Team:UMayor-Chile

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<div align="center"><a href="https://2014.igem.org/Team:UMayor-Chile" target="_blank"><img src="http://i57.tinypic.com/2e5uypz.png" border="0" alt="Image and video hosting by TinyPic"></a>
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<marquee>  <h1> <cente>  PROJECT IGEM TROY HORSE - UNIVERSIDAD MAYOR </center> </h1>              </marquee> <span style="color:#FFFFFF"> CHILE
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<p>Hello world!! We are an official team for the iGEM 2014. We are working so hard on our project TroyHorse, but we're having a really good experience
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<p style="color:#yellow"> <a href="https://2014.igem.org/wiki/index.php?title=Team:UMayor-Chile&action=edit"style="color:#FFFFFF"> Click here  to edit this page!</a> </p>
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<a href="https://2014.igem.org/Team:UMayor-Chile"style="color:#000000">Home </a> </td>
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<a href="https://2014.igem.org/Team:UMayor-Chile/Team"style="color:#000000"> Team </a> </td>
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<a href="https://igem.org/Team.cgi?year=2014&team_name=UMayor-Chile"style="color:#000000"> News and events </a></td>
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<a href="https://2014.igem.org/Team:UMayor-Chile/Modeling"style="color:#000000"> Modeling</a></td>
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<a href="https://2014.igem.org/Team:UMayor-Chile/Attributions"style="color:#000000"> Attributions </a></td>
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<h3 style="color:#ffffff;">The Cystic Fibrosis (CF)</h3>
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<p>It’s a mutation in the glycoprotein CFTR (that have a rol as a chloride channel), which affects the entire system, including the immune system. When a patient is diagnosticated with Pseudomonas aeruginosa in his lungs, it is too difficult to eradicate it. One reason of this it’s the biofilm generated by P. aerugunosa, which protects this opportunistic pathogen from any attack, including the treatments with antibiotics. Our project aims to generate a bacteria capable of weakening the biofilm breaking one of the main components of this protection: the arginate; and shutting down the communication between the Pseudomonas colonies. The E. coli is capable to use the biofilms, making it a good candidate for use as a Trojan horse. We going to test the above mentioned functions in this chassis, using in vitro biofilms.</p>
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<h3 style="color:#ffffff;">Fig 1: Construct that allows E. coli to weak Pseudomonas's biofilm.</h3>
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<h3 style="color:#ffffff;">Fig 2: Construct that allows E. coli to weak Pseudomonas's biofilm.</h3>
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<p><a href="http://es.tinypic.com?ref=2cz8xw6" target="_blank"><img src="http://i58.tinypic.com/2cz8xw6.jpg" border="0" alt="Image and video hosting by TinyPic"></a></p>
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      <div><span class="gwd-span-lh4n">E. coli Trojan horse invading biofilms</span>
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      <div><span class="gwd-span-8rot">&nbsp; The cystic fibrosis (CF) it’s a mutation in the glycoprotein CFTR (that have a rol as a chloride channel), which affects the entire system, including the immune system. When a patient is diagnosticated with Pseudomonas aeruginosa in his lungs, it is too difficult to eradicate it. One reason of this it’s the biofilm generated by P. aerugunosa, which protects this opportunistic pathogen from any attack, including the treatments with antibiotics. Our project aims to generate a bacteria capable of weakening the biofilm breaking one of the main components of this protection: the arginate; and shutting down the communication between the Pseudomonas colonies. The E. coli is capable to use the biofilms, making it a good candidate for use as a Trojan horse. We going to test the above mentioned functions in this chassis, using in vitro biofilms.</span>
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      <div class="gwd-div-x49g"><span class="gwd-span-nn9x">UMayor-Chile</span>
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Latest revision as of 00:55, 18 October 2014


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PROJECT IGEM TROY HORSE - UNIVERSIDAD MAYOR

CHILE

Hello world!! We are an official team for the iGEM 2014. We are working so hard on our project TroyHorse, but we're having a really good experience

Click here to edit this page!

Home Team News and events Project Parts Modeling Out the lab Safety Attributions

The Cystic Fibrosis (CF)

It’s a mutation in the glycoprotein CFTR (that have a rol as a chloride channel), which affects the entire system, including the immune system. When a patient is diagnosticated with Pseudomonas aeruginosa in his lungs, it is too difficult to eradicate it. One reason of this it’s the biofilm generated by P. aerugunosa, which protects this opportunistic pathogen from any attack, including the treatments with antibiotics. Our project aims to generate a bacteria capable of weakening the biofilm breaking one of the main components of this protection: the arginate; and shutting down the communication between the Pseudomonas colonies. The E. coli is capable to use the biofilms, making it a good candidate for use as a Trojan horse. We going to test the above mentioned functions in this chassis, using in vitro biofilms.

Fig 1: Construct that allows E. coli to weak Pseudomonas's biofilm.

Image and video hosting by TinyPic