Team:TU Delft-Leiden/Achievements

From 2014.igem.org

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<h2> iGEM 2014 Microfluidics  Track</h2>
<h2> iGEM 2014 Microfluidics  Track</h2>
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<h3>Bronze Medal</h3>
<h3>Bronze Medal</h3>
<ul style="list-style-type:disc">
<ul style="list-style-type:disc">
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   <li><a href="https://2014.igem.org/Team:TU_Delft-Leiden">Team Wiki</a></li>
   <li><a href="https://2014.igem.org/Team:TU_Delft-Leiden">Team Wiki</a></li>
   <li>Poster and talk for the iGEM Giant Jamboree ready</li>
   <li>Poster and talk for the iGEM Giant Jamboree ready</li>
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   <li>Demonstration of the implementation of any fluidic system. Document via video, images, and text how our team fabricated and tested any milli-, micro- or nano-fluidic system. The system documentation include both the fluidic device and any hardware for controlling the device (e.g. syringe pump). We provide evidence that (a) at least one system was fabricated, and (b) at least one aspect of the system (e.g. flow of food color) functions as planned> </li>
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   <li><a href="https://2014.igem.org/Team:TU_Delft-Leiden/Project/Microfluidics">Demonstration of the implementation of any fluidic system</a>. Our team documented via video, images, and text how we fabricated and tested any milli-, micro- or nano-fluidic system. The system documentation includes both the fluidic device and any hardware for controlling the device. We provide evidence that (a) at least one system was fabricated, and (b) at least one aspect of the system functions as planned. </li>
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<h3>Silver Medal</h3>
<h3>Silver Medal</h3>
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<p> In addition to these, our team achieved the following goals that qualify us for a silver medal: </p>
<ul style="list-style-type:disc">
<ul style="list-style-type:disc">
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  <li><a href="https://igem.org/Team.cgi">Team registration</a></li>
 
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  <li><a href="https://igem.org/2014_Judging_Form?id=1316">Complete Judging form</a></li>
 
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  <li><a href="https://2014.igem.org/Team:TU_Delft-Leiden">Team Wiki</a></li>
 
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  <li>Poster and talk for the iGEM Giant Jamboree ready</li>
 
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  <li>Demonstration of the implementation of any fluidic system. Document via video, images, and text how our team fabricated and tested any milli-, micro- or nano-fluidic system. The system documentation include both the fluidic device and any hardware for controlling the device (e.g. syringe pump). We provide evidence that (a) at least one system was fabricated, and (b) at least one aspect of the system (e.g. flow of food color) functions as planned> </li>
 
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<li> Our team documented and submited our fluidic system to the "Metafluidics" repository of device and hardware designs.<li>
 
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<li> Our team included attributions to all experts and stakeholders consulted.<li>
 
