Team:UFMG Brazil

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                            HEADER
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                                <li><a href="#">Project</a>
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                                        <li><a href="https://2014.igem.org/Team:UFMG Brazil/Project/Intro">Introduction</a></li>
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                                        <li><a href="https://2014.igem.org/Team:UFMG_Brazil/Project/Parts">Parts</a></li>
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                                        <li><a href="https://2014.igem.org/Team:UFMG_Brazil/Project/Protocols">Protocols and results</a></li>
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                                        <li><a href="https://2014.igem.org/Team:UFMG_Brazil/Project/Modelling">Modelling</a></li>
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                                        <li><a href="https://2014.igem.org/Team:UFMG_Brazil/Project/Notebook">Notebook</a></li>
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                                </li>
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                                <li><a href="#">Thanks to</a>
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                                        <a href="https://2014.igem.org/Team:UFMG_Brazil/sponsors">Sponsors</a>
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                                        <a href="https://2014.igem.org/Team:UFMG_Brazil/attributions">Attributions</a>
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                      <div class="title1">- Team UFMG Brazil presents -</div>
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                    </div>
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                    <div class="slogan">How to stop a war<br>before it starts?</div>
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                    <div class="unit" style="padding-top:10px;">
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                      <div class="" style="padding-bottom:10px;"><img src="https://static.igem.org/mediawiki/2014/7/77/Logooverlay.png" alt=""></div>
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                      <div class="title1">Come closer and discover</div>
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                      <div class="title2" style="color: #eae6e3;">The Colon Yeast</div>
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                      <div>
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                          <p style="padding-top: 28px;">The hemiCherry in the (FAECAL) Cake</p>
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                          <img src="https://static.igem.org/mediawiki/2014/4/4b/Cherry1.png" alt="">
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                        </div>
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                      <!--
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                      <p><time datetime="2014-01-11">wednesday, may 28</time>
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                      &nbsp;|&nbsp;Winning Numbers:</p>
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                      <ul class="list">
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                          <li>19</li>
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                          <li>24</li>
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                          <li>45</li>
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                          <li>18</li>
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                          <li>36</li>
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                          <li>5</li>
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                      </ul>
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                      <div class="ticket">
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                          <a href="#">see current winning <br>ticket results</a>
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                      </div>
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                        -->
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                            CONTENT
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<h1 >WIKI UNDER CONSTRUCTION</h1>
 
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<p>Hello guys!! This year our team are proposing a project for another serious disease that thousands of people are
 
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  affected every year in the whole world:<br>
 
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  We intend to help in the colon cancer diagnosis!
 
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<br>
 
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</p>
 
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<p style="color:#E7E7E7"> <a href="https://2014.igem.org/wiki/index.php?title=Team:UFMG_Brazil&action=edit"style="color:#FFFFFF"> Click here  to edit this page!</a> </p>
 
