Team:INSA-Lyon/Modeling

From 2014.igem.org

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Latest revision as of 01:13, 18 October 2014

Curly'on - IGEM 2014 INSA-LYON

MODELING

MODELING
SUMMARY

MOLECULAR
MODELISATION

CURLI
SYNTHESIS

What is modeling?

Modeling is building and using a model. What is a model then? It is a theoretical way to explain a phenomenon in a simpler fashion than the real thing. It consists in observing a problem or a phenomenon, identifying what parameters may influence it and sorting them out so that only the most important ones are kept, and finally find out how they are related. With this, you are able to explain what happens accurately enough to be able to predict what would happen under different conditions. As such, it can take many shapes. Here are some examples of models:

Mathematical equations	Widely spread, it enables to model anything !	Ugh! No thank you...
Numerical simulations	Sometimes easier to use, but there may not exist a program yet for what you want to model...	I'm not really good with computers. ^^"
Drawings and outlines	A plain drawing is often enough to explain the processes behind a given mechanism without explaining what is happening at every level, especially in biology !	OH ! I know this one !

CurLy'on team's modeling work

As very little literature exists about curli models, especially about their structure, this year we chose to work along two directions:

we studied a molecular model of the curlin elementary subunit, CsgA, and it's engineered form;
we developed both a mathematical model describing the polymerization of CsgA, and a simulation program of the same phenomenon ; our aim was for those two models to serve as a basis for future teams working with curli.

@@ Line 13: / Line 13: @@
 			<div id="icones">
 				<ul>
+	<a href="https://2014.igem.org/Team:INSA-Lyon/Modeling" class="hu-icon"><li class="iconmulti">MODELING</br>SUMMARY</li></a>
 	<a href="https://2014.igem.org/Team:INSA-Lyon/Molecular" class="hu-icon"><li class="iconmulti">MOLECULAR</br>MODELISATION</li></a>
-	<a href="https://2014.igem.org/Team:INSA-Lyon/CurlySynthesis" class="hu-icon"><li class="iconmulti">CURLI</br>SYNTHESIS</li></a>
+	<a href="https://2014.igem.org/Team:INSA-Lyon/CurliSynthesis" class="hu-icon"><li class="iconmulti">CURLI</br>SYNTHESIS</li></a>
 				</ul>
 			</div>
@@ Line 23: / Line 24: @@
 <h6 align="left">What is modeling?</h6>
-			<div align="justify"><p>Modeling is building and using a model. What is a model then? It is a theoretical way to explain a phenomenon in a simpler fashion than the real thing. It is observing a problem or a phenomenon, identifying what parameters may influence it and sort them out so that only the most important ones are kept, and finally finding out how they are related, in order to explain what happens accurately enough to be able to predict what would happen under different conditions. As such, it can take many shapes. Here are some examples of models: </p></div>
+			<div align="justify"><p>Modeling is building and using a model. What is a model then? It is a theoretical way to explain a phenomenon in a simpler fashion than the real thing. It consists in observing a problem or a phenomenon, identifying what parameters may influence it and sorting them out so that only the most important ones are kept, and finally find out how they are related. With this, you are able to explain what happens accurately enough to be able to predict what would happen under different conditions. As such, it can take many shapes. Here are some examples of models: </p></div>
@@ Line 33: / Line 34: @@
 <tr>
    <td>Mathematical equations</td>
-   <td><div align="justify">Widely spread, it enables one to modelise about anything !</div> </td>
+   <td><div align="justify">Widely spread, it enables to model anything !</div> </td>
    <td><div align="center"><img src="https://static.igem.org/mediawiki/2014/a/a7/CurlyonEquaDiffeq1.png" alt="graphe de l'equation" width="325px"/></div></td>
    <td><i>Ugh! No thank you...</i></td>
@@ Line 39: / Line 40: @@
 <tr>
    <td>Numerical simulations</td>
-   <td><div align="justify">Sometimes easier to use, but there may not exist a program yet for what you want to modelise...</div></td>
+   <td><div align="justify">Sometimes easier to use, but there may not exist a program yet for what you want to model...</div></td>
    <td><div align="center"><img src="https://static.igem.org/mediawiki/2014/4/45/WtFace1.jpg" alt="CsgAWTSybyl" width="280px"/></div></td>
    <td><i>I'm not really good with computers. ^^"</td>
@@ Line 45: / Line 46: @@
 <tr>
    <td>Drawings and outlines</td>
-   <td><div align="justify">A plain drawing is often enough to explain the processes behind a given mechanism without explaining what is happening at every levels, especially in biology !</div></td>
+   <td><div align="justify">A plain drawing is often enough to explain the processes behind a given mechanism without explaining what is happening at every level, especially in biology !</br></div></td>
    <td><div align="center"><img src="https://static.igem.org/mediawiki/2014/a/af/CurlyonMitosis.png" alt="schema mitose" width="300px"/></div></td>
    <td><i>OH ! I know this one !</i></td>
@@ Line 51: / Line 52: @@
 </table>
+</br>
+</br>
 <h6 align="left">CurLy'on team's modeling work</h6>
-<p><div align="justify"> As very little litterature exists about curli models, especially about it's structure, this year we chose to work along two directions:
+<p><div align="justify"> As very little literature exists about curli models, especially about their structure, this year we chose to work along two directions:
 <ol>
 <li> we studied a molecular model of the curlin elementary subunit, CsgA, and it's engineered form;
-<li> we developped both a mathematical model describing the polymerisation of CsgA, and a simulation program of the same phenomenon ; our aim was for those two models to serve as a basis for future teams working with curli.
+<li> we developed both a mathematical model describing the polymerization of CsgA, and a simulation program of the same phenomenon ; our aim was for those two models to serve as a basis for future teams working with curli.
 </ol>
+</br>
+</br>
 </div></p>