Team:Lethbridge

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=<font color="black">Project Summary=
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<tr><td colspan="3"> Every year, traumatic brain injury, stroke and neurodegenerative disease collectively cost the Canadian medical system millions of dollars while effective neural regenerative therapies remain elusive. Astrogliosis, a cellular response common to such neural insults, leads to the formation of a non-functional “glial scar” and an inhibitory cellular environment that impedes neural regeneration and further recovery. Our proposed project involves engineering microglia, the mobile immune cells of the brain, to package and deliver a therapeutic plasmid DNA construct specifically to the reactive astrocytes that comprise these glial scars. The plasmids will contain a reprogramming factor that converts reactive astrocytes into new neurons, helping to both restore the functional neuronal population and permit regrowth of damaged connections. Altogether, this study provides the basis for a novel, tissue-specific, personalized, non-immunogenic, non-invasive neural rehabilitative therapy that has the potential to significantly improve current methods of stimulating functional recovery following brain injury or disease onset. </td></tr>
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<br><b style="color:black"><u>WHAT?</u></b>
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<ul style="color:black"><li>Our project is directed towards converting astrocytes from glial scars into functional neurons</li></ul>
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<a href="https://2014.igem.org/Team:Lethbridge"style="color:#000000">Home </a> </td>
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<a href="https://2014.igem.org/Team:Lethbridge/Team"style="color:#000000"> Team </a> </td>
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<a href="https://igem.org/Team.cgi?year=2014&team_name=Lethbridge"style="color:#000000"> Official Team Profile </a></td>
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<a href="https://2014.igem.org/Team:Lethbridge/Project"style="color:#000000"> Project</a></td>
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<a href="https://2014.igem.org/Team:Lethbridge/Parts"style="color:#000000"> Parts</a></td>
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<a href="https://2014.igem.org/Team:Lethbridge/Modeling"style="color:#000000"> Modeling</a></td>
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<a href="https://2014.igem.org/Team:Lethbridge/Safety"style=" color:#000000"> Safety </a></td>
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<a href="https://2014.igem.org/Team:Lethbridge/Attributions"style="color:#000000"> Attributions </a></td>
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<h2>Sponsors</h2>
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<p><center><image src="https://static.igem.org/mediawiki/2014/1/13/AITFBigGood_2.png"; width="300px"; height="100px" />&nbsp;&nbsp;&nbsp;&nbsp;
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<tr><td colspan="3"> <h3> Requirements </h3></td></tr>
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<p> Please be sure to keep these links, your audience will want to find your: </p>
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<li><a href="https://2014.igem.org/Team:Lethbridge">Home</a> </li>
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<li><a href="https://2014.igem.org/Team:Lethbridge/Team">Team</a> </li>
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<li><a href="https://igem.org/Team.cgi?year=2013&team_name=Lethbridge">Official Team Profile</a> </li>
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<li><a href="https://2014.igem.org/Team:Lethbridge/Project">Project</a> </li>
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<li><a href="https://2014.igem.org/Team:Lethbridge/Parts">Parts</a> </li>
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<li><a href="https://2014.igem.org/Team:Lethbridge/Safety">Safety</a> </li>
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<li><a href="https://2014.igem.org/Team:Lethbridge/Attributions">Attributions</a> </li>
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<p>There are a few wiki requirements teams must follow:</p>
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<li>All pages, images and files must be hosted on the <a href ="https://2014.igem.org/Special:Upload">  2014.igem.org server</a>. </li>
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<li>All pages must be created under the team’s name space.</li>
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<li>As part of your documentation, keep the links from the menu to the left. </li>
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<p>Visit the <a href="https://2014.igem.org/Wiki_How-To"> Wiki How To page </a> for a complete list of requirements, tips and other useful information. </p>
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<tr><td colspan="3" > <h3> Tips  </h3></td></tr>
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<p>We are currently working on providing teams with some easy to use design templates.
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<br> In the meantime you can also view other team wikis for inspiration! Here are some very good examples</p>
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<li> <a href="https://2013.igem.org/Team:SDU-Denmark/"> 2013 SDU Denmark </a> </li>
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<li> <a href="https://2013.igem.org/Team:SYSU-China">2013 SYSU China</a> </li>
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<li> <a href="https://2013.igem.org/Team:Shenzhen_BGIC_ATCG"> 2013 Shenxhen BGIG ATCG </a></li>
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<li> <a href="https://2013.igem.org/Team:Colombia_Uniandes">2013 Colombia Unianades </a></li>
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<li> <a href="https://2013.igem.org/Team:Lethbridge">2013 Lethbridge</a></li>
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<p>For a full wiki list, you can visit <a href="https://igem.org/Team_Wikis?year=2013">iGEM 2013 web sites </a> and <a href="https://igem.org/Team_Wikis?year=2012">iGEM 2012 web sites</a> lists. </p>
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<p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p>
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<li>State your accomplishments! Tell people what you have achieved from the start. </li>
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<li>Be clear about what you are doing and what you plan to do.</li>
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<li>You have a global audience! Consider the different backgrounds that your users come from.</li>
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<li>Avoid using very small fonts and low contrast colors; information should be easy to read.  </li>
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<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="">iGEM 2013 calendar</a> </li>
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<li>Have lots of fun! </li>
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Latest revision as of 03:58, 18 October 2014


Project Summary

Every year, traumatic brain injury, stroke and neurodegenerative disease collectively cost the Canadian medical system millions of dollars while effective neural regenerative therapies remain elusive. Astrogliosis, a cellular response common to such neural insults, leads to the formation of a non-functional “glial scar” and an inhibitory cellular environment that impedes neural regeneration and further recovery. Our proposed project involves engineering microglia, the mobile immune cells of the brain, to package and deliver a therapeutic plasmid DNA construct specifically to the reactive astrocytes that comprise these glial scars. The plasmids will contain a reprogramming factor that converts reactive astrocytes into new neurons, helping to both restore the functional neuronal population and permit regrowth of damaged connections. Altogether, this study provides the basis for a novel, tissue-specific, personalized, non-immunogenic, non-invasive neural rehabilitative therapy that has the potential to significantly improve current methods of stimulating functional recovery following brain injury or disease onset.

WHAT?

  • Our project is directed towards converting astrocytes from glial scars into functional neurons

Sponsors


         




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