Team:Paris Bettencourt

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                                            <!-- Code by the 2014 Paris Bettencourt -->
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<h1></h1>
 
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<h2>Paris Bettencourt 2014</h2>
 
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</div>
 
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</head>
 
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<body>
 
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<p>
 
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</br>
 
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<ul id="menu-accordeon">
 
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt" id = "link">+ Home </a></li>
 
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Team" id = "link">+ Team </a></li>
 
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<li><a href="https://igem.org/Team.cgi?year=2014&team_name=Paris_Bettencourt" id = "link">+ Official Team Profile </a></li>
 
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Project" id = "link">+ Project</a>
 
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<ul>
 
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Odor_Library" id="link">Odor Library</a></li>
 
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Old_People_Smell" id="link">Old People Smell</a></li>
 
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/TMAU" id="link">TMAU</a></li>
 
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Citizen_Science" id="link">Citizen Science</a></li>
 
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</ul>
 
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</li>
 
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Parts" id = "link">+ Parts</a></li>
 
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Modeling" id = "link">+ Modeling</a></li>
 
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Notebook" id = "link">+ Notebook</a>
 
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<ul>
 
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Safety" id = "link">+ Safety </a></li>
 
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Attributions" id = "link">+ Attributions </a></li>
 
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</ul>
 
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<a class="twitter-timeline"  href="https://twitter.com/iGEM_Paris"  data-widget-id="486846286729973760" id="twitter">Tweets de @iGEM_Paris</a>
 
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</div>
 
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<div id=intro>
 
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<h6 id=h6>It has always been the objective of iGEM Paris Bettencourt to conduct novel
 
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projects. This year, our team has decided to explore a topic that has rarely been
 
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approached by synthetic biologists in this competition: odor.
 
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</h6>
 
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</br>
 
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<p id=text>
 
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Human olfaction relies on a tremendous number of cellular receptors that can
 
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detect specific molecules in the air. Upon the detection of combination of these
 
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compounds, a message is sent to the brain, which leads to the perception of one unique
 
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odor. There is considerable work left to do in order to understand the sense of smell,
 
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especially in determining how olfactory receptors operate.
 
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Few synthetic biologists have tried to engineer bacteria to produce smell or to
 
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treat bad smell since the production of odor by microorganisms is not studied often. One
 
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reason for the lack of study in this area is that it is hard to quantify and characterize an
 
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odor. We will overcome this by using odor professionals and commonly used scientific
 
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tools. We want to do this in order to investigate the links between our skin microbiota
 
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and body odor, as well as the perception of one's body odor by others.
 
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</p>
 
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</div>
 
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<div></br></br></br></br></br></br></br></div>
 
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<div id=actualitee>
 
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<h3><a href="https://2014.igem.org/Team:Paris_Bettencourt/Newsletter" id=link>News</a></h3>
 
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<div id=separation></div>
 
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<h4>First MOOC video</h4>
 
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<h5>12/08/2014</h5>
 
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<center><iframe src="//www.youtube.com/embed/1vSOH5xNnGU"></iframe></center>
 
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</br>
 
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</br>
 
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<div id=separation></div>
 
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<a href="https://2014.igem.org/Team:Paris_Bettencourt/Newsletter1"><h4>Newsletter n°1</h4></a>
 
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<h5>from July 28th to August 10th 2014</h5>
 
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<p>We co-founded a biweekly newsletter with the iGEM team from Xiamen University
 
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in China. Currently, there are 8 teams, from 7 different countries involved.
 
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The newsletter has two major parts: project update and team member introduction.
 
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We hope through this activity the teams will be able to keep better record of their own projects,
 
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be able to get feedback from their peers and get to know other young synthetic biologists.
 
