Team:UNC-Chapel Hill/Project

From 2014.igem.org

(Difference between revisions)
 
(35 intermediate revisions not shown)
Line 1: Line 1:
{{CSS/Main}}
{{CSS/Main}}
 +
{{:Team:UNC-Chapel_Hill/practicemenu}}
<html>
<html>
-
<style>
+
<head>
-
#contentSub, #footer-box, #catlinks, #search-controls, #p-logo, .printfooter, .firstHeading,.visualClear {display: none;} /*-- hides default wiki settings --*/
+
<link href="https://2014.igem.org/Team:UNC-Chapel_Hill/StyleSheets/HomePage?action=raw&ctype=text/css" rel="stylesheet">
-
</style>
+
</head>
-
<!--  here ends the section that changes the default wiki template to a white full width background -->
 
-
 
-
 
-
<!-- beginning of your page -->
 
-
 
-
<!-- menu -->
 
-
<table id="menu" width="100%"  cellspacing="0" height="135px">
 
-
<tr>
 
-
<td  bgColor="#FFFFFF"></td>
 
-
<td valign="bottom"  width="975px" align="center" bgColor="#FFFFFF">
 
-
 
-
<table align="center">
 
-
<tr height="50px">
 
-
<td width="162px" align="center" onMouseOver="this.bgColor='#A1DBB2'" onMouseOut="this.bgColor='#56A0D3'" bgColor=#56A0D3>
 
-
<a href="https://2014.igem.org/Team:UNC-Chapel_Hill"style="text-decoration:none;color:#ffffff">HOME </a> </td>
 
-
 
-
<td width="162px" align="center" onMouseOver="this.bgColor='#A1DBB2'" onMouseOut="this.bgColor='#56A0D3'" bgColor=#56A0D3>
 
-
<a href="https://2014.igem.org/Team:UNC-Chapel_Hill/Project" style="text-decoration:none;color:#ffffff">PROJECT</a> </td>
 
-
 
-
<td width="162px" align="center" onMouseOver="this.bgColor='#A1DBB2'" onMouseOut="this.bgColor='#56A0D3'" bgColor=#56A0D3>
 
-
<a href="https://2014.igem.org/Team:UNC-Chapel_Hill/Parts" style="text-decoration:none;color:#ffffff">PARTS</a></td>
 
-
 
-
<td width="162px" align="center" onMouseOver="this.bgColor='#A1DBB2'" onMouseOut="this.bgColor='#56A0D3'" bgColor=#56A0D3>
 
-
<a href="https://2014.igem.org/Team:UNC-Chapel_Hill/Team" style="text-decoration:none;color:#ffffff">TEAM </a> </td>
 
-
 
-
<td width="162px" align="center" onMouseOver="this.bgColor='#A1DBB2'" onMouseOut="this.bgColor='#56A0D3'" bgColor=#56A0D3> 
 
-
<a href="https://2014.igem.org/Team:UNC-Chapel_Hill/Notebook" style="text-decoration:none;color:#ffffff">NOTEBOOK </a> </td>
 
-
 
-
<td width="162px" align="center" onMouseOver="this.bgColor='#A1DBB2'" onMouseOut="this.bgColor='#56A0D3'" bgColor=#56A0D3> 
 
-
<a href="https://2014.igem.org/Team:UNC-Chapel_Hill/Safety" style="text-decoration:none;color:#ffffff">SAFETY </a></td>
 
-
 
-
<td width="162px" align="center" onMouseOver="this.bgColor='#A1DBB2'" onMouseOut="this.bgColor='#56A0D3'" bgColor=#56A0D3>
 
-
<a href="https://2014.igem.org/Team:UNC-Chapel_Hill/Attributions" style="text-decoration:none;color:#ffffff">ATTRIBUTIONS</a></td>
 
-
 
-
</tr>
 
-
 
-
<tr> <td colspan="6"></td>
 
-
<td align="center" width="162px"><a href="https://igem.org/Main_Page"> <img src="https://static.igem.org/mediawiki/igem.org/6/60/Igemlogo_300px.png" width="55px"></a></td>
 
