Team:Warwick

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<a href="https://2014.igem.org/Team:Warwick"style="color:#000000"> <b>  </b> </a> <a href=https://2014.igem.org/Team:Warwick><img src="https://static.igem.org/mediawiki/2014/9/9a/Home.png" border="20" align=20px" height ="20px" alt="Image and video hosting by TinyPic">
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<a href="https://2014.igem.org/Team:Warwick/Team"style="color:#000000"> <b>  </b> </a> <a href=https://2014.igem.org/Team:Warwick/Team><img src="https://static.igem.org/mediawiki/2014/0/01/Agents.png" border="20" align=20px" height ="20px" alt="Image and video hosting by TinyPic">
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<a href="https://2014.igem.org/Team:Warwick/Project"style="color:#000000"> <b>  </b> </a> <a href=https://2014.igem.org/Team:Warwick/Project><img src="https://static.igem.org/mediawiki/2014/9/92/Project.png" border="20" align=20px" height ="20px" alt="Image and video hosting by TinyPic">
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<a href="https://2014.igem.org/Team:Warwick/Project"style="color:#000000"> <b>  </b> </a> <a href=https://2014.igem.org/Team:Warwick/Project><img src="https://static.igem.org/mediawiki/2014/7/79/Parts.png" border="20" align=20px" height ="20px" alt="Image and video hosting by TinyPic">
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<a href="https://2014.igem.org/Team:Warwick/Project"style="color:#000000"> <b>  </b> </a> <a href=https://2014.igem.org/Team:Warwick/Modeling><img src="https://static.igem.org/mediawiki/2014/3/3c/Modeling.png" border="20" align=20px" height ="20px" alt="Image and video hosting by TinyPic">
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<a href="https://2014.igem.org/Team:Warwick/Project"style="color:#000000"> <b>  </b> </a> <a href=https://2014.igem.org/Team:Warwick/Notebook><img src="https://static.igem.org/mediawiki/2014/9/95/Notebook.png
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<a href=https://2014.igem.org/Team:Warwick/Attributions><img src="https://static.igem.org/mediawiki/2014/1/16/Sponsors.png
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miRNAs represent a diverse family of eukaryotic biological regulators, which target specific mRNA sequences to prevent translation. Diseases such as Alzheimer’s, cancer, and diabetes exhibit aberrant gene expression. Targeting this via RNA interference has the advantage of being safer than conventional gene therapeutic methods due to lack of integration into the host genome. This motivates our novel approach: a modular, self-replicating RNA system. Specifically, we will create an independently replicating RNA operon in human (HeLa) cells using a HCV derived RNA-dependent RNA polymerase (RdRp, RNA replicase). To test this system, we will produce miRNA-29a to downregulate the dipeptidyl peptidase-IV (DPP-IV), which is elevated in Type 2 diabetes and is the target of many drug studies. Additionally, we will incorporate a control module in the form of a multi-input sensing feedback mechanism which will function as a logic circuit to regulate expression of miRNA.
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            <li> <a href = "/Team:Warwick"> <span>  HOME </span> </a> </li>
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            <li> <a href = "/Team:Warwick/Project"> PROJECT </a> </li>
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            <li> <a href = "/Team:Warwick/Team"> TEAM </a> </li>
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            <li> <a href = "/Team:Warwick/Parts"> PARTS </a> </li>
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            <li> <a href = "/Team:Warwick/Modelling"> MODELLING </a> </li>
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            <li> <a href = "/Team:Warwick/Notebook"> NOTEBOOK </a> </li>
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            <li> <a href = "/Team:Warwick/Human"> POLICY & PRACTICES </a> </li>
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            <!--<li> <a href = "/Team:Warwick/Measurements"> MEASUREMENTS </a> </li>-->
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<h2> Welcome to Warwick iGEM 2014 </h2>
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            <p> <center> Welcome to our website, please take a moment to explore its many intricacies. Herein lie descriptions pertaining to our team, our project and our approach to policy and practices. For further discussion, come find us at the Jamboree and we'll be more than happy to discuss our project. Thank you. <center>
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  <p>Created by: iGEM Warwick 2014</p>
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Latest revision as of 21:01, 25 February 2015

Welcome to Warwick iGEM 2014

Welcome to our website, please take a moment to explore its many intricacies. Herein lie descriptions pertaining to our team, our project and our approach to policy and practices. For further discussion, come find us at the Jamboree and we'll be more than happy to discuss our project. Thank you.

Retrieved from "http://2014.igem.org/Team:Warwick"