Team:Calgary

From 2014.igem.org

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<img src="https://static.igem.org/mediawiki/2014/2/28/2014UCalgaryHomeRobot.png" id="HomeRobot">
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<h2 class="HomeBsDetectorH2"><i>B.s.</i> Detector</h2>
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<p class="HomeBsDetectorP">We are developing a novel, genome-based, point-of-care synthetic biological device to <b>simultaneously diagnose multiple infectious diseases</b> that are prevalent worldwide.</p>
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<td style="border:1px solid black;" colspan="3" align="center" height="150px" bgColor=#FF404B>
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<h1 >WELCOME TO iGEM 2014! </h1>
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<p>Your team has been approved and you are ready to start the iGEM season!
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<br>On this page you can document your project, introduce your team members, document your progress <br> and share your iGEM experience with the rest of the world! </p>
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<br>
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<p style="color:#E7E7E7"> <a href="https://2014.igem.org/wiki/index.php?title=Team:Calgary&action=edit"style="color:#FFFFFF"> Click here  to edit this page!</a> </p>
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<a href="https://2014.igem.org/Team:Calgary"style="color:#000000">Home </a> </td>
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<td style="border:1px solid black;" align="center" height ="45px" onMouseOver="this.bgColor='#d3d3d3'" onMouseOut="this.bgColor='#e7e7e7'" bgColor=#e7e7e7>
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<a href="https://2014.igem.org/Team:Calgary/Team"style="color:#000000"> Team </a> </td>
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<td style="border:1px solid black;" align="center"  height ="45px"  onMouseOver="this.bgColor='#d3d3d3'" onMouseOut="this.bgColor='#e7e7e7'" bgColor=#e7e7e7>
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<a href="https://igem.org/Team.cgi?year=2014&team_name=Calgary"style="color:#000000"> Official Team Profile </a></td>
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<td style="border:1px solid black" align="center"  height ="45px" onMouseOver="this.bgColor='#d3d3d3'" onMouseOut="this.bgColor='#e7e7e7'" bgColor=#e7e7e7> 
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<a href="https://2014.igem.org/Team:Calgary/Project"style="color:#000000"> Project</a></td>
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<td style="border:1px solid black;" align="center"  height ="45px" onMouseOver="this.bgColor='#d3d3d3'" onMouseOut="this.bgColor='#e7e7e7'" bgColor=#e7e7e7>
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<a href="https://2014.igem.org/Team:Calgary/Parts"style="color:#000000"> Parts</a></td>
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<a href="https://2014.igem.org/Team:Calgary/Modeling"style="color:#000000"> Modeling</a></td>
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<a href="https://2014.igem.org/Team:Calgary/Notebook"style="color:#000000"> Notebook</a></td>
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<a href="https://2014.igem.org/Team:Calgary/Safety"style=" color:#000000"> Safety </a></td>
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<a href="https://2014.igem.org/Team:Calgary/Attributions"style="color:#000000"> Attributions </a></td>
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<td align ="center"> <a href="https://2014.igem.org/Main_Page"> <img src="https://static.igem.org/mediawiki/igem.org/6/60/Igemlogo_300px.png" width="55px"></a> </td>
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<tr><td colspan="3"> <h3> Requirements </h3></td></tr>
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<p> Please be sure to keep these links, your audience will want to find your: </p>
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<!-- Links to other team pages -->
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<ul>
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<li><a href="https://2014.igem.org/Team:Calgary">Home</a> </li>
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<li><a href="https://2014.igem.org/Team:Calgary/Team">Team</a> </li>
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<li><a href="https://igem.org/Team.cgi?year=2013&team_name=Calgary">Official Team Profile</a> </li>
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<li><a href="https://2014.igem.org/Team:Calgary/Project">Project</a> </li>
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<li><a href="https://2014.igem.org/Team:Calgary/Parts">Parts</a> </li>
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<li><a href="https://2014.igem.org/Team:Calgary/Modeling">Modeling</a> </li>
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<li><a href="https://2014.igem.org/Team:Calgary/Notebook">Notebook</a> </li>
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<li><a href="https://2014.igem.org/Team:Calgary/Safety">Safety</a> </li>
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<li><a href="https://2014.igem.org/Team:Calgary/Attributions">Attributions</a> </li>
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<td > </td>
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<p>There are a few wiki requirements teams must follow:</p>
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<li>All pages, images and files must be hosted on the <a href ="https://2014.igem.org/Special:Upload">  2014.igem.org server</a>. </li>
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<li>All pages must be created under the team’s name space.</li>
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<li>As part of your documentation, keep the links from the menu to the left. </li>
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<li>Do not use flash in wiki code. </li>
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<li>The <a href="https://static.igem.org/mediawiki/igem.org/6/60/Igemlogo_300px.png"> iGEM logo </a> should be placed on the upper part of every page and should link to <a href="https://2014.igem.org/Main_Page">2014.igem.org</a>.</li>
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<p>Visit the <a href="https://2014.igem.org/Wiki_How-To"> Wiki How To page </a> for a complete list of requirements, tips and other useful information. </p>
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<tr><td colspan="3" > <h3> Tips  </h3></td></tr>
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<p>We are currently working on providing teams with some easy to use design templates.
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<br> In the meantime you can also view other team wikis for inspiration! Here are some very good examples</p>
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<section class="Content Text Color-Light" id="HomeMisdiagnosis">
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<li> <a href="https://2013.igem.org/Team:SDU-Denmark/"> 2013 SDU Denmark </a> </li>
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<h2 class="HomeMisdiagnosisH2">Misdiagnosis of Infectious Diseases</h2>
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<li> <a href="https://2013.igem.org/Team:SYSU-China">2013 SYSU China</a> </li>
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<p class="HomeMisdiagnosisP">Infectious diseases such as typhoid fever, meningitis, pneumonia and visceral leishmaniasis have similar clinical manifestations as malaria, thus are <b>often misdiagnosed</b> in resource-poor developing countries lacking suitable medical diagnostic facilities. Failure to properly identify such diseases prevents medical professionals from administering appropriate treatments in a timely manner, which results in economic costs and human suffering. In order to address this issue, the iGEM 2014 team is developing a <b>novel, genome-based, rapid point-of-care synthetic biological device</b> to simultaneously diagnose multiple infectious diseases.</p>
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<li> <a href="https://2013.igem.org/Team:Shenzhen_BGIC_ATCG"> 2013 Shenxhen BGIG ATCG </a></li>
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<li> <a href="https://2013.igem.org/Team:Colombia_Uniandes">2013 Colombia Unianades </a></li>
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<li> <a href="https://2013.igem.org/Team:Lethbridge">2013 Lethbridge</a></li>
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<p>For a full wiki list, you can visit <a href="https://igem.org/Team_Wikis?year=2013">iGEM 2013 web sites </a> and <a href="https://igem.org/Team_Wikis?year=2012">iGEM 2012 web sites</a> lists. </p>
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<section class="Content Text Color-Orange" id="HomeCaseStudy">
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<img src="https://static.igem.org/mediawiki/2014/d/d6/2014UCalgaryHomeHuman.png" id="HomeHuman">
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<h2 class="HomeCaseStudyH2">Global Impact</h2>
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<p class="HomeCaseStudyP">Recent studies show that malaria-endemic countries have a 1-3% decreased economic growth rate than countries without malaria. With a widening gap of prosperity between these group of countries, it is predicted that malaria cases <b>will double over the next 20 years</b>. From the public-health perspective, misdiagnosis of malaria results in <b>excessive reporting of malaria cases</b>, while those that mimic malaria are under-reported.</p>
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<p class="HomeCaseStudyP">Patients who test negative for malaria but show its clinical signs and symptoms are often given antimalarial drugs despite their diagnosis. The over-prescription of antimalarials fosters an environment for the emergence of <b>drug resistance</b> and worsens the patient's condition.</p>
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<h2 class="HomeOurDeviceH2">Our Device, Our Idea</h2>
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<p class="HomeOurDeviceP">We are engineering <b><i>Bacillus subtilis</i></b> to generate chromophoric reporter proteins in response to pathogenic genetic markers.</p>
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<p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p>
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<section class="Content Text Color-Blue" id="HomeComponents">
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<h2 class="HomeComponentsH2">Components of Our System</h2>
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<div class="buttoncontainer">
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<div class="button"><a href="https://2014.igem.org/Team:Calgary/Project/BsDetector"><img src="https://static.igem.org/mediawiki/2014/0/00/2014UCalgaryButtonDetector.png"/></a></div>
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<div class="button"><a href="https://2014.igem.org/Team:Calgary/Project/BsDetector/GeneticCircuit"><img src="https://static.igem.org/mediawiki/2014/c/c5/2014UCalgaryButtonGeneticCircuit.png"/></a></div>
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<div class="button"><a href="https://2014.igem.org/Team:Calgary/Project/Collaboration"><img src="https://static.igem.org/mediawiki/2014/7/7e/2014UCalgaryButtonCollaboration.png"/></a></div>
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<div class="button"><a href="https://2014.igem.org/Team:Calgary/PoliciesAndPractices"><img src="https://static.igem.org/mediawiki/2014/0/0f/2014UCalgaryButtonPolicy.png"/></a></div>
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<li>State your accomplishments! Tell people what you have achieved from the start. </li>
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<li>Be clear about what you are doing and what you plan to do.</li>
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<li>You have a global audience! Consider the different backgrounds that your users come from.</li>
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<li>Make sure information is easy to find; nothing should be more than 3 clicks away.  </li>
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<li>Avoid using very small fonts and low contrast colors; information should be easy to read.  </li>
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<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="">iGEM 2013 calendar</a> </li>
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<li>Have lots of fun! </li>
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Latest revision as of 03:55, 18 October 2014

