Team:KAIT JAPAN

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'''[[Team:KAIT_Japan/Project|Project]]:<span style="color:#f33">Abstract'''</span>
'''[[Team:KAIT_Japan/Project|Project]]:<span style="color:#f33">Abstract'''</span>
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:<big>Hay fever curE.coli ~revenge~</big>
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<font size="4">~Cure allergy system~</font>
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Acquired immune system is one of two main immunity strategies in vertebrates.
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:I looked back at the failure of last year. I think it tries to complete this plan this year. Japanese on of six people is troubled now by hay fever. These people take a medicine for its. But, If they take it , they become sleepy. So we are working on a project to relive hay fever by E.Coli to improve these. Mechanism of hay fever When an allergen invades it in the living body, naïve T cell differentiates in Th2. There is more Th2 than Th1, and the mast cell and others that is humoral immunity become active, and inflammation is in this way caused. We perform following four this time. ①Expression of IL-10 receptor to E.coli. ②Phosphorylation of STAT3. ③Preparation of gene array with HlyA and L-12 promoter and receiving the STAT3. ④Preparation of gene array with TolC and HlyB and HlyD promoter and to receive the STAT3. 
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In this system , Helper T cells work mainly.
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Th1 cells and Tｈ2 cells keep balance mutually, and two cells usually control immune response. When this balance collapses and became the Th2 predominance, IL-5 is secreted excessively from Th2, and eosonophil,basophil,and mast cells are activated by IL-5. These activated cells secrete inflammatory materials that cause allergic symptoms such as bronchial asthma and atopic dermatitis. On the other hand, by stimulation of IL-12, naïve T cell differentiates into Th1 cell and Th1 cell alleviates allergic symptoms. We though it is possible to ameliorate allergic symptoms by decreasing IL-5 and increasing IL-12. Focusing on ligand dependent dimerization of IL-5 receptor ,we try to make IL5 independent expression system .
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::1. Expression of IL-10 receptor to E.coli.
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::2. Phosphorylation of STAT3.
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::3. Preparation of gene array with HlyA and L-12 promoter and receiving the STAT3.
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::4. Preparation of gene array with TolC and HlyB and HlyD promoter and to receive the STAT3. 
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Latest revision as of 14:54, 16 October 2014

ロゴ2.png

KAIT Japan2013 Kanako.png

KAIT Japan 2014 iGEMRogo.png
New home t.jpg

Home

New Team1.jpg

Team

New 考える人.jpg

Project

New 歯車.jpg

Parts

New １１１１１１１１１１１１１１１.jpg

Protocol

Ff.jpg

Notebook

New 結果.jpg

Results

New new 危険.jpg

Safety

New new ひと.jpg

Human Practice

KAIT_Japan-photo-side.jpg
Welcome to KAIT JAPAN !

Our team started a new project !
The details are Project page.

News

9/1 Team OPEN!
9/1 Safety OPEN!
8/25 Protocol OPEN!
8/25 Notebook OPEN!

Contacts

KAIT Japan Twi.png ‎[http://twitter.com/KAIT_JAPAN @KAIT_JAPAN]
KAIT Japan Face.png [http://www.facebook.com/KAIT.Japan KAIT Japan]
[http://sites.google.com/site/kaitjapan/ KAIT Japan(Japanese)] KAIT Japan info.png
KAIT Japan

Sponsors

KAIT Japan 2014 Yume.png


KAIT Japan 2014 Cosmo.png

KAIT_Japan2013_Achoo%21.png

Project:Abstract
~Cure allergy system~

Acquired immune system is one of two main immunity strategies in vertebrates. In this system , Helper T cells work mainly. Th1 cells and Tｈ2 cells keep balance mutually, and two cells usually control immune response. When this balance collapses and became the Th2 predominance, IL-5 is secreted excessively from Th2, and eosonophil,basophil,and mast cells are activated by IL-5. These activated cells secrete inflammatory materials that cause allergic symptoms such as bronchial asthma and atopic dermatitis. On the other hand, by stimulation of IL-12, naïve T cell differentiates into Th1 cell and Th1 cell alleviates allergic symptoms. We though it is possible to ameliorate allergic symptoms by decreasing IL-5 and increasing IL-12. Focusing on ligand dependent dimerization of IL-5 receptor ,we try to make IL5 independent expression system .

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