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  <li><a href="https://2014.igem.org/Team:TU_Delft-Leiden/Project/Microfluidics">Our team has demonstrated the implementation of a novel fluidic system</a></li>
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<li>Our team has <a href="https://2014.igem.org/Team:TU_Delft-Leiden/Project/Microfluidics"> documented</a> what we consider novel features compared to previous work. We also used an existing fluidic system to miniaturize an established biological process and characterize an existing Part or Device. Next, we have documented any biological protocols performed utilizing our fluidic system.</li>
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<h3>Gold Medal</h3>
<h3>Gold Medal</h3>
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<p> In addition to the Bronze and Silver Medal requirements, our team achieved the following goals, that qualify us for a gold medal:</p>
<ul style="list-style-type:disc">
<ul style="list-style-type:disc">
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  <li>Our team improved the function of an existing BioBrick Part or Device, entered this information in the Registry, created a new registry page for the improved part, and submitted this part to the iGEM Parts Registry.</li>
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<li>Utilizing our novel fluidic system, we have <a href="https://2014.igem.org/Team:TU_Delft-Leiden/Project/Life_science/EET/characterisation">characterized</a> the function of an existing Part. Any biological protocols performed utilizing our microfluidic system are documented. We compared biological protocols conducted on-chip against standard bench top techniques.  Data collected is uploaded to the page of the part(s) used on the Registry of Standard Biological Parts via experience page/contribution system.</li>   
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  <li>Our team helped another registered iGEM teams from another institution by characterizing a part and collaborated with other registered iGEM teams.</li>
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   <li>In our to address all the ethical and safety concerns related to our project (ie. Bringing synthetic biology outside the lab, the possibility that a microbial sensor device that detects landmines would be used by the wrong persons) </li>
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<h2> Medal Fulfillment </h2>
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<li>Utilizing the fluidic system, we have characterized the following new Parts:
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<h3>Bronze Medal</h3>
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<a href="http://parts.igem.org/Part:BBa_K1316011">BBa_K1316011</a> </li>
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<ul style="list-style-type:disc">
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<li><a href="http://parts.igem.org/Part:BBa_K1316012">BBa_K1316012</a> </li>
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  <li><a href="https://igem.org/Team.cgi">Team registration</a></li>
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<li><a href="http://parts.igem.org/Part:BBa_K1316016">BBa_K1316016</a>.</li>
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  <li><a href="https://igem.org/2014_Judging_Form?id=1316">Complete Judging form</a></li>
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  <li><a href="https://2014.igem.org/Team:TU_Delft-Leiden">Team Wiki</a></li>
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  <li>Poster and talk for the iGEM Giant Jamboree ready</li>
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  <li>Our team built, characterized and documented several new and existing <a href="https://2014.igem.org/Team:TU_Delft-Leiden/Project/Parts"> BioBrick parts</a></li>
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  <li><a href="https://2014.igem.org/Team:TU_Delft-Leiden/Attributions">Attributions</a> and <a href="https://2014.igem.org/Team:TU_Delft-Leiden/Acknowledgments">Acknowledgments</a> well defined</li>
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<li>Our team <a href="https://2014.igem.org/Team:TU_Delft-Leiden/Collaborations">helped</a> other registered iGEM teams from other institutions by characterizing a part and collaborated with other registered iGEM teams.</li>
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<h3>Silver Medal</h3>
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   <li>During the summer we addressed several ethical concerns related to our project, eg. bringing synthetic biology outside the lab, the possibility that a microbial sensor device that detects landmines can get into the wrong hands and safety issues. To answer all these questions, we had meetings with various stakeholders. All these aspects are well documented on our <a href="https://2014.igem.org/Team:TU_Delft-Leiden/Human_Practices">Policy&Practice page</a></li>.
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<ul style="list-style-type:disc">
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  <li>Our team experimentally validated that several new BioBrick Parts or Devices of our own design and construction work as expected</li>
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  <li>Our team documented the characterization of those parts in the "Main Page" sections of those Parts/Devices Registry entries</li>
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<li>Our team submitted those new parts to the iGEM Parts Registry adhering to the iGEM Registry guidelines</li>
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   <li>During the work on our project we raised several questions related to ethics and security. These could be found under our Safety and Policy& Practices section</li>
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<h3>iGEM Special Prizes</h3>
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<h3>Gold Medal</h3>
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<p> Our team has additional achievements that make it eligible for the following prizes:</p>
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<ul style="list-style-type:disc">
<ul style="list-style-type:disc">
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  <li>Our team improved the function of an existing BioBrick Part or Device, entered this information in the Registry, created a new registry page for the improved part, and submitted this part to the iGEM Parts Registry.</li>
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<li> <b><a href="https://2014.igem.org/Team:TU_Delft-Leiden/Modeling">Best Model</a></b>: For the conductive curli module, we wanted to know if a conductive path between two electrodes of a chip filled with curli growing <i> E. coli </i> arise at a certain point in time. We also wanted to make quantitative predictions about the resistance between the two electrodes of our system in time. We used a stochastic modeling approach, and considered the system at the gene, cell and colony level. At the colony levvel, we employed percolation theory in order to predict if a conductive path between the two electrodes arise at a certain point in time and to predict at which time this happens. Our application of percolation theory to describe the formation of a conductive biological network represents a novel approach that has not been used in the literature before. </li>
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  <li>Our team helped another registered iGEM teams from another institution by characterizing a part and collaborated with other registered iGEM teams.</li>
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<li><b><a href="https://2014.igem.org/Team:TU_Delft-Leiden/Human_Practices">Best Policy&Practice</a></b>: By interviewing and discussing with a broad range of stakeholders, we have been able to determine the best application for our landmine detection module. Besides that, we have identified various issues concerning SynBio commercialization, such as legislature and public opinion, focused on the Netherlands, and proposed a strategy to guarantee a successful future for SynBio.</li>  
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  <li>In our to address all the ethical and safety concerns related to our project (ie. Bringing synthetic biology outside the lab, the possibility that a microbial sensor device that detects landmines would be used by the wrong persons) </li>
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<li><b><a href="https://2014.igem.org/Team:TU_Delft-Leiden/Project/Life_science/EET/characterisation">Best Measurement Approach</a></b>: We measured the current our modified <i>E. coli</i> generated via a selfmade anaerobic bioreactor setup coupled to a potentiostat in order to be able to measure current created by modified <i>E. coli</i>. Subsequently, we miniaturized our potentiostat system, creating a microfluidics device (an improved version of the Dropsens). </li>
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<li><b><a href="https://2014.igem.org/Team:TU_Delft-Leiden/Project/Gadget">Best Supporting Software</a></b>: We wrote code for Labview in order to be able to perform the relevant measurements for our potentiostat setup. This code can be used by others to perform these measurements as well.</li>  
</ul>
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Latest revision as of 23:59, 17 October 2014