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                            <h3>So, how to stop a war before it started?</h3>
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                            <br>
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                            <p style="text-transform: none;"><span>Colorectal cancer includes tumors affecting a segment of the large intestine (colon) and rectum. It is treatable and, in most cases, curable when detected early, before it hasn't spread to other organs. <br><br>However, the diagnosis requires a biopsy, made ​​by handset introduced via rectum. Noticeably, this procedure is highly invasive and often inhibits patients to submit to this practice, hampering the discovery of cancer at an early stage and thereby reducing the chances of effective treatment and cure. On our institution, a modified probiotic strain of Saccharomyces cerevisiae was isolated from local beverage.<br><br>Our objective is to introduce this strain as a new probiotic chassis on iGEM, and also to develop a gene circuit that allows it to detect one or more stool biomarkers for colorectal cancer on the intestine and report with a color change on the feces. We chose L-DNA (long DNA molecules) as biomarker, and designed a chimeric protein using TALE DNA-Binding Domains and a split version of mCherry.<br><br> This protein can detect certain repetitive sequences on DNA and emit red fluorescence, which when measured serve as proxy for the DNA size. Since RFP emission falls on the visible spectrum, it can also be used for staining the feces, allowing for a patient consuming the probiotic to become aware of the possibility of the developing problem just by checking on the color of their stool.</span></p>
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                        <div class="image" style="left: -54px;">
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                            <img src="images/redyeast.png" alt="">
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                            <h2>Believe in your win! <span>Good luck!</span></h2>
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                            <div class="grid_4 alpha">
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                                <a href="#" class="link1">How To Play</a>
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                                <p>Praesent vestibulum aenean nonummy hendrerit mauris. Hasellus porta. Fusce suscipit varius mi. Cum sociis atoque penatibus magnis dis parturient montes nascetur ridiculus mus.</p>
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                                <ul class="links">
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                                    <li><a href="#" class="col1">for <br>players</a>
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                                    </li>
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                                    <li><a href="#" class="col2">for <br>retailers</a>
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                                    </li>
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                                    <li><a href="#" class="col3">message <br>center</a>
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<a href="https://2014.igem.org/Team:UFMG_Brazil/Team"style="color:#000000"> Team </a> </td>
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                        <h2>latest winners:</h2>
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                    </div>
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                </div>
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                                      <a href="#" title="">Richard Clark</a>
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                                      <p>Won $1.000 <span>playing <br>$1000 overload</span></p>
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                                  </div>
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                                  <div class="caption">
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                                      <a href="#" title="">Tamara Smith</a>
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                                      <p>Won $1.000 <span>playing <br>$1000 overload</span></p>
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                                  </div>
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                                      <a href="#" title="">Linda Nelson</a>
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                                      <p>Won $1.000 <span>playing <br>$1000 overload</span></p>
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                                  </div>
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                                      <a href="#" title="">George Johnson</a>
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                                      <p>Won $1.000 <span>playing <br>$1000 overload</span></p>
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                                  </div>
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                              </div>
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                                      <a href="#" title="">Richard Clark</a>
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                                      <p>Won $1.000 <span>playing <br>$1000 overload</span></p>
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                                  </div>
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                                      <a href="#" title="">Tamara Smith</a>
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                                      <p>Won $1.000 <span>playing <br>$1000 overload</span></p>
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                                  </div>
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<a href="https://igem.org/Team.cgi?year=2014&team_name=UFMG_Brazil"style="color:#000000"> Official Team Profile </a></td>
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<a href="https://2014.igem.org/Team:UFMG_Brazil/Project"style="color:#000000"> Project</a></td>
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                        <h4>We are from Brazil!</h4>
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                        <p>aaa aaa</p>
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  =========================================================-->
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<td style="border:1px solid black;" align="center" height ="45px" onMouseOver="this.bgColor='#d3d3d3'" onMouseOut="this.bgColor='#e7e7e7'" bgColor=#e7e7e7>  
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<a href="https://2014.igem.org/Team:UFMG_Brazil/Modeling"style="color:#000000"> Modeling</a></td>
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      <div class="container">
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          <div class="row">
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              <div class="grid_12">
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                  <a class="logo1" href="https://2014.igem.org/Team:UFMG_Brazil">
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                    <img src="https://static.igem.org/mediawiki/2014/8/84/Yeastlogo_small_gray.png" alt="">
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                  </a>
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                  <div class="copy">
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                      <span>&nbsp;&copy;</span>
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                      <span id="copyright-year"></span>
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                      <span>|</span>
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                      <span><a href="https://2014.igem.org/Team:UFMG_Brazil">Team UFMG Brazil</a></span>
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        $(document).ready(function() {
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            $("#owl").owlCarousel({
