Team:UMaryland

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<li id="current" class=" active item101 level0 first"><span class="mymarg"><a class="yjanchor  first activepath " href="https://2014.igem.org/Team:UMaryland"><span class="yjm_has_none"><span class="yjm_title">Homepage</span></span></a></span></li><li class="item104 level0"><span class="mymarg"><a class="yjanchor " href="https://2014.igem.org/Team:UMaryland/photos"><span class="yjm_has_none"><span class="yjm_title">Photos</span></span></a></span></li><li class="haschild item105 level0"><span class="child"><a class="yjanchor " href="https://2014.igem.org/Team:UMaryland/meetourteam"><span class="yjm_has_none"><span class="yjm_title">Team</span></span></a></span><ul class="subul_main level1"><li class="bl"></li><li class="tl"></li><li class="tr"></li><li class="item293 level1 first"><span class="mymarg"><a class="yjanchor  first" href="https://2014.igem.org/Team:UMaryland/meetourteam"><span class="yjm_has_none"><span class="yjm_title">Meet Our Team Members</span></span></a></span></li><li class="item116 level1"><span class="mymarg"><a class="yjanchor " href="https://igem.org/Team.cgi?id=1489"><span class="yjm_has_none"><span class="yjm_title">iGEM Page</span></span></a></span></li><li class="item117 level1"><span class="mymarg"><a class="yjanchor " href="https://2014.igem.org/Team:UMaryland/team/attributions"><span class="yjm_has_none"><span class="yjm_title">Attributions</span></span></a></span></li><li class="item300 level1 lilast"><span class="mymarg"><a class="yjanchor last" href="https://2014.igem.org/Team:UMaryland/team/sponsors"><span class="yjm_has_none"><span class="yjm_title">Sponsors</span></span></a></span></li><li class="right"></li><li class="br"></li></ul></li><li class="haschild item112 level0"><span class="child"><a class="yjanchor yjscroll" href="#"><span class="yjm_has_none"><span class="yjm_title">Project</span></span></a></span><ul class="subul_main level1"><li class="bl"></li><li class="tl"></li><li class="tr"></li><li class="item138 level1 first"><span class="mymarg"><a class="yjanchor  first" href="https://2014.igem.org/Team:UMaryland/project/overview"><span class="yjm_has_none"><span class="yjm_title">Overview</span></span></a></span></li><li class="item145 level1"><span class="mymarg"><a class="yjanchor " href="https://2014.igem.org/Team:UMaryland/project/background"><span class="yjm_has_none"><span class="yjm_title">Background</span></span></a></span></li><li class="item144 level1"><span class="mymarg"><a class="yjanchor " href="https://2014.igem.org/Team:UMaryland/project/biobricks"><span class="yjm_has_none"><span class="yjm_title">parts (BioBricks)</span></span></a></span></li><li class="item102 level1"><a class="yjanchor " href="https://2014.igem.org/Team:UMaryland/project/results" target="_blank" ><span class="yjm_has_none"><span class="yjm_title">Results</span></span></a></li><li class="item254 level1"><span class="mymarg"><a class="yjanchor " href="https://2014.igem.org/Team:UMaryland/project/futureapplications"><span class="yjm_has_none"><span class="yjm_title">future applications</span></span></a></span></li><li class="item301 level1 lilast"><span class="mymarg"><a class="yjanchor last" href="https://igem.org/Safety/Safety_Form?team_id=1489"><span class="yjm_has_none"><span class="yjm_title">Safety</span></span></a></span></li><li class="right"></li><li class="br"></li></ul></li><li class="haschild item234 level0"><span class="child"><a class="yjanchor " href="#"><span class="yjm_has_none"><span class="yjm_title">Notebook</span></span></a></span><ul class="subul_main level1"><li class="bl"></li><li class="tl"></li><li class="tr"></li><li class="item303 level1 first lilast"><span class="mymarg"><a class="yjanchor  firstlast" href="https://2014.igem.org/Team:UMaryland/notebook"><span class="yjm_has_none"><span class="yjm_title">Wetlab Notebook</span></span></a></span></li><li class="right"></li><li class="br"></li></ul></li><li class="haschild item123 level0"><span class="child"><a class="yjanchor " href="#"><span class="yjm_has_none"><span class="yjm_title">Human Practices</span></span></a></span><ul class="subul_main level1"><li class="bl"></li><li class="tl"></li><li class="tr"></li><li class="item106 level1 first"><span class="mymarg"><a class="yjanchor  first" href="https://2014.igem.org/Team:UMaryland/humanprac/overview"><span class="yjm_has_none"><span class="yjm_title">Overview | Mission Statement</span></span></a></span></li><li class="haschild item129 level1"><span class="child subparent"><a class="yjanchor  grouptitle" href="https://2014.igem.org/Team:UMaryland/humanprac/publicschool"><span class="yjm_has_none"><span class="yjm_title">Public School Outreach</span></span></a></span><ul class="subul_main level2"><li