Team:ITESM-CEM/Project
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<img src="https://static.igem.org/mediawiki/2014/5/52/10726723_10152823003736565_453836291_n.jpg" align="left" width="250" height="250" hspace="10" BORDER=10> | <img src="https://static.igem.org/mediawiki/2014/5/52/10726723_10152823003736565_453836291_n.jpg" align="left" width="250" height="250" hspace="10" BORDER=10> | ||
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<p style="text-align: justify; text-justify: inter-word;">Our project is to design and develop a preventive gene therapy for atherosclerosis, based on the usage of microbial enzymes. | <p style="text-align: justify; text-justify: inter-word;">Our project is to design and develop a preventive gene therapy for atherosclerosis, based on the usage of microbial enzymes. | ||
This is based on the fact that the human body is incapable to degrade or break down many substances that affect our health, these substances start to accumulate slowly and ultimately reduce our life span. How does it relate to atherosclerosis? | This is based on the fact that the human body is incapable to degrade or break down many substances that affect our health, these substances start to accumulate slowly and ultimately reduce our life span. How does it relate to atherosclerosis? | ||
The treatment would consist on the degradation of oxidized cholesterol. Three enzymes originally from Chromobacterium sp.6 and Rhodococcus jostii4, are capable of degrading the molecule of 7-ketocholesterol.5 The DNA enconding those three enzymes, will then be transfected into mammalian cells and localized within the lysozome, to ensure their degrading function. | The treatment would consist on the degradation of oxidized cholesterol. Three enzymes originally from Chromobacterium sp.6 and Rhodococcus jostii4, are capable of degrading the molecule of 7-ketocholesterol.5 The DNA enconding those three enzymes, will then be transfected into mammalian cells and localized within the lysozome, to ensure their degrading function. | ||
This project will potentially be the basis of the development of novel treatments for atherosclerosis, as well as the enzymatic tratment of food in order to remove trace amounts of 7-ketocholesterol they might contain.</p> | This project will potentially be the basis of the development of novel treatments for atherosclerosis, as well as the enzymatic tratment of food in order to remove trace amounts of 7-ketocholesterol they might contain.</p> | ||
- | <h2>References </h2> | + | <h2>References</h2> |
<p> | <p> | ||
1. Benoit C, Drouot S, Barrail-Tran A, Taburet AM. Drug-drug interactions between HMG-CoA reductase inhibitors (statins) and antiviral protease inhibitors. Clin Pharmacokinet. 2013 May 24; 52: 815-831. <br><br> | 1. Benoit C, Drouot S, Barrail-Tran A, Taburet AM. Drug-drug interactions between HMG-CoA reductase inhibitors (statins) and antiviral protease inhibitors. Clin Pharmacokinet. 2013 May 24; 52: 815-831. <br><br> |
Latest revision as of 23:43, 17 October 2014
ITESM-CEM | Enzy7-K me |
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