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There will also be special issue on interviews with iGEM alumni, as well as past advisors,
 
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from college teams in Germany and Brazil.</p>
 
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                        height : 850px;
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 +
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 +
<p class=definition><b>Body odor is caused by the metabolic action of bacteria on human sweat. Existing deodorants are antibiotic - they kill all skin bacteria including neutral and beneficial species. Where body odor carries a social stigma, alternatives to deodorant are few. </b></p>
 +
<p class=definition>The <b>iGEM Paris Bettencourt 2014 </b>project explores new ways to control body odors through precise modifications of the living microbiome. We target common odors of the armpit and foot, as well as odors specific to old age or genetic disease. We present a BioBrick smell library for mixing genetic perfumes and a CRISPR-mediated technology for isolating naturally odorless bacterial strains.</p>
 +
<p class=definition> Our work represents a probiotic and body-positive approach to body odor that will someday help people to smell <i>just like themselves</i>.</p>
 +
        <div id=results><a href="https://2014.igem.org/Team:Paris_Bettencourt/Results"><img src="https://static.igem.org/mediawiki/2014/8/85/Gotoresultspb.png"></br><p>Jump To Results</p></a></div>
 +
                        </div>
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</div>
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<div id=smell><a class=layout href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Odor_Library"><p class=descript2>Here we present a genetic odor palette. It is built of BioBricks to express enzymes to produce volatile compounds with characteristic smells. We included smells with different tonalities to allow exploration of the "odor space" resulting from combinations of smelly units.</p><img src="https://static.igem.org/mediawiki/2014/b/b1/Smelltheroses.png" class=nameimg><img src="https://static.igem.org/mediawiki/2014/c/ca/Smelltherosesrose.png" class=nameimgr></a></div>
 +
                <div class=separation></div>
 +
<div id=fish><a class=layout href="https://2014.igem.org/Team:Paris_Bettencourt/Project/TMAU"><p class=descript2>Trimethylaminuria (TMAU) is a rare genetic disease causing a strong fish odor to appear in the sweat. Here we engineer skin bacteria to degrade trimethylamine, the odor causing molecule, with the enzyme TMM (trimethylamine monooxygenase).</p><img src="https://static.igem.org/mediawiki/2014/b/b9/Somethingfishy.png" id=fishy class=nameimg><img src="https://static.igem.org/mediawiki/2014/f/fd/Somethingfishyrosepb.png" id=fishy class=nameimgr></a></div>
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                <div class=separation></div>
 +
<div id=shoes><a class=layout href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Foot_Odor"><p class=descript2>Isovaleric acid, the cheesy component of foot odor, is produced by <i>B. subtilis</i> through the leucine degradation pathway. We characterize <i>B. subtilis</i> mutants in this pathway, in vitro and in situ (on socks).</p><img src="https://static.igem.org/mediawiki/2014/3/3a/Goodytwoshoes.png" class=nameimg><img src="https://static.igem.org/mediawiki/2014/d/dd/Goodytwoshoesrosepb.png" class=nameimgr></a></div>
 +
                <div class=separation></div>
 +
<div id=sweat><a class=layout href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Eliminate_Smell"><p class=descript2>Armpit odor comes mainly from aminoacylase enzymes expressed in the genus <i>Corynebacteria</i>. This project is developing CRISPR technology to isolate natural bacterial mutants that lack these enzymes.</p><img src="https://static.igem.org/mediawiki/2014/e/e1/Dontsweatit.png" class=nameimg><img src="https://static.igem.org/mediawiki/2014/a/ac/Dontsweatitrosepb.png" class=nameimgr></a></div>
 +
                <div class=separation></div>
 +
<div id=teen><a class=layout href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Old_People_Smell"><p class=descript2>2-nonenal is "old people smell," a component of sweat that increases with age. Here we isolate and characterize bacterial species that metabolize 2-nonenal and attenuate its characteristic odor.</p><img src="https://static.igem.org/mediawiki/2014/6/6f/Teenspirit.png" class=nameimg><img src="https://static.igem.org/mediawiki/2014/5/57/Teenspiritrosepb.png" class=nameimgr></a></div>
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                            <tr>
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<td><a href="https://2014.igem.org/Team:Paris_Bettencourt/MOOC"><img src="https://static.igem.org/mediawiki/2014/f/f7/PBiconemooc.png"></a></td><td></td>
 +
<td><a href="https://2014.igem.org/Team:Paris_Bettencourt/Citizen_Science"><img src="https://static.igem.org/mediawiki/2014/b/bb/PBiconesscici.png"></a></td><td></td>
 +
<td><a href="https://2014.igem.org/Team:Paris_Bettencourt/The_Smell_Game"><img src="https://static.igem.org/mediawiki/2014/e/e7/PBiconesmellgame.png"></a></td><td></td>
