Team:MIT

From 2014.igem.org

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<tr><td><h3 style="font-size:20px; color:teal" align=center><b>IMPROVING THE DIAGNOSIS AND TREATMENT OF</u></h3></td></tr>
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<tr><td><h3 style="font-size:50px; color:teal" align=center><b>ALZHEIMER'S DISEASE</b></h3></td></tr>
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<td width=33.3%>[Dying Neuron]<br>Neurodegenerative Disease</td>
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<td width=33.3%><img src="https://static.igem.org/mediawiki/2014/6/6b/MIT_homepage_dying_neuron.png"></td>
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<td width=33.3%>[6th]<br>Leading cause of death in the US</td>
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<td width=33.3%><img src="https://static.igem.org/mediawiki/2014/e/e4/MIT_homepage_sixth.png"></td>
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<td width=33.3%>[Vaccine]<br>Current diagnosis and therapeutics are not effective</td>
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<td width=33.3%><img src="https://static.igem.org/mediawiki/2014/4/44/MIT_hompage_vaccine.png"></td>
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<td width=33.3%><p style="font-size:12px; color:teal" align=top><b> NEURODEGENERATIVE <br>DISEASE </b></p></td>
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<td width=33.3%><p style="font-size:12px; color:teal"><b> 6th LEADING CAUSE OF<br> DEATH IN THE U.S.</b></p></td>
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<td width=33.3%><p style="font-size:12px; color:teal"><b> CURRENT DIAGNOSTICS AND<br> THERAPEUTICS ARE INEFFECTIVE</b></p></td>
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Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by memory loss, behavioral problems… There is currently no cure for this disease, and existing diagnosis methods leave much to be desired.  MIT iGEM 2014 has set out to change this.  By detecting molecular biomarkers for AD, such as miRNAs and neurotoxic beta-amyloid plaques, and by regulating the production of beta-amyloid plaques, MIT iGEM hopes to create a dynamic solution for patients with Alzheimer’s disease. Looking ahead, … delivery.<br>
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DETECT → TREAT → DELIVER
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<tr><td><br><p style="font-size:15px" align=left><b>Alzheimer's disease is the sixth leading cause of death</b> in the United States, affecting more than 5 million Americans and resulting in the deaths of 500,000 people every year (Alzheimer's Association). Though one in three seniors dies with this disease (Alzheimer's Association), it currently has no cure, and, according to the clinicians that we interviewed, existing diagnosis methods are unreliable.  <b>MIT iGEM 2014 is working to change this situation.</b> We set out to devise a way to diagnose Alzheimer's disease using biological rather than psychological tests and to invent a treatment mechanism that would capitalize on recent findings about the molecular pathology of the disease.  Using the principles of synthetic biology, we designed a system that <b>detects molecular biomarkers</b> for Alzheimer's disease and <b>alters the levels of key enzymes</b> in response.  Our dynamic system combats Alzheimer's disease only when the disease is detected, providing a specific, state-sensitive treatment. In the future, an approach like ours could provide a solution for patients suffering from the debilitating effects of Alzheimer's disease and improve the lives of their caretakers and family.
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<tr><td colspan=3>Detection</td>
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<tr><td colspan=3><h3 style="font-size:25px; color:teal">DETECTION</h3></td>
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<td width=33.3%>[LilRB2/PirB]<br>Natural AB receptor</td>
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<td width=33.3%>[BCR]<br>Engineered AB receptor</td>
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<td width=33.3%><a href="https://2014.igem.org/Team:MIT/Protein_sensor"><img src="https://static.igem.org/mediawiki/2014/e/e9/MIT_Native_receptor_homepage.png"><br><p style="font-size:12px; color:black"><b>NATIVE β-AMYLOID RECEPTOR</b></p></a></td>
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<td width=33.3%>[miRNA]<br>Sensors for Alzheimer’s state</td>
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<td width=33.3%><a href="https://2014.igem.org/Team:MIT/BCR"><img src="https://static.igem.org/mediawiki/2014/f/f8/MIT_bcr_homepage.png"><br><p style="font-size:12px; color:black"><b>ENGINEERED B-CELL RECEPTOR</b></p></a></td>
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<td width=33.3%><a href="https://2014.igem.org/Team:MIT/miRNA"><img src="https://static.igem.org/mediawiki/2014/8/88/MIT_mirna_homepage.png"><br><p style="font-size:12px; color:black"><b>miRNA DETECTION</b></p></a></td>
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TREATMENT<br>
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[APP]<br>
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Regulate AB production<br>
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<tr><td><h3 style="font-size:23.5px; color:teal">TREATMENT</h3></td>
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and degredation<br>
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<td><h3 style="font-size:23.5px; color:teal">DELIVERY</h3></td>
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<tr><td colspan=2>Future</td>
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<td width=50%>[Virus]<br>Ways to deliver our circuit</td>
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<td width=50%><a href="https://2014.igem.org/Team:MIT/Treatment"><img src="https://static.igem.org/mediawiki/2014/1/19/MIT_treatment_homepage.png"></a></td>
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<td width=50%>[Survey]<br>Public Opinion Survey</td>
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<td width=50%><a href="https://2014.igem.org/Team:MIT/Delivery"><img src="https://static.igem.org/mediawiki/2014/0/06/MIT_future_homepage.png"></a></td>
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<tr><td><a href="https://2014.igem.org/Team:MIT/Treatment"><p style="font-size:12px; color:black"><b>REGULATING β-AMYLOID PRODUCTION<br>AND DEGRADATION</b></p></a></td>
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<td><a href="https://2014.igem.org/Team:MIT/Delivery"><p style="font-size:12px; color:black"><b>DELIVERING THE CIRCUIT</b></p></a></td>
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<tr><td><p style="font-size:12px" align=center><i>Attributions: Kathryn Brink, Alexa Garcia, Shinjini Saha<br>Kathryn Brink (Content), Alexa Garcia (Content), Shinjini Saha (Illustrations)<br> Special mention: Shinjini Saha (Illustrations for entire website)</i></p></td></tr>
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Latest revision as of 03:54, 18 October 2014