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                items: 4,
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                itemsDesktop: [1299, 4],
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                itemsTablet: [995, 3],
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                itemsTabletSmall: [767, 1],
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                itemsMobile: [479, 1],
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                lazyLoad: true,
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                pagination: false,
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        $( document ).ready(function() {
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          $('#topmenutoggle').click(function(){
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            toggleMenu();
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        });
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          if($('#top-section').css("height") == "25px"){
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              $('#top-section').css("height", "10px");
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              $('.left-menu').hide();
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              $('.right-menu').hide();
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          }
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          else{
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              $('#top-section').css("height", "25px");
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              $('.left-menu').show();
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              $('.right-menu').show();
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<td style="border:1px solid black;" align="center"  height ="45px" onMouseOver="this.bgColor='#d3d3d3'" onMouseOut="this.bgColor='#e7e7e7'" bgColor=#e7e7e7>
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    <a style="margin-right: -49px; right: 50%; display: none;" href="#" id="toTop" class="fa fa-chevron-up"></a>
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<a href="https://2014.igem.org/Team:UFMG_Brazil/Attributions"style="color:#000000"> Attributions </a></td>
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<td align ="center"><a href="https://2014.igem.org/Main_Page"><img src="https://static.igem.org/mediawiki/2014/b/b4/Igem_rodando.gif" width="82" height="65"></a></td>
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<p> Please be sure to keep these links, your audience will want to find your: </p>
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<!-- Links to other team pages -->
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<ul>
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<li><a href="https://2014.igem.org/Team:UFMG_Brazil">Home</a> </li>
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<li><a href="https://2014.igem.org/Team:UFMG_Brazil/Team">Team</a> </li>
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<li><a href="https://igem.org/Team.cgi?year=2013&team_name=UFMG_Brazil">Official Team Profile</a> </li>
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<li><a href="https://2014.igem.org/Team:UFMG_Brazil/Project">Project</a> </li>
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<li><a href="https://2014.igem.org/Team:UFMG_Brazil/Parts">Parts</a> </li>
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<li><a href="https://2014.igem.org/Team:UFMG_Brazil/Modeling">Modeling</a> </li>
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<li><a href="https://2014.igem.org/Team:UFMG_Brazil/Notebook">Notebook</a> </li>
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<li><a href="https://2014.igem.org/Team:UFMG_Brazil/Safety">Safety</a> </li>
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<p>There are a few wiki requirements teams must follow:</p>
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<li>All pages must be created under the team’s name space.</li>
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<li>As part of your documentation, keep the links from the menu to the left. </li>
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<li>The <a href="https://static.igem.org/mediawiki/igem.org/6/60/Igemlogo_300px.png"> iGEM logo </a> should be placed on the upper part of every page and should link to <a href="https://2014.igem.org/Main_Page">2014.igem.org</a>.</li>
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<p>Visit the <a href="https://2014.igem.org/Wiki_How-To"> Wiki How To page </a> for a complete list of requirements, tips and other useful information. </p>
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<p>We are currently working on providing teams with some easy to use design templates.
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<li> <a href="https://2013.igem.org/Team:SDU-Denmark/"> 2013 SDU Denmark </a> </li>
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<li> <a href="https://2013.igem.org/Team:SYSU-China">2013 SYSU China</a> </li>
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<li> <a href="https://2013.igem.org/Team:Shenzhen_BGIC_ATCG"> 2013 Shenxhen BGIG ATCG </a></li>
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<li> <a href="https://2013.igem.org/Team:Colombia_Uniandes">2013 Colombia Unianades </a></li>
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<li> <a href="https://2013.igem.org/Team:Lethbridge">2013 Lethbridge</a></li>
+
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<p>For a full wiki list, you can visit <a href="https://igem.org/Team_Wikis?year=2013">iGEM 2013 web sites </a> and <a href="https://igem.org/Team_Wikis?year=2012">iGEM 2012 web sites</a>  lists. </p>
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<p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p>
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<li>State your accomplishments! Tell people what you have achieved from the start. </li>
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<li>Be clear about what you are doing and what you plan to do.</li>
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<li>You have a global audience! Consider the different backgrounds that your users come from.</li>
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<li>Make sure information is easy to find; nothing should be more than 3 clicks away.  </li>
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<li>Avoid using very small fonts and low contrast colors; information should be easy to read.  </li>
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<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="">iGEM 2013 calendar</a> </li>
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<li>Have lots of fun! </li>
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Latest revision as of 17:44, 14 June 2015

Home UFMG Team

So, how to stop a war before it started?


Colorectal cancer includes tumors affecting a segment of the large intestine (colon) and rectum. It is treatable and, in most cases, curable when detected early, before it hasn't spread to other organs.

However, the diagnosis requires a biopsy, made ​​by handset introduced via rectum. Noticeably, this procedure is highly invasive and often inhibits patients to submit to this practice, hampering the discovery of cancer at an early stage and thereby reducing the chances of effective treatment and cure. On our institution, a modified probiotic strain of Saccharomyces cerevisiae was isolated from local beverage.

Our objective is to introduce this strain as a new probiotic chassis on iGEM, and also to develop a gene circuit that allows it to detect one or more stool biomarkers for colorectal cancer on the intestine and report with a color change on the feces. We chose L-DNA (long DNA molecules) as biomarker, and designed a chimeric protein using TALE DNA-Binding Domains and a split version of mCherry.

This protein can detect certain repetitive sequences on DNA and emit red fluorescence, which when measured serve as proxy for the DNA size. Since RFP emission falls on the visible spectrum, it can also be used for staining the feces, allowing for a patient consuming the probiotic to become aware of the possibility of the developing problem just by checking on the color of their stool.

We are from Brazil!

aaa aaa

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