iGEM 2014 Microfluidics Track

Bronze Medal


Silver Medal

In addition to these, our team achieved the following goals that qualify us for a silver medal:


Gold Medal

In addition to the Bronze and Silver Medal requirements, our team achieved the following goals, that qualify us for a gold medal:

  • Utilizing our novel fluidic system, we have characterized the function of an existing Part. Any biological protocols performed utilizing our microfluidic system are documented. We compared biological protocols conducted on-chip against standard bench top techniques. Data collected is uploaded to the page of the part(s) used on the Registry of Standard Biological Parts via experience page/contribution system.
  • Utilizing the fluidic system, we have characterized the following new Parts:
  • Our team helped other registered iGEM teams from other institutions by characterizing a part and collaborated with other registered iGEM teams.
  • During the summer we addressed several ethical concerns related to our project, eg. bringing synthetic biology outside the lab, the possibility that a microbial sensor device that detects landmines can get into the wrong hands and safety issues. To answer all these questions, we had meetings with various stakeholders. All these aspects are well documented on our Policy&Practice page
  • .

iGEM Special Prizes

Our team has additional achievements that make it eligible for the following prizes:

  • Best Model: For the conductive curli module, we wanted to know if a conductive path between two electrodes of a chip filled with curli growing E. coli arise at a certain point in time. We also wanted to make quantitative predictions about the resistance between the two electrodes of our system in time. We used a stochastic modeling approach, and considered the system at the gene, cell and colony level. At the colony levvel, we employed percolation theory in order to predict if a conductive path between the two electrodes arise at a certain point in time and to predict at which time this happens. Our application of percolation theory to describe the formation of a conductive biological network represents a novel approach that has not been used in the literature before.
  • Best Policy&Practice: By interviewing and discussing with a broad range of stakeholders, we have been able to determine the best application for our landmine detection module. Besides that, we have identified various issues concerning SynBio commercialization, such as legislature and public opinion, focused on the Netherlands, and proposed a strategy to guarantee a successful future for SynBio.
  • Best Measurement Approach: We measured the current our modified E. coli generated via a selfmade anaerobic bioreactor setup coupled to a potentiostat in order to be able to measure current created by modified E. coli. Subsequently, we miniaturized our potentiostat system, creating a microfluidics device (an improved version of the Dropsens).
  • Best Supporting Software: We wrote code for Labview in order to be able to perform the relevant measurements for our potentiostat setup. This code can be used by others to perform these measurements as well.


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