"
Team:UST Beijing
From 2014.igem.org
(Difference between revisions)
Liuyingxuan (Talk | contribs) |
Liuyingxuan (Talk | contribs) |
||
| (13 intermediate revisions not shown) | |||
| Line 253: | Line 253: | ||
<li><a href="https://2014.igem.org/Team:UST_Beijing/Parts">Parts</a></li> | <li><a href="https://2014.igem.org/Team:UST_Beijing/Parts">Parts</a></li> | ||
<li><a href="https://2014.igem.org/Team:UST_Beijing/Modeling">Modeling</a></li> | <li><a href="https://2014.igem.org/Team:UST_Beijing/Modeling">Modeling</a></li> | ||
| + | <li><a href="https://2014.igem.org/Team:UST_Beijing/Outreach">Outreach</a></li> | ||
<li class="dropdown"> | <li class="dropdown"> | ||
| Line 277: | Line 278: | ||
<div class="carousel-caption"> | <div class="carousel-caption"> | ||
<h1>Learn from ancestors.</h1> | <h1>Learn from ancestors.</h1> | ||
| - | <p class="lead"> | + | <p class="lead">An undesirable mutation deprived one of our beloved magics - providing vitamin C for ourselves. Fortunately, we might be able to pick it up from our ancestors.</p> |
</div> | </div> | ||
</div> | </div> | ||
| Line 287: | Line 288: | ||
<div class="container"> | <div class="container"> | ||
<h2 class="bs-docs-featurette-title">Through evolution, we lost something.</h2> | <h2 class="bs-docs-featurette-title">Through evolution, we lost something.</h2> | ||
| - | <p class="lead">Looking back at the footsteps of evolution, we human being exploit our limits and potentials to adapt mercurial environment and harsh conditions. | + | <p class="lead">Looking back at the footsteps of evolution, we human being exploit our limits and potentials to adapt mercurial environment and harsh conditions. We have, however, lost some magical potentials in this process. The capability to generate vitamin C for ourselves is one of the lost magics. </p> |
<hr class="half-rule"> | <hr class="half-rule"> | ||
| Line 295: | Line 296: | ||
<img id="monkey" src="https://static.igem.org/mediawiki/2014/2/26/Monkey1.png" alt="" class="img-responsive"> | <img id="monkey" src="https://static.igem.org/mediawiki/2014/2/26/Monkey1.png" alt="" class="img-responsive"> | ||
<h3>Ancestors</h3> | <h3>Ancestors</h3> | ||
| - | <p>Mutations in L-gulono-gama-lactone oxidase(GLO) gene in many vertebrate species caused the lack of expression of GLO, which leads to a loss of capability to produce vitamin C. As a result of this mutation, many species including human being developed their dependence on food source vitamin C.</p> | + | <p align="left">Mutations in L-gulono-gama-lactone oxidase(GLO) gene in many vertebrate species caused the lack of expression of GLO, which leads to a loss of capability to produce vitamin C. As a result of this mutation, many species including human being developed their dependence on food source vitamin C.</p> |
</div> | </div> | ||
<div class="col-sm-4"> | <div class="col-sm-4"> | ||
<img id="human1" src="https://static.igem.org/mediawiki/2014/0/03/Monkey4.png" alt="" class="img-responsive"> | <img id="human1" src="https://static.igem.org/mediawiki/2014/0/03/Monkey4.png" alt="" class="img-responsive"> | ||
<h3>We Human</h3> | <h3>We Human</h3> | ||
| - | <p> | + | <p align="left">Vitamin C has been playing a pivotal role in scavenging free radical and collagen synthesis. People with long-time insufficient ingestion of vitamin C, sailors for instance, could suffer from scurvy disease. To make matters worse, accumulation of free radical could be an important factor of aging.</p> |
</div> | </div> | ||
<div class="col-sm-4"> | <div class="col-sm-4"> | ||
<img id="human2" src="https://static.igem.org/mediawiki/2014/3/3d/Monkey3.png" alt="" class="img-responsive"> | <img id="human2" src="https://static.igem.org/mediawiki/2014/3/3d/Monkey3.png" alt="" class="img-responsive"> | ||
<h3>Solutions?</h3> | <h3>Solutions?</h3> | ||
| - | <p>The truth is, we lost the | + | <p align="left">The truth is, we lost the ability to provide an indispensable vitamin to ourselves. And here's what we are working around: can we find out a way to reactivate GLO gene and express functional GLO, hence pick up our long-lost magic? We've conducted cell-level experiments and evaluated their possible effects.</p> |
</div> | </div> | ||
</div> | </div> | ||
| Line 316: | Line 317: | ||
<div class="container"> | <div class="container"> | ||
<h2 class="bs-docs-featurette-title">The answer is fusion.</h2> | <h2 class="bs-docs-featurette-title">The answer is fusion.</h2> | ||
| - | <p class="lead">Lemur catta，also called Lemur, is a kind of monkey and one of the two species of anthropoids with full and functional GLO gene. Lemur could be a good source of GLO gene if intend to regain our capability of producing | + | <p class="lead">Lemur catta，also called Lemur, is a kind of monkey and one of the two species of anthropoids with full and functional GLO gene. Lemur could be a good source of GLO gene if intend to regain our capability of producing vitamin C, just like our ancestors. However, there's still a long way to go.</p> |
<div class="row"> | <div class="row"> | ||
| Line 325: | Line 326: | ||
<div class="col-sm-4"> | <div class="col-sm-4"> | ||
| - | <img src="https://static.igem.org/mediawiki/2014/ | + | <img src="https://static.igem.org/mediawiki/2014/2/23/Genefused.png" alt="" class="img-responsive"> |
</div> | </div> | ||
| Line 355: | Line 356: | ||
<p><br></p> | <p><br></p> | ||
| - | <p><font size=2.5>Built with love | + | <p><font size=2.5>Built with love<br>By the iGEM14 team of <a href="http://www.ustb.edu.cn/">University of Science and Technology Beijing</a></font></p> |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
</font> | </font> | ||
</ul> | </ul> | ||
Latest revision as of 18:40, 16 October 2014
Learn from ancestors.
An undesirable mutation deprived one of our beloved magics - providing vitamin C for ourselves. Fortunately, we might be able to pick it up from our ancestors.
Through evolution, we lost something.
Looking back at the footsteps of evolution, we human being exploit our limits and potentials to adapt mercurial environment and harsh conditions. We have, however, lost some magical potentials in this process. The capability to generate vitamin C for ourselves is one of the lost magics.
Ancestors
Mutations in L-gulono-gama-lactone oxidase(GLO) gene in many vertebrate species caused the lack of expression of GLO, which leads to a loss of capability to produce vitamin C. As a result of this mutation, many species including human being developed their dependence on food source vitamin C.
We Human
Vitamin C has been playing a pivotal role in scavenging free radical and collagen synthesis. People with long-time insufficient ingestion of vitamin C, sailors for instance, could suffer from scurvy disease. To make matters worse, accumulation of free radical could be an important factor of aging.
Solutions?
The truth is, we lost the ability to provide an indispensable vitamin to ourselves. And here's what we are working around: can we find out a way to reactivate GLO gene and express functional GLO, hence pick up our long-lost magic? We've conducted cell-level experiments and evaluated their possible effects.
The answer is fusion.
Lemur catta，also called Lemur, is a kind of monkey and one of the two species of anthropoids with full and functional GLO gene. Lemur could be a good source of GLO gene if intend to regain our capability of producing vitamin C, just like our ancestors. However, there's still a long way to go.
