Team:UNC-Chapel Hill/Project

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<tr><td  bgColor="#56A0D3"></td> <td colspan="3" width="975px" bgColor="#56A0D3" align="center"> <p style="color:white;font-size:20px">FIGHTING DIABETES </p></td> <td  bgColor="#56A0D3"></td> </tr>
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<tr><td  bgColor="#56A0D3"></td> <td colspan="3" width="975px" bgColor="#56A0D3" align="center"> <p style="color:white;font-size:20px">DIABETES MELLITUS </p></td> <td  bgColor="#56A0D3"></td> </tr>
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<h3>Project Introduction</h3>
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<p>Diabetes is prevalent throughout the world. As a treatable disease, diabetes has fallen in the shadow of more life threatening diseases. Although treatable, diabetes can be life threatening, especially to those who cannot afford treatment options. We propose a protein co trolled system to sense glucose concentrations and release needed proteins I hopes of creating of cost effective and accurate means of glucose sensing via E. Coli. </p>
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<p>Diabetes mellitus is prevalent throughout the world especially in the United States and Mexico. As a treatable disease, diabetes has fallen in the shadow of more life threatening diseases. Although treatable, diabetes can be life threatening, especially to those who cannot afford treatment options. As a solution, we propose a protein controlled system to sense glucose concentrations and release the needed proteins in response. This project executes the first crucial steps of creating a cost effective and accurate means of glucose sensing via the use of Escherichia coli. </p>
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<li>Result 1 - Lorem ipsum ad his scripta blandit partiendo, eum fastidii accumsan euripidis in, eum liber hendrerit an.</li>
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<p>Lorem ipsum ad his scripta blandit partiendo, eum fastidii accumsan euripidis in, eum liber hendrerit an. Qui ut wisi vocibus suscipiantur, quo dicit ridens inciderint id. Quo mundi lobortis reformidans eu, legimus senserit definiebas an eos. Eu sit tincidunt incorrupte definitionem, vis mutat affert percipit cu, eirmod consectetuer signiferumque eu per. In usu latine equidem dolores. Quo no falli viris intellegam, ut fugit veritus placerat per.</p>
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<a href="http://www.diabetes.org/" target="_blank"><img src="https://static.igem.org/mediawiki/2014/thumb/e/ee/UNC_Chapel_Hill_Blue_circle.png/617px-UNC_Chapel_Hill_Blue_circle.png" width="200px" align="right" ></a>
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<p>Diabetes is prevalent throughout the world. As a treatable disease, diabetes has fallen in the shadow of more life threatening diseases. Although treatable, diabetes can be life threatening, especially to those who cannot afford treatment options. We propose a protein co trolled system to sense glucose concentrations and release needed proteins I hopes of creating of cost effective and accurate means of glucose sensing via E. Coli. </p>
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<p id="type1" style="color:#56A0D3; font-size:30px"> Type One Diabetes</p>
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<h2 style="color:#56A0D3"> Solution </h2>
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<p>Type 1 diabetes is characterized by the body’s immune system destroying insulin producing cells which leads the body to no longer producing insulin, a hormone that promotes the uptake of glucose by cells. We provide a solution for this problem through the creation of a pseudo beta cell that is able to produce insulin in the presence of high glucose level. </p>
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<h2 style="color:#56A0D3"> Solution </h2>
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<p>Type 2 diabetes is characterized by the body being inefficient in its use of insulin (insulin resistance) which causes the pancreas to decrease insulin production (insulin deficiency). Our potential solution for this is to have pseudo L cells release GLP-1 to promote insulin production. GLP-1 is an incretin. Incretins are a group of gastrointestinal hormones that stimulate a decrease in blood glucose levels. GLP-1 has been shown to promote insulin production and also to decrease glucagon production. Glucagon is a peptide hormone produced by alpha cells of the pancreas that raises the concentration of glucose in the bloodstream.</p>
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<h2 style="color:#56A0D3"> Thank You </h2>
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Latest revision as of 02:31, 5 August 2014

DIABETES MELLITUS

Project Introduction

Diabetes mellitus is prevalent throughout the world especially in the United States and Mexico. As a treatable disease, diabetes has fallen in the shadow of more life threatening diseases. Although treatable, diabetes can be life threatening, especially to those who cannot afford treatment options. As a solution, we propose a protein controlled system to sense glucose concentrations and release the needed proteins in response. This project executes the first crucial steps of creating a cost effective and accurate means of glucose sensing via the use of Escherichia coli.

Results

  • Result 1 - Lorem ipsum ad his scripta blandit partiendo, eum fastidii accumsan euripidis in, eum liber hendrerit an.
  • Result 2 - Lorem ipsum ad his scripta blandit partiendo, eum fastidii accumsan euripidis in, eum liber hendrerit an.
  • Result 3 - Lorem ipsum ad his scripta blandit partiendo, eum fastidii accumsan euripidis in, eum liber hendrerit an.

Abstract Type One Type Two Modeling References

Abstract

Lorem ipsum ad his scripta blandit partiendo, eum fastidii accumsan euripidis in, eum liber hendrerit an. Qui ut wisi vocibus suscipiantur, quo dicit ridens inciderint id. Quo mundi lobortis reformidans eu, legimus senserit definiebas an eos. Eu sit tincidunt incorrupte definitionem, vis mutat affert percipit cu, eirmod consectetuer signiferumque eu per. In usu latine equidem dolores. Quo no falli viris intellegam, ut fugit veritus placerat per.

Type One Diabetes

Solution

Type 1 diabetes is characterized by the body’s immune system destroying insulin producing cells which leads the body to no longer producing insulin, a hormone that promotes the uptake of glucose by cells. We provide a solution for this problem through the creation of a pseudo beta cell that is able to produce insulin in the presence of high glucose level.

Type Two Diabetes

Solution

Type 2 diabetes is characterized by the body being inefficient in its use of insulin (insulin resistance) which causes the pancreas to decrease insulin production (insulin deficiency). Our potential solution for this is to have pseudo L cells release GLP-1 to promote insulin production. GLP-1 is an incretin. Incretins are a group of gastrointestinal hormones that stimulate a decrease in blood glucose levels. GLP-1 has been shown to promote insulin production and also to decrease glucagon production. Glucagon is a peptide hormone produced by alpha cells of the pancreas that raises the concentration of glucose in the bloodstream.

References

Thank You

Lorem ipsum ad his scripta blandit partiendo, eum fastidii accumsan euripidis in, eum liber hendrerit an. Qui ut wisi vocibus suscipiantur, quo dicit ridens inciderint id. Quo mundi lobortis reformidans eu, legimus senserit definiebas an eos. Eu sit tincidunt incorrupte definitionem, vis mutat affert percipit cu, eirmod consectetuer signiferumque eu per. In usu latine equidem dolores. Quo no falli viris intellegam, ut fugit veritus placerat per.

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