Team:UT-Tokyo

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<h1 >WELCOME TO iGEM 2014! </h1>
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<a href="https://2014.igem.org/Team:UT-Tokyo/CTCD"><img src = "https://static.igem.org/mediawiki/2014/5/52/Ctc_icon.png" id = "right-img" /></a>
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<p>Your team has been approved and you are ready to start the iGEM season!
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<br>On this page you can document your project, introduce your team members, document your progress <br> and share your iGEM experience with the rest of the world! </p>
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<p style="color:#E7E7E7"> <a href="https://2014.igem.org/wiki/index.php?title=Team:UT-Tokyo&action=edit"style="color:#FFFFFF"> Click here  to edit this page!</a> </p>
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<h2>Project Description</h2>
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<p><b style="font-size:large;">σ-Re Counter</b><br />In the field of synthetic biology, Genetic memory devices have been constructed and applied widely from Biocomputing to biomedical technologies as a crucial component. Such memory devices include a cellular counter; a fundamental device which memorizes the number of induction events. Recent efforts have resulted in a cellular counter that can count up to three events. However, this counter cannot be reset to its initial state. Here, we propose a resettable cellular counter called “sigma recounter”. This counter utilizes the regulation system of sigma factor and anti-sigma factor as the key of its resetting mechanism. In this system a set of sigma factors are designed to update and maintain a count that responds to each inducted event. By the other stimulus, the system initiates a genetic circuit that can express a suitable set of anti-sigma factors and erases the existing memory, which will enable our device to restart the count from any state.</p>
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<p><b style="font-size:large;">CTCD</b><br />Circulating Tumor cells (CTCs) are tumor cells derived from primary cancerous tissues and flowing through blood vessels. By detecting CTCs, it can be attained to find early-stage cancer. In the present efforts of detecting CTCs, markers used to distinguish CTCs from other types of cells have been restricted to cell surface proteins. On the other hand, by introducing genetic circuits into cells, we can utilize intracellular molecules such as RNAs and proteins. Here, we developed a new method focusing on both EGP-2 promoter, which is highly activated in CTCs, and miRNA, which is expressed and inhibits the translation of mRNA only in hematopoietic cells. By combining these two markers, our method would achieve detecting CTCs with high accuracy.</p>
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<a href="https://2014.igem.org/Team:UT-Tokyo"style="color:#000000">Home </a> </td>
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<a href="https://2014.igem.org/Team:UT-Tokyo/Team"style="color:#000000"> Team </a> </td>
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<a href="https://igem.org/Team.cgi?year=2014&team_name=UT-Tokyo"style="color:#000000"> Official Team Profile </a></td>
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<a href="https://2014.igem.org/Team:UT-Tokyo/Project"style="color:#000000"> Project</a></td>
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<a href="https://2014.igem.org/Team:UT-Tokyo/Modeling"style="color:#000000"> Modeling</a></td>
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<a href="https://2014.igem.org/Team:UT-Tokyo/Attributions"style="color:#000000"> Attributions </a></td>
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<p> Please be sure to keep these links, your audience will want to find your: </p>
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<li><a href="https://2014.igem.org/Team:UT-Tokyo">Home</a> </li>
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<li><a href="https://2014.igem.org/Team:UT-Tokyo/Team">Team</a> </li>
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<li><a href="https://igem.org/Team.cgi?year=2013&team_name=UT-Tokyo">Official Team Profile</a> </li>
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<li><a href="https://2014.igem.org/Team:UT-Tokyo/Project">Project</a> </li>
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<li><a href="https://2014.igem.org/Team:UT-Tokyo/Parts">Parts</a> </li>
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<li><a href="https://2014.igem.org/Team:UT-Tokyo/Modeling">Modeling</a> </li>
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<li><a href="https://2014.igem.org/Team:UT-Tokyo/Notebook">Notebook</a> </li>
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<li><a href="https://2014.igem.org/Team:UT-Tokyo/Safety">Safety</a> </li>
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<p>There are a few wiki requirements teams must follow:</p>
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<p>Visit the <a href="https://2014.igem.org/Wiki_How-To"> Wiki How To page </a> for a complete list of requirements, tips and other useful information. </p>
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<p>We are currently working on providing teams with some easy to use design templates.
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<br> In the meantime you can also view other team wikis for inspiration! Here are some very good examples</p>
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<li> <a href="https://2013.igem.org/Team:SDU-Denmark/"> 2013 SDU Denmark </a> </li>
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<li> <a href="https://2013.igem.org/Team:SYSU-China">2013 SYSU China</a> </li>
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<li> <a href="https://2013.igem.org/Team:Shenzhen_BGIC_ATCG"> 2013 Shenxhen BGIG ATCG </a></li>
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<li> <a href="https://2013.igem.org/Team:Colombia_Uniandes">2013 Colombia Unianades </a></li>
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<li> <a href="https://2013.igem.org/Team:Lethbridge">2013 Lethbridge</a></li>
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<p>For a full wiki list, you can visit <a href="https://igem.org/Team_Wikis?year=2013">iGEM 2013 web sites </a> and <a href="https://igem.org/Team_Wikis?year=2012">iGEM 2012 web sites</a>  lists. </p>
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<h2>Team Profile</h2>
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<img src="https://static.igem.org/mediawiki/2014/6/6f/DSC2819-17.jpg" width="800px" style="padding-top:10px;margin-left:100px;padding-bottom:20px;"/>
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<h2>Our Team</h2>
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<a href="https://twitter.com/UT_Tokyo" target="_blank" style="background:none;padding-right:0px;"><img src = "https://static.igem.org/mediawiki/2014/f/f3/Twitter_icon.png" class = "sns" style="margin-left:30px" onMouseover="this.src='https://static.igem.org/mediawiki/2014/7/7d/Twitter_iconon.png'" onMouseout="this.src='https://static.igem.org/mediawiki/2014/f/f3/Twitter_icon.png'"></a>
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<a href="https://www.facebook.com/IgemUtTokyo" target="_blank" style="background:none;padding-right:0px;"><img src = "https://static.igem.org/mediawiki/2014/3/3f/Facebook_icon.png" class = "sns" onMouseover="this.src='https://static.igem.org/mediawiki/2014/7/76/Facebook_iconon.png'" onMouseout="this.src='https://static.igem.org/mediawiki/2014/3/3f/Facebook_icon.png'"></a>
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<a href="https://igem.org/Team.cgi?id=1461" target="_blank"><img src = "https://static.igem.org/mediawiki/2014/f/f8/Team_icon_ut.png" class = "sns" onMouseover="this.src='https://static.igem.org/mediawiki/2014/0/05/Team_iconon.png'" onMouseout="this.src='https://static.igem.org/mediawiki/2014/f/f8/Team_icon_ut.png'"></a>
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<h2>Address</h2>
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<p>7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8654 Japan</p>
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<h2>Sponsors</h2>
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<img src="https://static.igem.org/mediawiki/2014/7/72/Promega.png" height="50px" style="padding-left:50px;float:left;">
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<img src="https://static.igem.org/mediawiki/2014/3/30/Cosmobio.png"  height="50px" style="padding-left:50px;float:left;">
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<img src="https://static.igem.org/mediawiki/2014/4/40/MBL%E3%83%AD%E3%82%B4.png" height="50px" style="padding-left:50px;float:left;">
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Latest revision as of 03:33, 18 October 2014