class="bl"></li><li class="tl"></li><li class="tr"></li><li class="item134 level2 first lilast"><span class="mymarg"><a class="yjanchor  firstlast" href="https://2014.igem.org/Team:UMaryland/humanprac/publicschool"><span class="yjm_has_none"><span class="yjm_title">HighSchool</span></span></a></span></li><li class="right"></li><li class="br"></li></ul></li><li class="item131 level1"><span class="mymarg"><a class="yjanchor " href="https://2014.igem.org/Team:UMaryland/humanprac/community"><span class="yjm_has_none"><span class="yjm_title">Community Interaction</span></span></a></span></li><li class="item132 level1 lilast"><span class="mymarg"><a class="yjanchor last" href="https://2014.igem.org/Team:UMaryland/humanprac/publicawareness"><span class="yjm_has_none"><span class="yjm_title">Public Awareness</span></span></a></span></li><li class="right"></li><li class="br"></li></ul></li></ul></div>
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<div id="yjsg2" class="yjsg_grid"><div id="adv1" class="yjsgxhtml only_mod yjsgsfx-baseline-intro"><div class="yjsquare baseline-intro modid96"><div class="yjsquare_in"><p><strong> <span style="font-size: 2em;">UMaryland iGEM</span></strong></p>
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<p>Home of The University of Maryland's first iGEM team.</p>
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<p><a href="https://2014.igem.org/Team:UMaryland/project/overview"><br /><br /></a></p>
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<p><a href="https://2014.igem.org/Team:UMaryland/project/overview" target="_self"><img src="https://static.igem.org/mediawiki/parts/5/55/UMIgem_logo_%281%29.png" border="0" alt="Our research heavily focuses on saving the Chesapeake Bay through protecting the oysters" width="1000" height="364" onmouseover="this.src='https://static.igem.org/mediawiki/parts/f/f2/Umarylandigeminfographic.jpg'" onmouseout="this.src= 'https://static.igem.org/mediawiki/parts/5/55/UMIgem_logo_%281%29.png'" style="border: 0;" /></a></p></div></div></div></div> </div>
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<h4>Project</h4>
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<p><img src="http://static.guim.co.uk/sys-images/Lifeandhealth/Pix/pictures/2008/11/05/oyster1.jpg" border="0" width="80" height="48" /></p>
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<a class="rm_content" href="https://2014.igem.org/Team:UMaryland/project/overview">Read More</a></div>
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<h4>Notebook</h4>
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<p><img src="https://static.igem.org/mediawiki/parts/c/c8/UmarylandNotebook.jpg" border="0" width="67" height="67" style="border: 0;" /></p>
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<a class="rm_content" href="https://2014.igem.org/Team:UMaryland/notebook">Read More</a></div>
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<h4>human practices</h4>
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<a class="rm_content" href="https://2014.igem.org/Team:UMaryland/humanprac/overview">Read More</a></div>
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<div class="Content-OurServices">
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<h4>Photo Album</h4>
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<a class="rm_content" href="https://2014.igem.org/Team:UMaryland/photos">Read More</a></div>
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<p><a href="https://2014.igem.org/Team:UMaryland/photos"><img src="https://static.igem.org/mediawiki/parts/a/a5/Umarylandpanoramic.jpg" border="0" width="1010" height="202" style="border: 0;" /></a></p>
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Graduate Student Advisors</a>
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Undergraduate Students</a>
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<a href="https://2014.igem.org/Team:UMaryland/HumanPractices"style="color:#000000"> Human Practices </a></td>
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<td align ="center"> <a href="https://2014.igem.org/Main_Page"> <img src="https://static.igem.org/mediawiki/igem.org/6/60/Igemlogo_300px.png" width="55px"></a> </td>
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<tr><td colspan="3"> <h3> Project Description </h3></td></tr>
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<p>
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    The Chesapeake Bay is one of the most treasured wildlife biomes in Maryland. However, overfishing, pollution, and the need for commercial trade has
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    disrupted this habitat.
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</p>
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<p>
