Team:Penn

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<title>Penn iGEM Wiki 2014</title>
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<title>University of Pennsylvania iGEM</title>
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<video width="600" controls poster="https://static.igem.org/mediawiki/2014/5/55/Penn_2014_logo.png"><source src="https://static.igem.org/mediawiki/2014/a/a5/Penn_2014_team_introduction.mp4" type="video/mp4" />
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<td style = "width:250;"><a href="https://2014.igem.org/Team:Penn/Microbio"><img id = "menuicon" src="https://static.igem.org/mediawiki/2014/d/df/Magnetic_bacteria_graphic.png"></a></td>
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<td style = "width:250;"><a href="https://2014.igem.org/Team:Penn/Synbio"><img id = "menuicon" src="https://static.igem.org/mediawiki/2014/6/6e/Penn_2014_wiki_2.png"></a></td>
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<td style = "width:250;"><a href="https://2014.igem.org/Team:Penn/CdTolerance"><img id = "menuicon" src="https://static.igem.org/mediawiki/2014/9/9e/Penn_2014_wiki_3.png"></a></td>
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<td style = "text-align: center;"><a href="https://2014.igem.org/Team:Penn/Microbio">Microbiology in AMB-1</a></td>
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<td style = "text-align: center;"><a href="https://2014.igem.org/Team:Penn/Microbio/Synbio">Synthetic Biology in AMB-1</a></td>
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<td style = "text-align: center;"><a href="https://2014.igem.org/Team:Penn/CdTolerance">Cadmium Tolerance in E. Coli vs. AMB-1</a></td>
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<td style = "width:250;" ><a href="https://2014.igem.org/Team:Penn/Magnetism"><img id = "menuicon" src="https://static.igem.org/mediawiki/2014/8/86/Penn_2014_wiki_4.png"></a></td>
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<td style = "width:250;"><a href="https://2014.igem.org/Team:Penn/Specsheet"><img id = "menuicon" src="https://static.igem.org/mediawiki/2014/5/50/Penn_2014_wiki_5.png"></a></td>
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<td style = "width:250;"><a href="https://2014.igem.org/Team:Penn/Outreach"><img id = "menuicon" src="https://static.igem.org/mediawiki/2014/b/bb/Penn_2014_wiki_6.png"></a></td>
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<td style = "text-align: center;"><a href="https://2014.igem.org/Team:Penn/Magnetism">Magnetism of AMB-1</a></td>
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<td style = "text-align: center;"><a href="https://2014.igem.org/Team:Penn/Specsheet">Spec Sheet</a></td>
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<td style = "text-align: center;"><a href="https://2014.igem.org/Team:Penn/Outreach">Human Practices</a></td>
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<a href="https://2014.igem.org/Team:Penn/Overview"><img width="80px" src="https://static.igem.org/mediawiki/2014/thumb/archive/c/ca/20141018025849%21Syn-bio-amb-1-flow-arrow.png/120px-Syn-bio-amb-1-flow-arrow.png">;
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<p><a href="http://www.upenn.edu">University of Pennsylvania</a> <span>iGEM 2014</span></p>
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<li><a href="https://2014.igem.org/Team:Penn"><span class="menu_item">Home</span></a></li>
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    <li>|</li>
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<li><a href="https://2014.igem.org/Team:Penn/Project" ><span class="menu_item">Project</span></a>
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<li><a href="https://2014.igem.org/Team:Penn/Overview">Overview</a></li>
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<li><a href="https://2014.igem.org/Team:Penn/Motivation">Motivation</a></li>
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            <li><a href="https://2014.igem.org/Team:Penn/Notebook">Notebook</a></li>
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<li><a href="https://2014.igem.org/Team:Penn/HumanPractices"><span class="menu_item">Human Practices</span></a></li>
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<li><a href="https://2014.igem.org/Team:Penn/us"><span class="menu_item">About us</span></a>
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<li><a href="https://2014.igem.org/Team:Penn/Team">Team</a></li>
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<li><a href="https://2014.igem.org/Team:Penn/Sponsors">Sponsors</a></li>
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    <div id="igem_logo"><a href="https://igem.org/Main_Page"> <img src="https://static.igem.org/mediawiki/igem.org/6/60/Igemlogo_300px.png" width="50px"></a>
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    <iframe id="center_video" src="http://www.youtube.com/embed/YtDIXSmUrV8" frameborder="0" allowfullscreen></iframe>
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<div id="abstract">
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<h1>Abstract</h1>
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Exposure to cadmium, a heavy metal commonly used in industrial processes, causes serious health problems including kidney disease, lung damage, bone fragility, cancer, infertility, and death. There is significant demand for the effective bioremediation of cadmium in developing countries and in industrial regions. Current methods are expensive and often produce undesired byproducts. This project aims to engineer a strain of magnetotactic bacteria known as Magnetospirillum magneticum AMB-1 for biosorption of cadmium. <br>
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AMB-1 is a strain of magnetotactic bacteria that aligns to magnetic fields with magnetite-accumulating organelles. This strain has been identified as a suitable chassis as it can be isolated with magnetic forces and may carry a heavy metal transporter that could result in natural cadmium tolerance. A metal transporter gene native to magnetotactic strains (mntH) and a S-adenosyl-methionine-dependent methyltransferase (smtA) derived from E. coli were incorporated into a genetic circuit designed to maximize biosorption and cadmium tolerance. AMB-1 carrying this design on a shuttle vector plasmid was tested for bioremediation efficiency.
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Latest revision as of 04:00, 18 October 2014

University of Pennsylvania iGEM

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Retrieved from "http://2014.igem.org/Team:Penn"