Project Description

σ-Re Counter
In the field of synthetic biology, Genetic memory devices have been constructed and applied widely from Biocomputing to biomedical technologies as a crucial component. Such memory devices include a cellular counter; a fundamental device which memorizes the number of induction events. Recent efforts have resulted in a cellular counter that can count up to three events. However, this counter cannot be reset to its initial state. Here, we propose a resettable cellular counter called “sigma recounter”. This counter utilizes the regulation system of sigma factor and anti-sigma factor as the key of its resetting mechanism. In this system a set of sigma factors are designed to update and maintain a count that responds to each inducted event. By the other stimulus, the system initiates a genetic circuit that can express a suitable set of anti-sigma factors and erases the existing memory, which will enable our device to restart the count from any state.

CTCD
Circulating Tumor cells (CTCs) are tumor cells derived from primary cancerous tissues and flowing through blood vessels. By detecting CTCs, it can be attained to find early-stage cancer. In the present efforts of detecting CTCs, markers used to distinguish CTCs from other types of cells have been restricted to cell surface proteins. On the other hand, by introducing genetic circuits into cells, we can utilize intracellular molecules such as RNAs and proteins. Here, we developed a new method focusing on both EGP-2 promoter, which is highly activated in CTCs, and miRNA, which is expressed and inhibits the translation of mRNA only in hematopoietic cells. By combining these two markers, our method would achieve detecting CTCs with high accuracy.

Team Profile

Our Team


Address

7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8654 Japan

Sponsors

Retrieved from "http://2014.igem.org/Team:UT-Tokyo"