B.s. Detector

We are developing a novel, genome-based, point-of-care synthetic biological device to simultaneously diagnose multiple infectious diseases that are prevalent worldwide.

Misdiagnosis of Infectious Diseases

Infectious diseases such as typhoid fever, meningitis, pneumonia and visceral leishmaniasis have similar clinical manifestations as malaria, thus are often misdiagnosed in resource-poor developing countries lacking suitable medical diagnostic facilities. Failure to properly identify such diseases prevents medical professionals from administering appropriate treatments in a timely manner, which results in economic costs and human suffering. In order to address this issue, the iGEM 2014 team is developing a novel, genome-based, rapid point-of-care synthetic biological device to simultaneously diagnose multiple infectious diseases.

Global Impact

Recent studies show that malaria-endemic countries have a 1-3% decreased economic growth rate than countries without malaria. With a widening gap of prosperity between these group of countries, it is predicted that malaria cases will double over the next 20 years. From the public-health perspective, misdiagnosis of malaria results in excessive reporting of malaria cases, while those that mimic malaria are under-reported.

Patients who test negative for malaria but show its clinical signs and symptoms are often given antimalarial drugs despite their diagnosis. The over-prescription of antimalarials fosters an environment for the emergence of drug resistance and worsens the patient's condition.

Our Device, Our Idea

We are engineering Bacillus subtilis to generate chromophoric reporter proteins in response to pathogenic genetic markers.

Components of Our System

Retrieved from "http://2014.igem.org/Team:Calgary"