-
 
-
</tr>
 
-
</table>
 
-
 
-
</td>
 
-
<td  bgColor="#FFFFFF"></td>
 
-
</tr>
 
-
</table>
 
-
<!-- end of menu -->
 
<!--Project content  -->
<!--Project content  -->
Line 59: Line 13:
<!-- first block of three columns -->
<!-- first block of three columns -->
<center>
<center>
-
<table width="76%"  cellspacing="0" height="10px">
+
<table width="975"  cellspacing="0" height="10px">
-
<tr><td  bgColor="#56A0D3"></td> <td colspan="3" width="975px" bgColor="#56A0D3" align="center"> <p style="color:white;font-size:20px">FIGHTING DIABETES </p></td> <td  bgColor="#56A0D3"></td> </tr>
+
<tr><td  bgColor="#56A0D3"></td> <td colspan="3" width="975px" bgColor="#56A0D3" align="center"> <p style="color:white;font-size:20px">DIABETES MELLITUS </p></td> <td  bgColor="#56A0D3"></td> </tr>
</table>
</table>
</center>
</center>
Line 68: Line 22:
<td width="435px"  height="100px"  bgColor="#FFFFFF" >
<td width="435px"  height="100px"  bgColor="#FFFFFF" >
-
<h3>Project Introduction</h3>
+
<h3 style="color:#56A0D3; font-size:30px">Project Introduction</h3>
-
<p>Diabetes is prevalent throughout the world. As a treatable disease, diabetes has fallen in the shadow of more life threatening diseases. Although treatable, diabetes can be life threatening, especially to those who cannot afford treatment options. We propose a protein co trolled system to sense glucose concentrations and release needed proteins I hopes of creating of cost effective and accurate means of glucose sensing via E. Coli. </p>
+
<p>Diabetes mellitus is prevalent throughout the world especially in the United States and Mexico. As a treatable disease, diabetes has fallen in the shadow of more life threatening diseases. Although treatable, diabetes can be life threatening, especially to those who cannot afford treatment options. As a solution, we propose a protein controlled system to sense glucose concentrations and release the needed proteins in response. This project executes the first crucial steps of creating a cost effective and accurate means of glucose sensing via the use of Escherichia coli. </p>
</td>
</td>
<td width="50px"></td>
<td width="50px"></td>
<td width="435px" bgColor="#FFFFFF">
<td width="435px" bgColor="#FFFFFF">
-
<h4>Results</h4>
+
<h3 style="color:#56A0D3; font-size:30px">Results</h3>
-
<ul>
+
<p>
 +
<ul style="font: 18px/1.6 'Segoe UI', Calibri, Helvetica, sans-serif;
 +
margin: 4px 0 12px 0;
 +
padding-left: 20px;
 +
text-indent: 0;
 +
color: #000000;
 +
text-align:justify;
 +
text-justify:inter-word;">
<li>Result 1 - Lorem ipsum ad his scripta blandit partiendo, eum fastidii accumsan euripidis in, eum liber hendrerit an.</li>
<li>Result 1 - Lorem ipsum ad his scripta blandit partiendo, eum fastidii accumsan euripidis in, eum liber hendrerit an.</li>
<li>Result 2 - Lorem ipsum ad his scripta blandit partiendo, eum fastidii accumsan euripidis in, eum liber hendrerit an.</li>  
<li>Result 2 - Lorem ipsum ad his scripta blandit partiendo, eum fastidii accumsan euripidis in, eum liber hendrerit an.</li>  
Line 81: Line 42:
</ul>
</ul>
 +
</p>
</td>
</td>
Line 86: Line 48:
</tr>
</tr>
</table>
</table>
 +
 +
 +
<center>
 +
<table width="975"  cellspacing="0" height="115px">
 +
<tr>
 +
<td  bgColor="#FFFFFF"></td>
 +
 +
<td width="100%"  height="4px"  bgColor="#FFFFFF" >
 +
 +
<p></p>
 +
 +
<img src="https://static.igem.org/mediawiki/2014/thumb/b/b8/UNC_Chapel_Hill_Old_Well_Masthead.jpg/800px-UNC_Chapel_Hill_Old_Well_Masthead.jpg"  width="100%">
 +
 +
</td>
 +
</tr>
 +
</table>
 +
</center>
 +
 +
<!-- end of first block -->
<!-- end of first block -->
<!-- navigation for project page-->
<!-- navigation for project page-->
-
<table width="100%" align="center" >
+
<table width="1000" align="center" >
<tr>
<tr>
Line 98: Line 79:
</td>
</td>
-
<td align="center" width="10%" height ="35px"
 
