts have resulted in a cellular counter that can count up to three events. However, this counter cannot be reset to its initial state. Here, we propose a resettable cellular counter called “sigma recounter”. This counter utilizes the regulation system of sigma factor and anti-sigma factor as the key of its resetting mechanism. In this system a set of sigma factors are designed to update and maintain a count that responds to each inducted event. By the other stimulus, the system initiates a genetic circuit that can express a suitable set of anti-sigma factors and erases the existing memory, which will enable our device to restart the count from any state.