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    A major biological reason for this decline in the Eastern oyster population has been an oyster pathogen called <em>Perkinsus marinus</em>, a unicellular
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    protist which causes an infection known as Dermo in oyster tissues. <em>P. marinus</em> has been shown to infest oysters by entering their hemocytes via
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    induced phagocytosis. When inside the hemocyte, this parasite is capable of resisting the reactive oxygen species generated by the oyster, allowing it to
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    proliferate inside the oyster cells. The growth of <em>P. marinus</em> is eventually fatal to the oyster.
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<p>
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    It is believed that <em>P. marinus </em>enters oyster hemocytes utilizing a galectin called CvGal1 that expressed and secreted by hemocytes. Our goal is to
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    exploit the ability of CvGal1 to bind to <em>P. marinus</em> in order to design a biosensor for the detection of this pathogen. As CvGal1 is a soluble
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    protein, we need a mechanism to anchor it to the outer cell membrane. To accomplish this, we are interested in fusion CvGal1 to the C-terminus of the
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transmembrane domain of OmpA, an integral outer membrane protein. By generating an OmpA-CvGal1 fusion protein, we hope to express this protein on the   <em>E. coli</em> surface in order to trigger a signal transduction cascade within the bacterium via the Cpx two component system. This signal cascade would
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    lead to the production of a signal molecule, such as GFP. Thus, <em>P. marinus </em>binding to CvGal1 would trigger the creation of a visual marker for the
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    parasite.
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<p>
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    We are currently also investigating the potential of generating a response from <em>E. coli</em> to mitigate the pathogenicity of <em>P. marinus</em>. This
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    could potentially be done by generating cleavage enzymes to digest ligands on the surface of <em>P. marinus</em> that bind to CvGal1, reducing the ability
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    of oysters to recognize and phagocytose the pathogen.
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<p>
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    Although laboratory methods for Dermo detection using ELISA exist, they are currently not capable of detecting the disease in real time. In the time needed
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    to conduct a laboratory test, Dermo could have easily spread to new locations. This biosensor would help to accurately pinpoint Dermo infestation levels in
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    real time. If we can pinpoint the location of <em>P. marinus</em>, then we can ultimately develop a biosensor that can react to Dermo with targeted
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    destruction.
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<tr><td colspan="3"> <h3> Requirements </h3></td></tr>
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<img src="https://static.igem.org/mediawiki/2014/thumb/5/54/UMD_IGEM_GFP_PHOTO.jpg/450px-UMD_IGEM_GFP_PHOTO.jpg" >
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</div></div></div><div id="user13" class="yjsgxhtml lastModule"><div class="yjsquare modid127"><div class="yjsquare_in"><p><a href="https://2014.igem.org/Team:UMaryland/meetourteam"><p><a href="https://2014.igem.org/Team:UMaryland/meetourteam"><br /><br /></a></p>
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<p><a href="https://2014.igem.org/Team:UMaryland/meetourteam" target="_self"><img src="https://static.igem.org/mediawiki/parts/7/7a/Umarylandlabphoto.jpg" border="0" alt="Our research heavily focuses on saving the Chesapeake Bay through protecting the oysters" width="500" height="150" onmouseover="this.src='https://static.igem.org/mediawiki/parts/d/d4/TeamPhoto.JPG'" onmouseout="this.src= 'https://static.igem.org/mediawiki/parts/7/7a/Umarylandlabphoto.jpg'" style="border: 0;" /></a></p></div></div></div></div></div> <div class="yjsg7_before"><div id="yjsg7" class="yjsg_grid yjsgsitew"><div id="user23" class="yjsgxhtml only_mod"><div class="yjsquare modid117"><div class="h2_holder"><h2 class="module_title"><span class="title_split titlesplit0">About</span> <span class="title_split titlesplit1">Umaryland</span></h2></div><div class="yjsquare_in"><p>UMaryland 2014 is the inaugural iGEM team of the University of Maryland, College Park. We are a combined effort of several departments and numerous faculty mentors. Although it is only our first year, we believe our hard work and dedication has paid off. We can't wait for this year's competition! GO TERPS!</p></div></div></div></div></div> <div class="footer_holders footer"><!-- footer -->