 +
                                <td><a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Art"><img src="https://static.igem.org/mediawiki/2014/3/39/PBiconedesign.png"></a></td>
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                          </tr>
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<td><a href="https://2014.igem.org/Team:Paris_Bettencourt/Newsletter"><img src="https://static.igem.org/mediawiki/2014/7/75/PBiconnews.png"></a></td><td></td>
 +
<td><a href="https://2014.igem.org/Team:Paris_Bettencourt/Minder"><img src="https://static.igem.org/mediawiki/2014/c/c6/PBiconminder.png"></a></td><td></td>
 +
<td><a href="https://2014.igem.org/Team:Paris_Bettencourt/Facts_Smell"><img src="https://static.igem.org/mediawiki/2014/4/4d/PBiconfacts.png"></a></td><td></td>
 +
                              <td><a href="https://2014.igem.org/Team:Paris_Bettencourt/Art_Gallery"><img src="https://static.igem.org/mediawiki/2014/d/d4/PBiconartgal.png"></a></td></tr></table>
 +
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<td id = "cadre"><a href="https://2014.igem.org/Team:Paris_Bettencourt" id = "link">Home </a> </td>
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<td id = "cadre"><a href="https://2014.igem.org/Team:Paris_Bettencourt/Team" id = "link"> Team </a> </td>
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<td id = "cadre"><a href="https://igem.org/Team.cgi?year=2014&team_name=Paris_Bettencourt" id = "link"> Official Team Profile </a></td>
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<td id = "cadre"><a href="https://2014.igem.org/Team:Paris_Bettencourt/Project" id = "link"> Project</a></td>
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<td id = "cadre"><a href="https://2014.igem.org/Team:Paris_Bettencourt/Parts" id = "link"> Parts</a></td>
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<td id = "cadre"><a href="https://2014.igem.org/Team:Paris_Bettencourt/Modeling" id = "link"> Modeling</a></td>
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<td id = "cadre"><a href="https://2014.igem.org/Team:Paris_Bettencourt/Notebook" id = "link"> Notebook</a></td>
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<td id = "cadre"><a href="https://2014.igem.org/Team:Paris_Bettencourt/Safety" id = "link"> Safety </a></td>
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<td id = "cadre"><a href="https://2014.igem.org/Team:Paris_Bettencourt/Attributions" id = "link"> Attributions </a></td>
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<td align ="center"> <a href="https://2014.igem.org/Main_Page"> <img src="https://static.igem.org/mediawiki/igem.org/6/60/Igemlogo_300px.png" width="55px"></a> </td>
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<div id = "API">
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<a class="twitter-timeline"  href="https://twitter.com/iGEM_Paris"  data-widget-id="486846286729973760" id="twitter">Tweets de @iGEM_Paris</a>
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    <script>!function(d,s,id){var js,fjs=d.getElementsByTagName(s)[0],p=/^http:/.test(d.location)?'http':'https';if(!d.getElementById(id)){js=d.createElement(s);js.id=id;js.src=p+"://platform.twitter.com/widgets.js";fjs.parentNode.insertBefore(js,fjs);}}(document,"script","twitter-wjs");</script>
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<tr><td colspan="3"> <h3> Requirements </h3></td></tr>
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<td width="45%"  valign="top">
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<p> Please be sure to keep these links, your audience will want to find your: </p>
+
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+
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<ul>
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt">Home</a> </li>
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Team">Team</a> </li>
+
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<li><a href="https://igem.org/Team.cgi?year=2013&team_name=Paris_Bettencourt">Official Team Profile</a> </li>
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Project">Project</a> </li>
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Parts">Parts</a> </li>
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Modeling">Modeling</a> </li>
+
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Notebook">Notebook</a> </li>
+
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Safety">Safety</a> </li>
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Attributions">Attributions</a> </li>
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</ul>
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</td>
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<td > </td>
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<td width="45%">
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<p>There are a few wiki requirements teams must follow:</p>
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<ul>
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<li>All pages, images and files must be hosted on the <a href ="https://2014.igem.org/Special:Upload">  2014.igem.org server</a>. </li>