-
onMouseOver="this.bgColor='#A1DBB2'" onMouseOut="this.bgColor='#56A0D3'" bgColor=#56A0D3> 
 
-
<a href="#topic1" style="text-decoration:none;color:#ffffff">Topic 1 </a> </td>
 
-
</td>
 
<td align="center" width="10%" height ="35px"  
<td align="center" width="10%" height ="35px"  
onMouseOver="this.bgColor='#A1DBB2'" onMouseOut="this.bgColor='#56A0D3'" bgColor=#56A0D3>   
onMouseOver="this.bgColor='#A1DBB2'" onMouseOut="this.bgColor='#56A0D3'" bgColor=#56A0D3>   
-
<a href="#topic2" style="text-decoration:none;color:#ffffff">Topic 2 </a> </td>
+
<a href="#type1" style="text-decoration:none;color:#ffffff">Type One </a> </td>
</td>
</td>
<td align="center" width="10%" height ="35px"  
<td align="center" width="10%" height ="35px"  
onMouseOver="this.bgColor='#A1DBB2'" onMouseOut="this.bgColor='#56A0D3'" bgColor=#56A0D3>   
onMouseOver="this.bgColor='#A1DBB2'" onMouseOut="this.bgColor='#56A0D3'" bgColor=#56A0D3>   
-
<a href="#topic3" style="text-decoration:none;color:#ffffff">Topic 3 </a> </td>
+
<a href="#type2" style="text-decoration:none;color:#ffffff">Type Two </a> </td>
</td>
</td>
Line 138: Line 115:
<td width="450px"  bgColor="#FFFFFF">
<td width="450px"  bgColor="#FFFFFF">
-
<h4 id="abstract"> Abstract</h4>
+
<p id="abstract" style="color:#56A0D3; font-size:30px"> Abstract</p>
<p>Lorem ipsum ad his scripta blandit partiendo, eum fastidii accumsan euripidis in, eum liber hendrerit an. Qui ut wisi vocibus suscipiantur, quo dicit ridens inciderint id. Quo mundi lobortis reformidans eu, legimus senserit definiebas an eos. Eu sit tincidunt incorrupte definitionem, vis mutat affert percipit cu, eirmod consectetuer signiferumque eu per. In usu latine equidem dolores. Quo no falli viris intellegam, ut fugit veritus placerat per.</p>
<p>Lorem ipsum ad his scripta blandit partiendo, eum fastidii accumsan euripidis in, eum liber hendrerit an. Qui ut wisi vocibus suscipiantur, quo dicit ridens inciderint id. Quo mundi lobortis reformidans eu, legimus senserit definiebas an eos. Eu sit tincidunt incorrupte definitionem, vis mutat affert percipit cu, eirmod consectetuer signiferumque eu per. In usu latine equidem dolores. Quo no falli viris intellegam, ut fugit veritus placerat per.</p>
</td>
</td>
<td width="20px"></td>
<td width="20px"></td>
-
<td width="450px" bgColor="#FFFFFF">
+
<td width="50px" bgColor="#FFFFFF">
-
<img src="https://static.igem.org/mediawiki/2014/c/ce/Dnastrand2.png" width="400px">
+
<a href="http://www.diabetes.org/" target="_blank"><img src="https://static.igem.org/mediawiki/2014/thumb/e/ee/UNC_Chapel_Hill_Blue_circle.png/617px-UNC_Chapel_Hill_Blue_circle.png" width="200px" align="right" ></a>
-
<p> You can place an image here about your project</p>
+
 