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<script type="text/javascript"> var logo_w = '240'; var site_w = '1200'; var site_f = '13px'; var sp='https://2014.igem.org/Team:UMaryland'; var tp ='baseline'; var compileme =0; var fontc ='baseline_73331408039633'; var bootstrapv='bootstrap2'; var yver='2'; var yjsglegacy='1'; var yjsgrtl='2'; var menuanimation='fade';var menuanimationspeed=300; var YJSG_topmenu_font = '13px'; (function($){ $(window).load(function(){ $('.horiznav').SmoothDropJQ({ contpoz:0, horizLeftOffset: 20, horizRightOffset: -20, horizTopOffset: 20, verticalTopOffset:30, verticalLeftOffset: 10, maxOutside: 50 }); }) })(jQuery); </script>
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  <span class="yjmm_select" id="yjmm_selectid">Homepage</span>
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<p>There are a few wiki requirements teams must follow:</p>
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            <option value="https://2014.igem.org/Team:UMaryland" selected="selected">&nbsp;Homepage</option>
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<ul>
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            <option value="https://2014.igem.org/Team:UMaryland/photos">&nbsp;Photos</option>
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<li>All pages, images and files must be hosted on the <a href ="https://2014.igem.org/Special:Upload">  2014.igem.org server</a>. </li>
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            <option value="https://2014.igem.org/Team:UMaryland/meetourteam">&nbsp;Team</option>
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<li>All pages must be created under the team’s name space.</li>
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            <option value="https://2014.igem.org/Team:UMaryland/meetourteam">&nbsp;--Meet Our Team Members</option>
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<li>As part of your documentation, keep the links from the menu to the left. </li>
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            <option value="https://igem.org/Team.cgi?id=1489">&nbsp;--iGEM Page</option>
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<li>Do not use flash in wiki code. </li>
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            <option value="https://2014.igem.org/Team:UMaryland/team/attributions">&nbsp;--Attributions</option>
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<li>The <a href="https://static.igem.org/mediawiki/igem.org/6/60/Igemlogo_300px.png"> iGEM logo </a> should be placed on the upper part of every page and should link to <a href="https://2014.igem.org/Main_Page">2014.igem.org</a>.</li>
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            <option value="https://2014.igem.org/Team:UMaryland/team/sponsors">&nbsp;--Sponsors</option>
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            <option value="#">&nbsp;Project</option>
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<p>Visit the <a href="https://2014.igem.org/Wiki_How-To"> Wiki How To page </a> for a complete list of requirements, tips and other useful information. </p>
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            <option value="https://2014.igem.org/Team:UMaryland/project/overview">&nbsp;--Overview</option>
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            <option value="https://2014.igem.org/Team:UMaryland/project/background">&nbsp;--Background</option>
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            <option value="https://2014.igem.org/Team:UMaryland/project/biobricks">&nbsp;--parts (BioBricks)</option>
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            <option value="https://2014.igem.org/Team:UMaryland/project/results">&nbsp;--Results</option>
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            <option value="https://igem.org/Safety/Safety_Form?team_id=1489">&nbsp;--Safety</option>
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            <option value="#">&nbsp;Notebook</option>
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            <option value="https://2014.igem.org/Team:UMaryland/notebook">&nbsp;--Wetlab Notebook</option>