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<li>All pages must be created under the team’s name space.</li>
+
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<li>As part of your documentation, keep the links from the menu to the left. </li>
+
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<li>Do not use flash in wiki code. </li>
+
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<li>The <a href="https://static.igem.org/mediawiki/igem.org/6/60/Igemlogo_300px.png"> iGEM logo </a> should be placed on the upper part of every page and should link to <a href="https://2014.igem.org/Main_Page">2014.igem.org</a>.</li>
+
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</ul>
+
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<p>Visit the <a href="https://2014.igem.org/Wiki_How-To"> Wiki How To page </a> for a complete list of requirements, tips and other useful information. </p>
+
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<tr><td colspan="3" > <h3> Tips  </h3></td></tr>
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<tr>
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<td width="45%" valign="top">
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<p>We are currently working on providing teams with some easy to use design templates.
+
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<br> In the meantime you can also view other team wikis for inspiration! Here are some very good examples</p>
+
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+
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<ul>
+
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<li> <a href="https://2013.igem.org/Team:SDU-Denmark/"> 2013 SDU Denmark </a> </li>
+
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<li> <a href="https://2013.igem.org/Team:SYSU-China">2013 SYSU China</a> </li>
+
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<li> <a href="https://2013.igem.org/Team:Shenzhen_BGIC_ATCG"> 2013 Shenxhen BGIG ATCG </a></li>
+
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<li> <a href="https://2013.igem.org/Team:Colombia_Uniandes">2013 Colombia Unianades </a></li>
+
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<li> <a href="https://2013.igem.org/Team:Lethbridge">2013 Lethbridge</a></li>
+
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</ul>
+
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+
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<p>For a full wiki list, you can visit <a href="https://igem.org/Team_Wikis?year=2013">iGEM 2013 web sites </a> and <a href="https://igem.org/Team_Wikis?year=2012">iGEM 2012 web sites</a>  lists. </p>
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<td> </td>
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<td width="45%">
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<p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p>
+
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+
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<ul>
+
-
<li>State your accomplishments! Tell people what you have achieved from the start. </li>
+
-
<li>Be clear about what you are doing and what you plan to do.</li>
+
-
<li>You have a global audience! Consider the different backgrounds that your users come from.</li>
+
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<li>Make sure information is easy to find; nothing should be more than 3 clicks away.  </li>
+
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<li>Avoid using very small fonts and low contrast colors; information should be easy to read.  </li>
+
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<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="">iGEM 2013 calendar</a> </li>
+
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<li>Have lots of fun! </li>
+
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</ul>
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Latest revision as of 18:43, 5 December 2014


Body odor is caused by the metabolic action of bacteria on human sweat. Existing deodorants are antibiotic - they kill all skin bacteria including neutral and beneficial species. Where body odor carries a social stigma, alternatives to deodorant are few.

The iGEM Paris Bettencourt 2014 project explores new ways to control body odors through precise modifications of the living microbiome. We target common odors of the armpit and foot, as well as odors specific to old age or genetic disease. We present a BioBrick smell library for mixing genetic perfumes and a CRISPR-mediated technology for isolating naturally odorless bacterial strains.

Our work represents a probiotic and body-positive approach to body odor that will someday help people to smell just like themselves.

Centre for Research and Interdisciplinarity (CRI)
Faculty of Medicine Cochin Port-Royal, South wing, 2nd floor
Paris Descartes University
24, rue du Faubourg Saint Jacques
75014 Paris, France
+33 1 44 41 25 22/25
paris-bettencourt-igem@googlegroups.com
Copyright (c) 2014 igem.org. All rights reserved.

Retrieved from "http://2014.igem.org/Team:Paris_Bettencourt"