</td>
</td>
Line 152: Line 129:
</table>
</table>
<!-- end of first block -->
<!-- end of first block -->
-
<table width="100%"  cellspacing="0" height="230px">
 
 +
 +
 +
 +
 +
<center>
 +
<table width="975"  cellspacing="4" height="115px">
<tr>
<tr>
<td  bgColor="#FFFFFF"></td>
<td  bgColor="#FFFFFF"></td>
-
<td width="435px"  height="400px"  bgColor="#FFFFFF" >
+
<td width="100%"  height="4px"  bgColor="#FFFFFF" >
-
<h4 id="topic1"> Topic One</h4>
+
 
-
<p>Diabetes is prevalent throughout the world. As a treatable disease, diabetes has fallen in the shadow of more life threatening diseases. Although treatable, diabetes can be life threatening, especially to those who cannot afford treatment options. We propose a protein co trolled system to sense glucose concentrations and release needed proteins I hopes of creating of cost effective and accurate means of glucose sensing via E. Coli. </p>
+
<p id="type1" style="color:#56A0D3; font-size:30px"> Type One Diabetes</p>
 +
<h2 style="color:#56A0D3"> Solution </h2>
 +
<p>Type 1 diabetes is characterized by the body’s immune system destroying insulin producing cells which leads the body to no longer producing insulin, a hormone that promotes the uptake of glucose by cells. We provide a solution for this problem through the creation of a pseudo beta cell that is able to produce insulin in the presence of high glucose level. </p>
 +
 
 +
 
 +
 
</td>
</td>
 +
</tr>
 +
</table>
 +
</center>
 +
 +
<center>
 +
<table width="975"  cellspacing="4" height="115px">
 +
<tr>
 +
<td  bgColor="#FFFFFF"></td>
 +
 +
<td width="100%"  height="4px"  bgColor="#FFFFFF" >
 +
 +
<p id="type2" style="color:#56A0D3; font-size:30px"> Type Two Diabetes</p>
 +
<h2 style="color:#56A0D3"> Solution </h2>
 +
<p>Type 2 diabetes is characterized by the body being inefficient in its use of insulin (insulin resistance) which causes the pancreas to decrease insulin production (insulin deficiency). Our potential solution for this is to have pseudo L cells release GLP-1 to promote insulin production. GLP-1 is an incretin. Incretins are a group of gastrointestinal hormones that stimulate a decrease in blood glucose levels. GLP-1 has been shown to promote insulin production and also to decrease glucagon production. Glucagon is a peptide hormone produced by alpha cells of the pancreas that raises the concentration of glucose in the bloodstream.</p>
 +
-
<td width="50px"></td>
 
-
<td width="435px" bgColor="#FFFFFF">
 
-
<h4>Results</h4>
 
-
<ul>
 
-
<li>Result 1 - Lorem ipsum ad his scripta blandit partiendo, eum fastidii accumsan euripidis in, eum liber hendrerit an.</li>
 
-
<li>Result 2 - Lorem ipsum ad his scripta blandit partiendo, eum fastidii accumsan euripidis in, eum liber hendrerit an.</li>
 
-
<li>Result 3 - Lorem ipsum ad his scripta blandit partiendo, eum fastidii accumsan euripidis in, eum liber hendrerit an.</li>
 