 


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IMPROVING THE DIAGNOSIS AND TREATMENT OF

ALZHEIMER'S DISEASE


NEURODEGENERATIVE
DISEASE

6th LEADING CAUSE OF
DEATH IN THE U.S.

CURRENT DIAGNOSTICS AND
THERAPEUTICS ARE INEFFECTIVE



Alzheimer's disease is the sixth leading cause of death in the United States, affecting more than 5 million Americans and resulting in the deaths of 500,000 people every year (Alzheimer's Association). Though one in three seniors dies with this disease (Alzheimer's Association), it currently has no cure, and, according to the clinicians that we interviewed, existing diagnosis methods are unreliable. MIT iGEM 2014 is working to change this situation. We set out to devise a way to diagnose Alzheimer's disease using biological rather than psychological tests and to invent a treatment mechanism that would capitalize on recent findings about the molecular pathology of the disease. Using the principles of synthetic biology, we designed a system that detects molecular biomarkers for Alzheimer's disease and alters the levels of key enzymes in response. Our dynamic system combats Alzheimer's disease only when the disease is detected, providing a specific, state-sensitive treatment. In the future, an approach like ours could provide a solution for patients suffering from the debilitating effects of Alzheimer's disease and improve the lives of their caretakers and family.





DETECTION

NATIVE β-AMYLOID RECEPTOR

ENGINEERED B-CELL RECEPTOR

miRNA DETECTION


TREATMENT

DELIVERY

REGULATING β-AMYLOID PRODUCTION
AND DEGRADATION

DELIVERING THE CIRCUIT

Attributions: Kathryn Brink, Alexa Garcia, Shinjini Saha
Kathryn Brink (Content), Alexa Garcia (Content), Shinjini Saha (Illustrations)
Special mention: Shinjini Saha (Illustrations for entire website)

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