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            <option value="#">&nbsp;Human Practices</option>
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            <option value="https://2014.igem.org/Team:UMaryland/humanprac/overview">&nbsp;--Overview | Mission Statement</option>
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<!--tips  -->
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            <option value="https://2014.igem.org/Team:UMaryland/humanprac/publicschool">&nbsp;--Public School Outreach</option>
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<tr><td colspan="3" > <h3> Tips  </h3></td></tr>
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            <option value="https://2014.igem.org/Team:UMaryland/humanprac/publicschool">&nbsp;---HighSchool</option>
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            <option value="https://2014.igem.org/Team:UMaryland/humanprac/community">&nbsp;--Community Interaction</option>
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<tr>
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            <option value="https://2014.igem.org/Team:UMaryland/humanprac/publicawareness">&nbsp;--Public Awareness</option>
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<td width="45%" valign="top">  
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        </select>
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<p>We are currently working on providing teams with some easy to use design templates.
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</div> </body>
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<br> In the meantime you can also view other team wikis for inspiration! Here are some very good examples</p>
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<ul>
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<li> <a href="https://2013.igem.org/Team:SDU-Denmark/"> 2013 SDU Denmark </a> </li>
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<li> <a href="https://2013.igem.org/Team:SYSU-China">2013 SYSU China</a> </li>
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<li> <a href="https://2013.igem.org/Team:Shenzhen_BGIC_ATCG"> 2013 Shenxhen BGIG ATCG </a></li>
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<li> <a href="https://2013.igem.org/Team:Colombia_Uniandes">2013 Colombia Unianades </a></li>
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<li> <a href="https://2013.igem.org/Team:Lethbridge">2013 Lethbridge</a></li>
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</ul>
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<p>For a full wiki list, you can visit <a href="https://igem.org/Team_Wikis?year=2013">iGEM 2013 web sites </a> and <a href="https://igem.org/Team_Wikis?year=2012">iGEM 2012 web sites</a>  lists. </p>
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</td>
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<td> </td>
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<td width="45%">  
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<ul>
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<li>State your accomplishments! Tell people what you have achieved from the start. </li>
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<li>Be clear about what you are doing and what you plan to do.</li>
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<li>You have a global audience! Consider the different backgrounds that your users come from.</li>
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<li>Make sure information is easy to find; nothing should be more than 3 clicks away.  </li>
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<li>Avoid using very small fonts and low contrast colors; information should be easy to read.  </li>
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<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="">iGEM 2013 calendar</a> </li>
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<li>Have lots of fun! </li>
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Latest revision as of 19:39, 17 October 2014

UMaryland iGEM 2014

UMaryland iGEM

Project

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Notebook

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human practices

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Photo Album

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About Umaryland

UMaryland 2014 is the inaugural iGEM team of the University of Maryland, College Park. We are a combined effort of several departments and numerous faculty mentors. Although it is only our first year, we believe our hard work and dedication has paid off. We can't wait for this year's competition! GO TERPS!

Retrieved from "http://2014.igem.org/Team:UMaryland"