-
</ul>
 
</td>
</td>
 +
</tr>
 +
</table>
 +
</center>
 +
<center>
 +
<table width="975"  cellspacing="4" height="115px">
 +
<tr>
<td  bgColor="#FFFFFF"></td>
<td  bgColor="#FFFFFF"></td>
 +
 +
<td width="100%"  height="4px"  bgColor="#FFFFFF" >
 +
 +
<p id="references" style="color:#56A0D3; font-size:30px"> References</p>
 +
<h2 style="color:#56A0D3"> Thank You </h2>
 +
<p>Lorem ipsum ad his scripta blandit partiendo, eum fastidii accumsan euripidis in, eum liber hendrerit an. Qui ut wisi vocibus suscipiantur, quo dicit ridens inciderint id. Quo mundi lobortis reformidans eu, legimus senserit definiebas an eos. Eu sit tincidunt incorrupte definitionem, vis mutat affert percipit cu, eirmod consectetuer signiferumque eu per. In usu latine equidem dolores. Quo no falli viris intellegam, ut fugit veritus placerat per.</p>
 +
 +
 +
 +
</td>
</tr>
</tr>
</table>
</table>
 +
</center>
 +
 +
 +
<footer>
 +
<a href="#" class="go-top">Top</a>
 +
 +
</footer>
 +
 +
</html>
</html>

Latest revision as of 02:31, 5 August 2014

DIABETES MELLITUS

Project Introduction

Diabetes mellitus is prevalent throughout the world especially in the United States and Mexico. As a treatable disease, diabetes has fallen in the shadow of more life threatening diseases. Although treatable, diabetes can be life threatening, especially to those who cannot afford treatment options. As a solution, we propose a protein controlled system to sense glucose concentrations and release the needed proteins in response. This project executes the first crucial steps of creating a cost effective and accurate means of glucose sensing via the use of Escherichia coli.

Results

  • Result 1 - Lorem ipsum ad his scripta blandit partiendo, eum fastidii accumsan euripidis in, eum liber hendrerit an.
  • Result 2 - Lorem ipsum ad his scripta blandit partiendo, eum fastidii accumsan euripidis in, eum liber hendrerit an.
  • Result 3 - Lorem ipsum ad his scripta blandit partiendo, eum fastidii accumsan euripidis in, eum liber hendrerit an.

Abstract Type One Type Two Modeling References

Abstract

Lorem ipsum ad his scripta blandit partiendo, eum fastidii accumsan euripidis in, eum liber hendrerit an. Qui ut wisi vocibus suscipiantur, quo dicit ridens inciderint id. Quo mundi lobortis reformidans eu, legimus senserit definiebas an eos. Eu sit tincidunt incorrupte definitionem, vis mutat affert percipit cu, eirmod consectetuer signiferumque eu per. In usu latine equidem dolores. Quo no falli viris intellegam, ut fugit veritus placerat per.

Type One Diabetes

Solution

Type 1 diabetes is characterized by the body’s immune system destroying insulin producing cells which leads the body to no longer producing insulin, a hormone that promotes the uptake of glucose by cells. We provide a solution for this problem through the creation of a pseudo beta cell that is able to produce insulin in the presence of high glucose level.

Type Two Diabetes

Solution

Type 2 diabetes is characterized by the body being inefficient in its use of insulin (insulin resistance) which causes the pancreas to decrease insulin production (insulin deficiency). Our potential solution for this is to have pseudo L cells release GLP-1 to promote insulin production. GLP-1 is an incretin. Incretins are a group of gastrointestinal hormones that stimulate a decrease in blood glucose levels. GLP-1 has been shown to promote insulin production and also to decrease glucagon production. Glucagon is a peptide hormone produced by alpha cells of the pancreas that raises the concentration of glucose in the bloodstream.

References

Thank You

Lorem ipsum ad his scripta blandit partiendo, eum fastidii accumsan euripidis in, eum liber hendrerit an. Qui ut wisi vocibus suscipiantur, quo dicit ridens inciderint id. Quo mundi lobortis reformidans eu, legimus senserit definiebas an eos. Eu sit tincidunt incorrupte definitionem, vis mutat affert percipit cu, eirmod consectetuer signiferumque eu per. In usu latine equidem dolores. Quo no falli viris intellegam, ut fugit veritus placerat per.